Effects of Black ginger (Kaempferia parviflora) on the testicular function in streptozotocin-induced diabetic male rats
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Published:
Dec 30, 2016
Keywords:
Diabetes mellitus Testes Testosterone Kaempferia parviflora
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Abstract
The present study aimed to investigate the efficacy of Black ginger (Kaempferia parviflora; KP) on testicular function in streptozotocin (STZ)-induced diabetes rats (DM). Six-week-old male Wistar rats were used in this experiment. All rats were randomly divided into six group; group 1: Normal group, group 2: DM (control), group 3: DM rats received gibencamide 5 mg/kg, group 4-6: DM rats received KP 140, 280 and 420 mg/kg, respectively. DM was induced by intraperitoneal injection of STZ (60 mg/kg). All animals were treated for 6 weeks. Blood glucose, epididymal sperm parameter, testicular microstructure and testosterone level were evaluated. The result showed that KP treatment has no effect on blood glucose in DM rats. KP treatment showed significantly increased sperm density, serum testosterone and ameliorates testicular structure in DM rats (p<0.05). The present study indicates that the aphrodisiac properties of KP could improve of sperm density, testosterone level and testicular function in STZ-induced diabetes rats.
Article Details
How to Cite
Fungfuang, W., Lert-Amornpat, T., & Maketon, C. (2016). Effects of Black ginger (Kaempferia parviflora) on the testicular function in streptozotocin-induced diabetic male rats. Veterinary Integrative Sciences, 14(3), 95–107. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/146103
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Review Article
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References
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Bal, R., Türk, G., Tuzcu, M., Yilmaz, O., Ozercan, I., Kuloglu, T., Gür, S., Nedzuetsky, V.S., Tykhomyrov, A.A., Andrievsky, G.V., Baydas, G., Naziroglu, M. 2011. Protective effects of nanostructures of hydrated C60 fullerene on reproductive function in streptozotocin-diabetic male rats. Toxicology. 282: 69-81.
Bayram, S., Kizilay, G., Topcu-Tarladacalisir, Y. 2016. Evaluation of the Fas/FasL signaling pathway in diabetic rats testis. Biotech. Histochem. 91: 204211.
Celik, O., Kutlu, O., Tekcan, M., Celik-Ozenci, C., Koksal, I.T. 2013. Role of TNF-related apoptosis inducing ligand (TRAIL) in the pathogenesis of varicocele-induced testicular dysfunction. Asian J. Androl. 15: 269-274.
Chaturapanich, G., Chaiyakul, S., Verawatnapakul, V., Pholpramool, C. 2008. Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats. Reproduction. 136: 515-522.
De, A., Singh, M.F., Singh, V., Ram, V., Bisht, S. 2016. Treatment effect of L-Norvaline on the sexual performance of male rats with streptozotocin induced diabetes. Eur. J. Pharmacol. 771: 247254.
Heeba, G.H. and Hamza, A.A. 2015. Rosuvastatin ameliorats diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats. Life Sci. 141: 13-19.
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Horigome, S., Maeda, M., Ho, H.J., Shirakawa, H., Komai, M. 2016. Effect of extract and its polymethoxyflavonoid components on testosterone production in mouse testis-derived tumour cells. Journal of Functional Food. 26: 529-538.
Jangir, R.N., Jain, G.C. 2014. Diabetes mellitus induced impairment of male reproductive function: a review. Curr. Diabetes. Rev. 10: 147-157. Jansakul, C., Tachanaparuksa, K., Mulvany, M.J., Sukpondma, Y. 2012. Relaxant mechanisms of 3,5,7,3’,4’-pentamethoxyflavone on isolated human cavernosum. Eur. J. Pharmacol. 691: 235-244.
Jitjaingam, A., Kakaew, A., Saenphet, K., Saenphet, S., Aritajat, S. 2005. Effects of Kaempferia parviflora Wall. Ex. Baker on reproductive organs hematology and kidney function of male rats. Proceeding of the 31st Congress on Science and Technology of Thailand, Suranaree University of Technology, Nakhon Ratchasima, Thailand. Mekjaruskul, C., Sripanidkulchai, B. 2015. Pharmacokinetic interaction between Kaempferia parviflora extract and sildenafil in rats. J. Nat. Med. 69: 224-231.
Mulholland, J., Mallidis, C., Agbaje, I., McClure, N. 2011. Male diabetes mellitus and assisted reproduction treatment outcome. Reprod. Biomed. Online. 22: 215-219.
Murata, K., Hayashi, H., Matsumura, S., Matsuda, H. 2013. Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome. Pharmacognosy Res. 5: 309-314.
Nasrolahi, O., Khaneshi, F., Rahmani, F., Razi, M. 2013. Honey and metformin ameliorated diabetesinduced damages in testes of rat; correlation with hormonal changes. Iran J. Reprod. Med. 11: 1013-1020.
Navarro-Casado, L., Juncos-Tobarra, M.A., Cháfer-Rudilla, M., Íñguez De Onzoño, L., Blázquez-Cabrera, J.A., Miralles-García, J.M. 2010. Effects of experimental diabetes and STZ on male fertility capacity. Study in rats. J. Androl. 31: 584-592.
R Core Team. 2016. R: A language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria. [Online] Available : https://www.R-project.org.
Roehrs, M., Figueiredo, C.G., Zanchi, M.M., Bochi, G.V., Moresco, R.N., Quatrin, A., Somacal, S., Conte, L., Emanuelli, T. 2014. Bixin and norbixin have opposite effects on glycemia, lipidemia and oxidative stress in streptozotocin-induced diabetic rats. Int. J. Endocrinol. 2014: 839095.
Scarano, W.R., Messias, A.G., Oliva, S.U., Klinefelter, G.R., Kempinas, G. 2006. Sexual behaviour, sperm quantity and quality after short-term streptozotocin-induced hyperglycemia in rats. Int. J. Andro. 29: 482-488.
Shimada, T., Horikawa, T., Ikeya, Y., Matsuo, H., Kinoshita, K., Taguchi, T., Ichinose, K., Takahashi, K., Aburada, M. 2011. Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polytmethoxy flavonoid on metabolic diseases. Fitoterapia. 82: 1272-1278.
Shrilatha, B, 2007. Early oxidative stress in testis and epididymal sperm in strptozotocin-induced diabetic mice:its progression and genotoxic consequences. Reprod. Toxicol. 23: 578-587.
Somphol, N., Hongkhumtod, P., Vongpralab, T., Sanchaisuriya, P., Chinchiyanont, W., Prasuk, Y. 2003. Effect of Boesenbergia pandurata (black rhizome) supplementation on semen characteristics in male rabbits. Proceedings of the Annual Academic Meeting of the Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand: 46-54.
Sudwan, P., Saenphet, K., Saenphet, S., Suwansirikul, S. 2006. Effect of Kaempfera parviflora Wall. Ex. Baker on sexual activity of male rats and its toxicity. Southeast Asian J. Trop Med Public Health. 37: 210-215.
Sutthanut, K., Sripanidkulchai, B., Yenjai, C., Jay, M. 2007. Simultaneous identification and quantification of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography. J. Chromatogr. A. 1143: 227-233.
Temkitthawon, P., Hinds, T.R., Beavo, J.A., Viyoch, J., Suwanborirux, K., Pongamornkul, W., Sawasdee, P., Ingkaninan, K. 2011. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. J. Ethnopharmacol. 1373: 1437-1441.
Trisomboon, H., Tohei, A., Malaivijitnond, S., Watanabe, G., Taya, K., 2008. Oral administration of Kaempferia parviflora did not disturb male reproduction in rats. J. Reprod. Dev. 54: 375380. Tsounapi, P., Saito, M., Dimitriadis, F., Koukos, S., Shimizu, S., Satoh, K., Takenaka, A., Sofikitis, N. 2012. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Mol. Cell. Biochem. 369: 195-204. Wankeu-Nya, M., Watcho, P., Nguelefack, T., CarroJuarez, M., Tapondjou, L., Kamanyi, A. 2014. Effects of Dracaena arborea (Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats. Asian Pac. J. Trop. Med. 7: 609-619.
Wattanathorn, J., Muchimapura, S., Thon-Un, T., Saenghong, N., Thukum-Mee, W., Sripanidkulchai, B. 2012. Positive modulation effect of 8-week consumption of on healthrelated physical fitness and oxidative status in healthy elderly volunteers. Evid. Base. Complement. Alternat. Med. 2012: 732816.
Xu, Y., Lei, H., Guan, R., Gao, Z., Li, H., Wang, L., Hui, Y., Zhou, F., Xin, Z. 2014. Prophylactic protective effects and its potential mechanisms of IcarisideII on streptozotocin induced spermatogenic dysfunction. Int. J. Mol. Sci. 15: 16100-16113.
Youn, K., Lee, J., Ho, C., Jun, M. 2016. Discovery of polymehtoxyflavone from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors. Journal of Functional Foods. 20: 567-574.
Akase, T., Shimada, T., Terabayashi, S., Ikeya, Y., Sanada, H., Aburada, M. 2011. Antiobesity effects of Kaempferia parviflora in spontaneously obese type II diabetes mice. J. Nat. Med. 65: 73-80.
Atalay, U.B., Ilhan, F., Gulyuz, F., Karasu, A., Tas, A., Sendag. S., Wehrend, A. 2012. The effects of sildenafil citrate and vitamins A, C and E on testicular damage in alloxan-diabetic rats. J. Anim. Vet. Adv. 11: 56-63.
Bal, R., Türk, G., Tuzcu, M., Yilmaz, O., Ozercan, I., Kuloglu, T., Gür, S., Nedzuetsky, V.S., Tykhomyrov, A.A., Andrievsky, G.V., Baydas, G., Naziroglu, M. 2011. Protective effects of nanostructures of hydrated C60 fullerene on reproductive function in streptozotocin-diabetic male rats. Toxicology. 282: 69-81.
Bayram, S., Kizilay, G., Topcu-Tarladacalisir, Y. 2016. Evaluation of the Fas/FasL signaling pathway in diabetic rats testis. Biotech. Histochem. 91: 204211.
Celik, O., Kutlu, O., Tekcan, M., Celik-Ozenci, C., Koksal, I.T. 2013. Role of TNF-related apoptosis inducing ligand (TRAIL) in the pathogenesis of varicocele-induced testicular dysfunction. Asian J. Androl. 15: 269-274.
Chaturapanich, G., Chaiyakul, S., Verawatnapakul, V., Pholpramool, C. 2008. Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats. Reproduction. 136: 515-522.
De, A., Singh, M.F., Singh, V., Ram, V., Bisht, S. 2016. Treatment effect of L-Norvaline on the sexual performance of male rats with streptozotocin induced diabetes. Eur. J. Pharmacol. 771: 247254.
Heeba, G.H. and Hamza, A.A. 2015. Rosuvastatin ameliorats diabetes-induced reproductive damage via suppression of oxidative stress, inflammatory and apoptotic pathways in male rats. Life Sci. 141: 13-19.
Horigome, S., Yoshida, I., Ito, S., Inobana, S., Fushimi, K., Nagai, T., Yamaguchi, A., Fujita, K., Satoyama, T., Kasuda, S., Suzuki, S., Watai, M., Hirose, N., Mitsue, T., Shirakawa, H., Komai, M. 2015. Inhibitory effects of Kaempferia parviflora extract on monocyte adhesion and cellular reactive oxygen species production in human umbilical vein endothelial cells. Eur. J. Nutr. (Epub ahead of print): 10.1007/s00394-015-1141-5.
Horigome, S., Maeda, M., Ho, H.J., Shirakawa, H., Komai, M. 2016. Effect of extract and its polymethoxyflavonoid components on testosterone production in mouse testis-derived tumour cells. Journal of Functional Food. 26: 529-538.
Jangir, R.N., Jain, G.C. 2014. Diabetes mellitus induced impairment of male reproductive function: a review. Curr. Diabetes. Rev. 10: 147-157. Jansakul, C., Tachanaparuksa, K., Mulvany, M.J., Sukpondma, Y. 2012. Relaxant mechanisms of 3,5,7,3’,4’-pentamethoxyflavone on isolated human cavernosum. Eur. J. Pharmacol. 691: 235-244.
Jitjaingam, A., Kakaew, A., Saenphet, K., Saenphet, S., Aritajat, S. 2005. Effects of Kaempferia parviflora Wall. Ex. Baker on reproductive organs hematology and kidney function of male rats. Proceeding of the 31st Congress on Science and Technology of Thailand, Suranaree University of Technology, Nakhon Ratchasima, Thailand. Mekjaruskul, C., Sripanidkulchai, B. 2015. Pharmacokinetic interaction between Kaempferia parviflora extract and sildenafil in rats. J. Nat. Med. 69: 224-231.
Mulholland, J., Mallidis, C., Agbaje, I., McClure, N. 2011. Male diabetes mellitus and assisted reproduction treatment outcome. Reprod. Biomed. Online. 22: 215-219.
Murata, K., Hayashi, H., Matsumura, S., Matsuda, H. 2013. Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome. Pharmacognosy Res. 5: 309-314.
Nasrolahi, O., Khaneshi, F., Rahmani, F., Razi, M. 2013. Honey and metformin ameliorated diabetesinduced damages in testes of rat; correlation with hormonal changes. Iran J. Reprod. Med. 11: 1013-1020.
Navarro-Casado, L., Juncos-Tobarra, M.A., Cháfer-Rudilla, M., Íñguez De Onzoño, L., Blázquez-Cabrera, J.A., Miralles-García, J.M. 2010. Effects of experimental diabetes and STZ on male fertility capacity. Study in rats. J. Androl. 31: 584-592.
R Core Team. 2016. R: A language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria. [Online] Available : https://www.R-project.org.
Roehrs, M., Figueiredo, C.G., Zanchi, M.M., Bochi, G.V., Moresco, R.N., Quatrin, A., Somacal, S., Conte, L., Emanuelli, T. 2014. Bixin and norbixin have opposite effects on glycemia, lipidemia and oxidative stress in streptozotocin-induced diabetic rats. Int. J. Endocrinol. 2014: 839095.
Scarano, W.R., Messias, A.G., Oliva, S.U., Klinefelter, G.R., Kempinas, G. 2006. Sexual behaviour, sperm quantity and quality after short-term streptozotocin-induced hyperglycemia in rats. Int. J. Andro. 29: 482-488.
Shimada, T., Horikawa, T., Ikeya, Y., Matsuo, H., Kinoshita, K., Taguchi, T., Ichinose, K., Takahashi, K., Aburada, M. 2011. Preventive effect of Kaempferia parviflora ethyl acetate extract and its major components polytmethoxy flavonoid on metabolic diseases. Fitoterapia. 82: 1272-1278.
Shrilatha, B, 2007. Early oxidative stress in testis and epididymal sperm in strptozotocin-induced diabetic mice:its progression and genotoxic consequences. Reprod. Toxicol. 23: 578-587.
Somphol, N., Hongkhumtod, P., Vongpralab, T., Sanchaisuriya, P., Chinchiyanont, W., Prasuk, Y. 2003. Effect of Boesenbergia pandurata (black rhizome) supplementation on semen characteristics in male rabbits. Proceedings of the Annual Academic Meeting of the Faculty of Agriculture, Khon Kaen University, Khon Kaen, Thailand: 46-54.
Sudwan, P., Saenphet, K., Saenphet, S., Suwansirikul, S. 2006. Effect of Kaempfera parviflora Wall. Ex. Baker on sexual activity of male rats and its toxicity. Southeast Asian J. Trop Med Public Health. 37: 210-215.
Sutthanut, K., Sripanidkulchai, B., Yenjai, C., Jay, M. 2007. Simultaneous identification and quantification of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography. J. Chromatogr. A. 1143: 227-233.
Temkitthawon, P., Hinds, T.R., Beavo, J.A., Viyoch, J., Suwanborirux, K., Pongamornkul, W., Sawasdee, P., Ingkaninan, K. 2011. Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. J. Ethnopharmacol. 1373: 1437-1441.
Trisomboon, H., Tohei, A., Malaivijitnond, S., Watanabe, G., Taya, K., 2008. Oral administration of Kaempferia parviflora did not disturb male reproduction in rats. J. Reprod. Dev. 54: 375380. Tsounapi, P., Saito, M., Dimitriadis, F., Koukos, S., Shimizu, S., Satoh, K., Takenaka, A., Sofikitis, N. 2012. Antioxidant treatment with edaravone or taurine ameliorates diabetes-induced testicular dysfunction in the rat. Mol. Cell. Biochem. 369: 195-204. Wankeu-Nya, M., Watcho, P., Nguelefack, T., CarroJuarez, M., Tapondjou, L., Kamanyi, A. 2014. Effects of Dracaena arborea (Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats. Asian Pac. J. Trop. Med. 7: 609-619.
Wattanathorn, J., Muchimapura, S., Thon-Un, T., Saenghong, N., Thukum-Mee, W., Sripanidkulchai, B. 2012. Positive modulation effect of 8-week consumption of on healthrelated physical fitness and oxidative status in healthy elderly volunteers. Evid. Base. Complement. Alternat. Med. 2012: 732816.
Xu, Y., Lei, H., Guan, R., Gao, Z., Li, H., Wang, L., Hui, Y., Zhou, F., Xin, Z. 2014. Prophylactic protective effects and its potential mechanisms of IcarisideII on streptozotocin induced spermatogenic dysfunction. Int. J. Mol. Sci. 15: 16100-16113.
Youn, K., Lee, J., Ho, C., Jun, M. 2016. Discovery of polymehtoxyflavone from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors. Journal of Functional Foods. 20: 567-574.