MicroRNAs as a potential biomarker in bovine mastitis
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Published:
Apr 29, 2016
Keywords:
MicroRNAs Biomarker Mastitis Cow
Main Article Content
Abstract
MicroRNAs (miRNAs) are small, non-coding RNAs which have 19-25 nucleotides in length and can be found in a wide range of organisms, from plants to animals. The functions of miRNAs are to posttranscriptional control of gene expression via either protein translational repression or promote mRNA degradation. In cows, the extensive studies revealed, in part, that miRNAs play a pivotal role in regulating the expressions of protein-coding genes involving in pro-inflammation and inflammation stages during mastitis. In this review, we summarize recent literatures on the information and novel miRNAs found in cow genome. Furthermore, we also point a potential application of miRNAs as a biomarker for mastitis intervention and diagnostic tool in cows.
Article Details
How to Cite
Srikok, S., & Chuammitri, P. (2016). MicroRNAs as a potential biomarker in bovine mastitis. Veterinary Integrative Sciences, 14(1), 1–12. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/146135
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Review Article
Publishing an article with open access in Veterinary Integrative Sciences leaves the copyright with the author. The article is published under the Creative Commons Attribution License 4.0 (CC-BY 4.0), which allows users to read, copy, distribute and make derivative works from the material, as long as the author of the original work is cited.
References
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Chen, X., Liang, H., Zhang, J., Zen, K., Zhang, C.-Y., 2012. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 22, 125-132.
Cortez, M., Calin, G., 2009. MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin. Biol. Ther. 9, 703-711.
Coutinho, L.L., Matukumalli, L.K., Sonstegard, T.S., Van Tassell, C.P., Gasbarre, L.C., Capuco, A.V., Smith, T.P., 2007. Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues. Physiol. Genomics 29, 35-43.
de Candia, P., Torri, A., Pagani, M., Abrignani, S., 2014. Serum microRNAs as biomarkers of human lymphocyte activation in health and disease. Front. Immunol. 5:43. doi: 10.3389/fimmu.2014.00043.
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Goren, Y., Kushnir, M., Zafrir, B., Tabak, S., Lewis, B.S., Amir, O., 2012. Serum levels of microRNAs in patients with heart failure. Eur. J. Heart Fail. 14, 147-154.
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Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., Cao, X., 2009. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150-2158.
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Kosaka, N., Iguchi, H., Ochiya, T., 2010. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101, 2087-2092.
Krol, J., Loedige, I., Filipowicz, W., 2010. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597.
Lawless, N., Foroushani, A.B.K., McCabe, M.S., O’Farrelly, C., Lynn, D.J., 2013. Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection. PLoS ONE 8, e57543.
Lawless, N., Reinhardt, T.A., Bryan, K., Baker, M., Pesch, B., Zimmerman, D., Zuelke, K., Sonstegard, T., O’Farrelly, C., Lippolis, J.D., 2014. MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. G3: Genes Genomes Genetics 4, 957-971.
Leigh, J., Finch, J., Field, T., Real, N., Winter, A., Walton, A., Hodgkinson, S., 1999. Vaccination with the plasminogen activator from Streptococcus uberis induces an inhibitory response and protects against experimental infection in the dairy cow. Vaccine 17, 851-857.
Li, Z., Liu, H., Jin, X., Lo, L., Liu, J., 2012. Expression profiles of microRNAs from lactating and non lactating bovine mammary glands and identification of miRNA related to lactation. BMC Genomics 13, 731.
Liu, C.-G., Calin, G.A., Meloon, B., Gamliel, N., Sevignani, C., Ferracin, M., Dumitru, C.D., Shimizu, M., Zupo, S., Dono, M., 2004. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc. Natl. Acad. Sci. U.S.A. 101, 9740-9744.
Melnik, B.C., John, S.M., Schmitz, G., 2014. Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy. J. Transl. Med. 12, 43.
Mitchell, P.S., Parkin, R.K., Kroh, E.M., Fritz, B.R., Wyman, S.K., Pogosova-Agadjanyan, E.L., Peterson, A., Noteboom, J., O'Briant, K.C., Allen, A., 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U.S.A. 105, 10513-10518.
Naeem, A., Zhong, K., Moisá, S., Drackley, J., Moyes, K., Loor, J., 2012. Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis. J. Dairy Sci. 95, 6397-6408.
O'Connell, R.M., Rao, D.S., Baltimore, D., 2012. microRNA regulation of inflammatory responses. Annu. Rev. Immunol. 30, 295-312.
Oliver, S., Mitchell, B., 1984. Prevalence of mastitis pathogens in herds participating in a mastitis control program. J. Dairy Sci. 67, 2436-2440.
Pasquinelli, A.E., 2012. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 13, 271282.
Reinhardt, T.A., Lippolis, J.D., Nonnecke, B.J., Sacco, R.E., 2012. Bovine milk exosome proteome. J. Proteomics 75, 1486-1492.
Shabalina, S.A., Koonin, E.V., 2008. Origins and evolution of eukaryotic RNA interference. Trends Ecol. Evol. 23, 578-587.
Silveri, L., Tilly, G., Vilotte, J.-L., Le Provost, F., 2006. MicroRNA involvement in mammary gland development and breast cancer. Reprod. Nutr. Dev. 46, 549-556.
Siomi, H., Siomi, M.C., 2010. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 38, 323-332.
Smith, K.L., Todhunter, D., Schoenberger, P., 1985. Environmental pathogens and intramammary infection during the dry period 1, 2. J. Dairy Sci. 68, 402-417.
Sun, J., Aswath, K., Schroeder, S.G., Lippolis, J.D., Reinhardt, T.A., Sonstegard, T.S., 2015. MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics 16, 806.
Vegh, P., Foroushani, A.B., Magee, D.A., McCabe, M.S., Browne, J.A., Nalpas, N.C., Conlon, K.M., Gordon, S.V., Bradley, D.G., MacHugh, D.E., 2013. Profiling microRNA expression in bovine alveolar macrophages using RNA-seq. Vet. Immunol. Immunopathol. 155, 238-244.
Wang, J.-f., Yu, M.-l., Yu, G., Bian, J.-j., Deng, X.-m., Wan, X.-j., Zhu, K.-m., 2010. Serum miR-146a and miR-223 as potential new biomarkers for sepsis. Biochem.Biophys.Res.Comm. 394, 184-188.
Wang, M., Moisá, S., Khan, M., Wang, J., Bu, D., Loor, J., 2012. MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation. J. Dairy Sci. 95, 6529-6535.
Weber, J.A., Baxter, D.H., Zhang, S., Huang, D.Y., Huang, K.H., Lee, M.J., Galas, D.J., Wang, K., 2010. The microRNA spectrum in 12 body fluids. Clin. Chem. 56, 1733-1741.
Winter, J., Jung, S., Keller, S., Gregory, R.I., Diederichs, S., 2009. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 11, 228-234.
Yamada, T., Inoshima, Y., Matsuda, T., Ishiguro, N., 2012. Comparison of methods for isolating exosomes from bovine milk. J. Vet. Med. Sci. 74, 15231525.
Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C.B., Liu, S., 2010. A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS ONE 5, e13735.
Zhou, Q., Li, M., Wang, X., Li, Q., Wang, T., Zhu, Q., Zhou, X., Wang, X., Gao, X., Li, X., 2012. Immunerelated microRNAs are abundant in breast milk exosomes. Int. J. Biol. Sci. 8, 118.
Bartel, D.P., 2009. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233.
Bradley, A.J., 2002. Bovine mastitis: an evolving disease. Vet. J. 164, 116-128.
Ceppi, M., Pereira, P.M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M.A., Pierre, P., 2009. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 106, 2735-2740.
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., 2008. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997-1006.
Chen, X., Gao, C., Li, H., Huang, L., Sun, Q., Dong, Y., Tian, C., Gao, S., Dong, H., Guan, D., 2010. Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 20, 1128-1137.
Chen, X., Liang, H., Zhang, J., Zen, K., Zhang, C.-Y., 2012. Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 22, 125-132.
Cortez, M., Calin, G., 2009. MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases. Expert Opin. Biol. Ther. 9, 703-711.
Coutinho, L.L., Matukumalli, L.K., Sonstegard, T.S., Van Tassell, C.P., Gasbarre, L.C., Capuco, A.V., Smith, T.P., 2007. Discovery and profiling of bovine microRNAs from immune-related and embryonic tissues. Physiol. Genomics 29, 35-43.
de Candia, P., Torri, A., Pagani, M., Abrignani, S., 2014. Serum microRNAs as biomarkers of human lymphocyte activation in health and disease. Front. Immunol. 5:43. doi: 10.3389/fimmu.2014.00043.
Dilda, F., Gioia, G., Pisani, L., Restelli, L., Lecchi, C., Albonico, F., Bronzo, V., Mortarino, M., Ceciliani, F., 2012. Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes. Vet. J. 192, 514-516.
Fatima, A., Morris, D.G., 2013. MicroRNAs in domestic livestock. Physiol. Genomics 45, 685-696.
Filipowicz, W., Bhattacharyya, S.N., Sonenberg, N., 2008. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat. Rev. Genet. 9, 102-114.
Flicek, P., Amode, M.R., Barrell, D., Beal, K., Billis, K., Brent, S., Carvalho-Silva, D., Clapham, P., Coates, G., Fitzgerald, S., 2014. Ensembl 2014. Nucleic Acids Res., 42, D749-755..
Glazov, E.A., Kongsuwan, K., Assavalapsakul, W., Horwood, P.F., Mitter, N., Mahony, T.J., 2009. Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection. PLoS ONE 4, e6349.
Goren, Y., Kushnir, M., Zafrir, B., Tabak, S., Lewis, B.S., Amir, O., 2012. Serum levels of microRNAs in patients with heart failure. Eur. J. Heart Fail. 14, 147-154.
Griffiths-Jones, S., Grocock, R.J., Van Dongen, S., Bateman, A., Enright, A.J., 2006. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34, D140D144.
Gu, Z., Eleswarapu, S., Jiang, H., 2007. Identification and characterization of microRNAs from the bovine adipose tissue and mammary gland. FEBS Lett. 581, 981-988.
Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., Cao, X., 2009. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183, 2150-2158.
Howard, K.M., Jati Kusuma, R., Baier, S.R., Friemel, T., Markham, L., Vanamala, J., Zempleni, J., 2015. Loss of miRNAs during processing and storage of cow’s (Bos taurus) milk. J. Agric. Food Chem. 63, 588-592.
Jin, W., Ibeagha-Awemu, E.M., Liang, G., Beaudoin, F., Zhao, X., Guan, l.L., 2014. Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. BMC Genomics 15, 181.
Koga, Y., Yasunaga, M., Moriya, Y., Akasu, T., Fujita, S., Yamamoto, S., Matsumura, Y., 2011. Exosome can prevent RNase from degrading microRNA in feces. J. Gastrointest. Oncol. 2, 215.
Kosaka, N., Iguchi, H., Ochiya, T., 2010. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101, 2087-2092.
Krol, J., Loedige, I., Filipowicz, W., 2010. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597.
Lawless, N., Foroushani, A.B.K., McCabe, M.S., O’Farrelly, C., Lynn, D.J., 2013. Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection. PLoS ONE 8, e57543.
Lawless, N., Reinhardt, T.A., Bryan, K., Baker, M., Pesch, B., Zimmerman, D., Zuelke, K., Sonstegard, T., O’Farrelly, C., Lippolis, J.D., 2014. MicroRNA regulation of bovine monocyte inflammatory and metabolic networks in an in vivo infection model. G3: Genes Genomes Genetics 4, 957-971.
Leigh, J., Finch, J., Field, T., Real, N., Winter, A., Walton, A., Hodgkinson, S., 1999. Vaccination with the plasminogen activator from Streptococcus uberis induces an inhibitory response and protects against experimental infection in the dairy cow. Vaccine 17, 851-857.
Li, Z., Liu, H., Jin, X., Lo, L., Liu, J., 2012. Expression profiles of microRNAs from lactating and non lactating bovine mammary glands and identification of miRNA related to lactation. BMC Genomics 13, 731.
Liu, C.-G., Calin, G.A., Meloon, B., Gamliel, N., Sevignani, C., Ferracin, M., Dumitru, C.D., Shimizu, M., Zupo, S., Dono, M., 2004. An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc. Natl. Acad. Sci. U.S.A. 101, 9740-9744.
Melnik, B.C., John, S.M., Schmitz, G., 2014. Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy. J. Transl. Med. 12, 43.
Mitchell, P.S., Parkin, R.K., Kroh, E.M., Fritz, B.R., Wyman, S.K., Pogosova-Agadjanyan, E.L., Peterson, A., Noteboom, J., O'Briant, K.C., Allen, A., 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U.S.A. 105, 10513-10518.
Naeem, A., Zhong, K., Moisá, S., Drackley, J., Moyes, K., Loor, J., 2012. Bioinformatics analysis of microRNA and putative target genes in bovine mammary tissue infected with Streptococcus uberis. J. Dairy Sci. 95, 6397-6408.
O'Connell, R.M., Rao, D.S., Baltimore, D., 2012. microRNA regulation of inflammatory responses. Annu. Rev. Immunol. 30, 295-312.
Oliver, S., Mitchell, B., 1984. Prevalence of mastitis pathogens in herds participating in a mastitis control program. J. Dairy Sci. 67, 2436-2440.
Pasquinelli, A.E., 2012. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 13, 271282.
Reinhardt, T.A., Lippolis, J.D., Nonnecke, B.J., Sacco, R.E., 2012. Bovine milk exosome proteome. J. Proteomics 75, 1486-1492.
Shabalina, S.A., Koonin, E.V., 2008. Origins and evolution of eukaryotic RNA interference. Trends Ecol. Evol. 23, 578-587.
Silveri, L., Tilly, G., Vilotte, J.-L., Le Provost, F., 2006. MicroRNA involvement in mammary gland development and breast cancer. Reprod. Nutr. Dev. 46, 549-556.
Siomi, H., Siomi, M.C., 2010. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 38, 323-332.
Smith, K.L., Todhunter, D., Schoenberger, P., 1985. Environmental pathogens and intramammary infection during the dry period 1, 2. J. Dairy Sci. 68, 402-417.
Sun, J., Aswath, K., Schroeder, S.G., Lippolis, J.D., Reinhardt, T.A., Sonstegard, T.S., 2015. MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection. BMC Genomics 16, 806.
Vegh, P., Foroushani, A.B., Magee, D.A., McCabe, M.S., Browne, J.A., Nalpas, N.C., Conlon, K.M., Gordon, S.V., Bradley, D.G., MacHugh, D.E., 2013. Profiling microRNA expression in bovine alveolar macrophages using RNA-seq. Vet. Immunol. Immunopathol. 155, 238-244.
Wang, J.-f., Yu, M.-l., Yu, G., Bian, J.-j., Deng, X.-m., Wan, X.-j., Zhu, K.-m., 2010. Serum miR-146a and miR-223 as potential new biomarkers for sepsis. Biochem.Biophys.Res.Comm. 394, 184-188.
Wang, M., Moisá, S., Khan, M., Wang, J., Bu, D., Loor, J., 2012. MicroRNA expression patterns in the bovine mammary gland are affected by stage of lactation. J. Dairy Sci. 95, 6529-6535.
Weber, J.A., Baxter, D.H., Zhang, S., Huang, D.Y., Huang, K.H., Lee, M.J., Galas, D.J., Wang, K., 2010. The microRNA spectrum in 12 body fluids. Clin. Chem. 56, 1733-1741.
Winter, J., Jung, S., Keller, S., Gregory, R.I., Diederichs, S., 2009. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 11, 228-234.
Yamada, T., Inoshima, Y., Matsuda, T., Ishiguro, N., 2012. Comparison of methods for isolating exosomes from bovine milk. J. Vet. Med. Sci. 74, 15231525.
Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C.B., Liu, S., 2010. A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS ONE 5, e13735.
Zhou, Q., Li, M., Wang, X., Li, Q., Wang, T., Zhu, Q., Zhou, X., Wang, X., Gao, X., Li, X., 2012. Immunerelated microRNAs are abundant in breast milk exosomes. Int. J. Biol. Sci. 8, 118.