Lipid abnormalities in atopic dermatitis
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Published:
Dec 30, 2014
Keywords:
Lipid Atopic dermatitis dog Ceramide
Main Article Content
Abstract
The outermost layer of epiderm is as known Stratum corneum establishes skin barrier function. Stratum corneum is composed of lining up of many fl attened corniocytes that adhere to each other by extracellular lipid lamellae (ELL). There are three major lipids components of ELL that are ceramides (CERs), chloresterol, and free fatty acid (FFA). Structural and function impairment of CERs represent in human and animal suffering with atopic dermatitis, cause of increasing transepidermal water loss (TEWL), increasing percutaneous invasive of environmental allergen, and easier to induce skin hypersensitivity reaction. Thus, skin barrier repair, especially additional topical CERs, is interesting in veterinarian now a day and may benefi t to be an alternative treatment in canine atopic dermatitis.
Article Details
How to Cite
Phongroop, K. (2014). Lipid abnormalities in atopic dermatitis. Veterinary Integrative Sciences, 12(3), 179–189. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/146497
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Review Article
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References
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Akdis, C. A., Akdis, M., Bieber, T., Bindslev-Jensen, C., Boguniewicz, M., Eigenmann, P., . . . Immunology. (2006). Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology /American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Journal of Allergy and Clinical Immunology, 118(1), 152-169.
Baker, B. S. (2006). The role of microorganisms in atopic dermatitis. Clinical & Experimental Immunology, 144(1), 1-9.
Baumer, W., Rossbach, K., Mischke, R., Reines, I., Langbein-Detsch, I., Luth, A., & Kleuser, B. (2011). Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. Journal of Investigative Dermatology, 131(1), 266-268.
Behne, M., Uchida, Y., Seki, T., de Montellano, P. O., Elias, P. M., & Holleran, W. M. (2000). Omega hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. Journal of Investigative Dermatology, 114(1), 185-192.
Bouwstra, J. A., & Ponec, M. (2006). The skin barrier in healthy and diseased state. Biochimica et Biophysica Acta, 1758(12), 2080-2095.
Coderch, L., Lopez, O., de la Maza, A., & Parra, J. L. (2003). Ceramides and skin function. Journal of the America Academy of Dermatology, 4(2), 107-129.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato Venereologica, 78(1), 27-30.
Doering, T., Proia, R. L., & Sandhoff, K. (1999). Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase defi cient type 2 Gaucher mice. FEBS Letters, 447(2-3), 167-170.
Elias, P. M. (1983). Epidermal lipids, barrier function, and desquamation. Journal of Investigative Dermatology, 80 Suppl, 44s-49s.
Elias, P. M. (2014). Lipid abnormalities and lipid-based repair strategies in atopic dermatitis. Biochimica et Biophysica Acta, 1841(3), 323-330.
Halliwell, R. (2006). Revised nomenclature for veterinary allergy. Veterinary Immunology and Immunopathology, 114(3-4), 207-208.
Herzinger, T., Kleuser, B., Schafer-Korting, M., & Korting, H. C. (2007). Sphingosine-1-phosphate signaling and the skin. Journal of the America Academy of Dermatology, 8(6), 329-336.
Hillier, A., & Griffi n, C. E. (2001). The ACVD taxk force on canine atopic dermatitis (I): incidence and prevalence. Veterinary Immunology and Immunopathology, 81, 147-151.
Holleran, W. M., Ginns, E. I., Menon, G. K., Grundmann, J. U., Fartasch, M., McKinney, C. E., . . . Sidransky, E. (1994). Consequences of beta-glucocerebrosidase defi ciency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. Journal of Clinical Investigation, 93(4), 1756-1764.
Holleran, W. M., Man, M. Q., Gao, W. N., Menon, G. K., Elias, P. M., & Feingold, K. R. (1991). Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. Journal of Clinical Investigation, 88(4), 1338-1345.
doi: 10.1172/JCI115439 Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991). Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? Journal of Investigative Dermatology, 96(4), 523-526.
Inman, A. O., Olivry, T., Dunston, S. M., Monteiro-Riviere, N. A., & Gatto, H. (2001). Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs. Veterinary Pathology, 38(6), 720-723.
Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., . . . Hatamochi, A. (2010). Changes in the ceramide profi le of atopic dermatitis patients. Journal of Investigative Dermatology, 130(10), 2511-2514.
Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., . . . Bouwstra, J. A. (2011). Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema. Journal of Investigative Dermatology, 131(10), 2136-2138.
Johansson, O., Liang, Y., Heilborn, J. D., & Marcusson, J. A. (1998). Langerhans cells in prurigo nodularis investigated by HLA-DR and S-100 immunofl uorescence double staining. Journal of Dermatological Science, 17(1), 24-32.
Kabashima, K. (2012). Pathomechanism of atopic dermatitis in the perspective of T cell subsets and skin barrier functions–“Which comes fi rst, the chicken or the egg?”. Dermatologica Sinica, 30(4), 142-146.
Kabashima, K. (2013). New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity. Journal of Dermatological Science, 70(1), 3-11.
Macheleidt, O., Kaiser, H. W., & Sandhoff, K. (2002). Defi ciency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. Journal of Investigative Dermatology, 119(1), 166-173.
Marsella, R. (2013). Fixing the skin barrier: past, present and future - man and dog compared. Veterinary Dermatology, 24(1), 73-+.
Marsella, R., Olivry, T., & Carlotti, D. N. (2011). Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Veterinary Dermatology, 22(3), 239-248.
Marsella, R., Samuelson, D., & Doerr, K. (2010). Transmission electron microscopy studies in an experimental model of canine atopic dermatitis. Veterinary Dermatology, 21(1), 81-88.
Masukawa, Y., Narita, H., Sato, H., Naoe, A., Kondo, N., Sugai, Y., . . . Kitahara, T. (2009). Comprehensive quantifi cation of ceramide species in human stratum corneum. Journal of Lipid Research, 50(8), 1708-1719.
Mizutani, Y., Mitsutake, S., Tsuji, K., Kihara, A., & Igarashi, Y. (2009). Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie, 91(6), 784-790.
Nishifuji, K. (2014). Skin barrier and its role in the pathophysiology of atopic dermatitis. In C. Noli, A. Foster & W. Rosenkrantz (Eds.), Veterinary Allergy (pp. 42-50).
UK: John Wiley & Sons, Ltd. Olivry, T. (2011). Is the skin barrier abnormal in dogs with atopic dermatitis? Veterinary Immunology and Immunopathology, 144(1-2), 11-16.
Olivry, T., DeBoer, D. J., Favrot, C., Jackson, H. A., Mueller, R. S., Nuttall, T., & Prelaud, P. (2010). Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Veterinary Dermatology, 21(3), 233-248.
Olivry, T., Wofford, J., Paps, J. S., & Dunston, S. M. (2011). Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs. Veterinary Dermatology, 22(2), 188-196.
Pellicoro, C., Marsella, R., & Ahrens, K. (2013). Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis. Veterinary Medicine International, 2013, 239186.
Piekutowska, A., Pin, D., Reme, C. A., Gatto, H., & Haftek, M. (2008). Effects of a topically applied preparation of epidermal lipids on the stratum corneum barrier of atopic dogs. Journal of Comparative Pathology, 138(4), 197-203.
Popa, I., Thuy, L. H., Colsch, B., Pin, D., Gatto, H., Haftek, M., & Portoukalian, J. (2010). Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. Archives of Dermatological Research, 302(9), 639-644.
Reiter, L. V., Torres, S. M., & Wertz, P. W. (2009). Characterization and quantifi cation of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Veterinary Dermatology, 20(4), 260-266.
Rothe, M. J., & Grant-Kels, J. M. (1996). Atopic dermatitis: an update. Journal of the American Academy of Dermatology, 35, 1-13.
Scott, D. W., Miller, W. H., & Griffi n, C. E. (2001). Small Animal Dermatology. Philadelphia: W.B. Saunders. Shimada, K., Yoon, J. S., Yoshihara, T., Iwasaki, T., & Nishifuji, K. (2009). Increased transepidermal water loss and decreased ceramide content in lesional and non-lesional skin of dogs with atopic dermatitis. Veterinary Dermatology, 20(5-6), 541-546.
Shimada, K., Yoshihara, T., Yamamoto, M., Konno, K., Momoi, Y., Nishifuji, K., & Iwasaki, T. (2008). Transepidermal water loss (TEWL) refl ects skin barrier function of dog. Journal of Veterinary Medical Science, 70(8), 841-843.
Tokura, Y. (2010). Extrinsic and intrinsic types of atopic dermatitis. Journal of Dermatological Science, 58(1), 1-7. Wood, S. H., Clements, D. N., Ollier, W. E., Nuttall, T., McEwan, N. A., & Carter, S. D. (2009). Gene expression in canine atopic dermatitis and correlation with clinical severity scores. Journal of Dermatological Science, 55(1), 27-33.
Yoon, J. S., Nishifuji, K., Sasaki, A., Ide, K., Ishikawa, J., Yoshihara, T., & Iwasaki, T. (2011). Alteration of stratum corneum ceramide profi les in spontaneous canine model of atopic dermatitis. Experimental Dermatology, 20(9), 732-736.
Akdis, C. A., Akdis, M., Bieber, T., Bindslev-Jensen, C., Boguniewicz, M., Eigenmann, P., . . . Immunology. (2006). Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology /American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. Journal of Allergy and Clinical Immunology, 118(1), 152-169.
Baker, B. S. (2006). The role of microorganisms in atopic dermatitis. Clinical & Experimental Immunology, 144(1), 1-9.
Baumer, W., Rossbach, K., Mischke, R., Reines, I., Langbein-Detsch, I., Luth, A., & Kleuser, B. (2011). Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis. Journal of Investigative Dermatology, 131(1), 266-268.
Behne, M., Uchida, Y., Seki, T., de Montellano, P. O., Elias, P. M., & Holleran, W. M. (2000). Omega hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. Journal of Investigative Dermatology, 114(1), 185-192.
Bouwstra, J. A., & Ponec, M. (2006). The skin barrier in healthy and diseased state. Biochimica et Biophysica Acta, 1758(12), 2080-2095.
Coderch, L., Lopez, O., de la Maza, A., & Parra, J. L. (2003). Ceramides and skin function. Journal of the America Academy of Dermatology, 4(2), 107-129.
Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato Venereologica, 78(1), 27-30.
Doering, T., Proia, R. L., & Sandhoff, K. (1999). Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase defi cient type 2 Gaucher mice. FEBS Letters, 447(2-3), 167-170.
Elias, P. M. (1983). Epidermal lipids, barrier function, and desquamation. Journal of Investigative Dermatology, 80 Suppl, 44s-49s.
Elias, P. M. (2014). Lipid abnormalities and lipid-based repair strategies in atopic dermatitis. Biochimica et Biophysica Acta, 1841(3), 323-330.
Halliwell, R. (2006). Revised nomenclature for veterinary allergy. Veterinary Immunology and Immunopathology, 114(3-4), 207-208.
Herzinger, T., Kleuser, B., Schafer-Korting, M., & Korting, H. C. (2007). Sphingosine-1-phosphate signaling and the skin. Journal of the America Academy of Dermatology, 8(6), 329-336.
Hillier, A., & Griffi n, C. E. (2001). The ACVD taxk force on canine atopic dermatitis (I): incidence and prevalence. Veterinary Immunology and Immunopathology, 81, 147-151.
Holleran, W. M., Ginns, E. I., Menon, G. K., Grundmann, J. U., Fartasch, M., McKinney, C. E., . . . Sidransky, E. (1994). Consequences of beta-glucocerebrosidase defi ciency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. Journal of Clinical Investigation, 93(4), 1756-1764.
Holleran, W. M., Man, M. Q., Gao, W. N., Menon, G. K., Elias, P. M., & Feingold, K. R. (1991). Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. Journal of Clinical Investigation, 88(4), 1338-1345.
doi: 10.1172/JCI115439 Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991). Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? Journal of Investigative Dermatology, 96(4), 523-526.
Inman, A. O., Olivry, T., Dunston, S. M., Monteiro-Riviere, N. A., & Gatto, H. (2001). Electron microscopic observations of stratum corneum intercellular lipids in normal and atopic dogs. Veterinary Pathology, 38(6), 720-723.
Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., . . . Hatamochi, A. (2010). Changes in the ceramide profi le of atopic dermatitis patients. Journal of Investigative Dermatology, 130(10), 2511-2514.
Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., . . . Bouwstra, J. A. (2011). Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema. Journal of Investigative Dermatology, 131(10), 2136-2138.
Johansson, O., Liang, Y., Heilborn, J. D., & Marcusson, J. A. (1998). Langerhans cells in prurigo nodularis investigated by HLA-DR and S-100 immunofl uorescence double staining. Journal of Dermatological Science, 17(1), 24-32.
Kabashima, K. (2012). Pathomechanism of atopic dermatitis in the perspective of T cell subsets and skin barrier functions–“Which comes fi rst, the chicken or the egg?”. Dermatologica Sinica, 30(4), 142-146.
Kabashima, K. (2013). New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity. Journal of Dermatological Science, 70(1), 3-11.
Macheleidt, O., Kaiser, H. W., & Sandhoff, K. (2002). Defi ciency of epidermal protein-bound omega-hydroxyceramides in atopic dermatitis. Journal of Investigative Dermatology, 119(1), 166-173.
Marsella, R. (2013). Fixing the skin barrier: past, present and future - man and dog compared. Veterinary Dermatology, 24(1), 73-+.
Marsella, R., Olivry, T., & Carlotti, D. N. (2011). Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Veterinary Dermatology, 22(3), 239-248.
Marsella, R., Samuelson, D., & Doerr, K. (2010). Transmission electron microscopy studies in an experimental model of canine atopic dermatitis. Veterinary Dermatology, 21(1), 81-88.
Masukawa, Y., Narita, H., Sato, H., Naoe, A., Kondo, N., Sugai, Y., . . . Kitahara, T. (2009). Comprehensive quantifi cation of ceramide species in human stratum corneum. Journal of Lipid Research, 50(8), 1708-1719.
Mizutani, Y., Mitsutake, S., Tsuji, K., Kihara, A., & Igarashi, Y. (2009). Ceramide biosynthesis in keratinocyte and its role in skin function. Biochimie, 91(6), 784-790.
Nishifuji, K. (2014). Skin barrier and its role in the pathophysiology of atopic dermatitis. In C. Noli, A. Foster & W. Rosenkrantz (Eds.), Veterinary Allergy (pp. 42-50).
UK: John Wiley & Sons, Ltd. Olivry, T. (2011). Is the skin barrier abnormal in dogs with atopic dermatitis? Veterinary Immunology and Immunopathology, 144(1-2), 11-16.
Olivry, T., DeBoer, D. J., Favrot, C., Jackson, H. A., Mueller, R. S., Nuttall, T., & Prelaud, P. (2010). Treatment of canine atopic dermatitis: 2010 clinical practice guidelines from the International Task Force on Canine Atopic Dermatitis. Veterinary Dermatology, 21(3), 233-248.
Olivry, T., Wofford, J., Paps, J. S., & Dunston, S. M. (2011). Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs. Veterinary Dermatology, 22(2), 188-196.
Pellicoro, C., Marsella, R., & Ahrens, K. (2013). Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis. Veterinary Medicine International, 2013, 239186.
Piekutowska, A., Pin, D., Reme, C. A., Gatto, H., & Haftek, M. (2008). Effects of a topically applied preparation of epidermal lipids on the stratum corneum barrier of atopic dogs. Journal of Comparative Pathology, 138(4), 197-203.
Popa, I., Thuy, L. H., Colsch, B., Pin, D., Gatto, H., Haftek, M., & Portoukalian, J. (2010). Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs. Archives of Dermatological Research, 302(9), 639-644.
Reiter, L. V., Torres, S. M., & Wertz, P. W. (2009). Characterization and quantifi cation of ceramides in the nonlesional skin of canine patients with atopic dermatitis compared with controls. Veterinary Dermatology, 20(4), 260-266.
Rothe, M. J., & Grant-Kels, J. M. (1996). Atopic dermatitis: an update. Journal of the American Academy of Dermatology, 35, 1-13.
Scott, D. W., Miller, W. H., & Griffi n, C. E. (2001). Small Animal Dermatology. Philadelphia: W.B. Saunders. Shimada, K., Yoon, J. S., Yoshihara, T., Iwasaki, T., & Nishifuji, K. (2009). Increased transepidermal water loss and decreased ceramide content in lesional and non-lesional skin of dogs with atopic dermatitis. Veterinary Dermatology, 20(5-6), 541-546.
Shimada, K., Yoshihara, T., Yamamoto, M., Konno, K., Momoi, Y., Nishifuji, K., & Iwasaki, T. (2008). Transepidermal water loss (TEWL) refl ects skin barrier function of dog. Journal of Veterinary Medical Science, 70(8), 841-843.
Tokura, Y. (2010). Extrinsic and intrinsic types of atopic dermatitis. Journal of Dermatological Science, 58(1), 1-7. Wood, S. H., Clements, D. N., Ollier, W. E., Nuttall, T., McEwan, N. A., & Carter, S. D. (2009). Gene expression in canine atopic dermatitis and correlation with clinical severity scores. Journal of Dermatological Science, 55(1), 27-33.
Yoon, J. S., Nishifuji, K., Sasaki, A., Ide, K., Ishikawa, J., Yoshihara, T., & Iwasaki, T. (2011). Alteration of stratum corneum ceramide profi les in spontaneous canine model of atopic dermatitis. Experimental Dermatology, 20(9), 732-736.