The treatment of feline idiopathic pulmonary arterial hypertension with beraprost sodium
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Abstract
An 11 months old, Thai domestic short hair male cat was brought to Kasetsart University Veterinary Teaching Hospital, Bang Khaen in June 2007. The cat showed signs of exercise intolerance, syncope, and sometimes had opened-mouth breathing. The owner noticed these symptoms since he was 4 months old and had been treated previously by local veterinarian since then, but the symptoms remained unimproved. The cat had opened-mouth breathing and sometimes abdominal breathing after struggling with the restraint procedures. Hematological results were normal. The thoracic radiograph showed normal heart and lung patterns. ECG showed normal sinus rhythm with no evidence of heart axis deviation. The enlargement of right atrium and ventricle were revealed by echocardiogram which related to pulmonary arterial hypertension. The cat was treated with oral beraprost sodium every 48 hours. The clinical sign and clinical complain on exercise intolerance were improved after 2 weeks of treatment. Two months later, the echocardiography showed that the size of left ventricle return to normal because it had no abnormal pressure from the right ventricle. The treatment of cat with idiopathic pulmonary arterial hypertension using beraprost sodium showed an appropriate response.
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References
Campbell, F. E. (2007). Cardiac effects of pulmonary disease. Veterinary Clinics of North America : Small Animal Practice, 37(5), 949-962,
vii. doi: S0195-5616(07)00059-9 [pii]10.1016/j. cvsm.2007.05.006 Committee of Thai Guideline for Diagnosis and Treatment of Pulmonary Hypertension 2013. (2013) Committee of Thai Guideline for Diagnosis and Treatment of Pulmonary Hypertension 2013, Bangkok: Colour Harmony Co., Ltd.
Galie, N., Humbert, M., Vachiery, J. L., Vizza, C. D., Kneussl, M., Manes, A., et al. (2002). Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial. Journal of the American College of Cardiology, 39(9), 1496-1502.
doi: S0735109702017862 [pii] Latimer, K. S., Mahaffey, E. A., & Preasse, K. W. (2003). Duncan and Prasse’s Veterinary laboratory medicine: Clinical Pathology (4th ed.). Iowa: Iowa State University Press.
MacDonald, K. A., & Johnson, L. R. (2005). Pulmonary Hypertension and pulmonary thromboembolism. In S. J. Ettinger & E. C. Feldman (Eds.), Textbook of Veterinary Internal Medicine (6th ed., pp. 1284-1288).
St. Louis: Elsevier. Sastravaha, A., Thengchaisri, N., Theerapan, W.& Niyom, S. (2006). Case Report: Diagnosis of congenital pulmonic stenosis in puppy. Congress Proceedings : The 12th Veterinary Practitioner Association of Thailand Congress, 199-205. (in Thai)
Simonneau, G., Robbins, I. M., Beghetti, M., Channick, R. N., Delcroix, M., Denton, C. P., et al. (2009). Updated clinical classifi cation of pulmonary hypertension. Journal of the American College of Cardiology, 54(1 Suppl), S43-54.
doi: S0735-1097(09)01216-9 [pii]10.1016/j.jacc. 2009.04.012 Tilley, L. P. (1992). Essentials of canine and Feline Electrocardiography: interpretation and treatment (Vol. 3rd).
Philadephia: Lea & Febiger. Umetsu, T., Murata, T., Tanaka, Y., Osada, E., & Nishio, S. (1987). Antithrombotic effect of TRK-100, a novel, stable PGI2 analogue. The Japanese Journal of Phamacology, 43(1), 81-90.
Ware, W. A. (2007). Cardiovascular Disease in Small Animal Medicine. London: Manson Publishing Ltd.