Amitraz toxicity in a horse

Main Article Content

Kanittha Phetudomsinsuk
Natchaya Soontornsook
Nuttapon Phanusaweekul
Watcharapol Pathomsakulwong

Abstract

A 3-year-old Thoroughbred mare was presented to the Equine Clinic, Kasetsart University Veterinary Teaching Hospital following the pour-on amitraz treatment for two days. The horse showed typical clinical signs of colic including depression, inappetite, pawing, sweating, non-defecation, anuria, and ataxia. The clinical examinations revealed heart rate 38 beats/minute, respiratory rate 17 breaths/minute, small and fi rm fecal balls covered with white membrane, and impaction at pelvic fl exure of the large colon. The horse survived after intensive symptomatic treatment with intravenous fl uids therapy, intermittent gastric lavages, intravenous non steroid anti-infl ammatory drugs, yohimbine, and enteral fl uids administration via nasogastric tube. The horse was completely recovered within 72 hours after the initiation of yohimbine administration.

Article Details

How to Cite
Phetudomsinsuk, K., Soontornsook, N., Phanusaweekul, N., & Pathomsakulwong, W. (2014). Amitraz toxicity in a horse. Veterinary Integrative Sciences, 12(3), 233–238. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/146533
Section
Case Report

References

Andrade, S. F., Sakate, M., Laposy, C. B., Valente, S. F., 1Bettanim, V. M., Rodrigues, L. T., & Marcicano, J. (2007).Effects of experimental amitraz intoxication in cats.ArquivoBrasileiro de MedicinaVeterinária e Zootecnia, 59(5), 1236–1244.

Andrade, S. F., Sakate, M, &Crocci, J. (2005). Effects of yohimbine and atipamezole on plasmatic glucose concentration and blood gas analysis in dogs intoxicated with triatox. ArsVeterinária (Brazil), 21(4).121-128.

Atabek, M. E., Aydin, K., &Erkul, I. (2002).Different clinical features of amitraz poisoning in children. Human & Experimental Toxicology, 21(1), 13–16.

Auer, D. E., Seawright, A. A., Pollitt, C. C., & Williams, G. (1984). Illness in horses following spraying with amitraz. Australian Veterinary Journal, 61(8), 257–259.

Aydin, K., Kurtoğlu, S., Poyrazoğlu, M. H., Uzüm, K., Ustünbaş, H. B., &Hallaç, I. K. (1997). Amitraz poisoning in children: clinical and laboratory fi ndings of eight cases. Human & Experimental Toxicology, 16(11), 680–682.

Bonsall, J. L., & Turnbull, G. J. (1983).Extrapolation from safety data to management of poisoning with reference to amitraz (a formamidine pesticide) and xylene. Human Toxicology, 2(4), 587–592.

Cowan, L. A., & Campbell, K. (1988). Generalized demodicosis in a cat responsive to amitraz. Journal of the American Veterinary Medical Association, 192(10), 1442–1444.

Doganay, Z., Aygun, D., Altintop, L., Guven, H., &Bildik, F. (2002). Basic toxicological approach has been effective in two poisoned patients with amitraz ingestion: case reports. Human & Experimental Toxicology, 21(1), 55–57.

Garnier, R., Chataigner, D., &Djebbar, D. (1998).Six human cases of amitrazpoisoning.Human& Experimental Toxicology, 17(5), 294.

Gunaratnam, P., Wilkinson, G. T., &Seawright, A. A. (1983). A study of amitraz toxicity in cats. Australian Veterinary Journal, 60(9), 278–279.

Hsu, W.H. (1996). Antiparasitic Agents. In: AHRENS, F.A. (Ed). Farmacology.Baltimore: Willians& Wilkins, p.243-260.

Hsu, W. H., &McNeel, S. V. (1985).Amitraz-Induced Prolongation of Gastrointestinal Transit and Bradycardia in Dogs and their Antagonism by Yohimbine: Preliminary Study. Drug and Chemical Toxicology, 8(4), 239–253.

Hugnet, C., Buronrosse, F., Pineau, X., Cadoré, J. L., Lorgue, G., &Berny, P. J. (1996).Toxicity and kinetics of amitraz in dogs. American Journal of Veterinary Research, 57(10), 1506–1510.

Jorens, P. G., Zandijk, E., Belmans, L., Schepens, P. J., &Bossaert, L. L. (1997).An unusual poisoning with the unusual pesticide amitraz. Human & Experimental Toxicology, 16(10), 600–601.

Lavole P.J. &Hinchcliff K. (2002).Blackwlell’s Five-minute veterinary consonsult: Equine.Iowa : Blackwell Publishing. Miller, D. B., & O’Callaghan, J. P. (2002). Neuroendocrine aspects of the response to stress. Metabolism: Clinical and Experimental, 51(6 Suppl 1), 5–10. Noble, R.E. (2002): Diagnosis of stress. Metabolism. 51: 37-39.


Proudfoot, A.T. (2003). Poisoning with amitraz.Toxicological Reviews. 22(2):71-74.

Queiroz-Neto, A., Carregaro, A. B., Zamur, G., Harkins, J. D., Tobin, T., Mataqueiro, M. I., &Gonçalves, S. C. (2000).Effect of amitraz and xylazine on some physiological variables of horses. ArquivoBrasileiro de MedicinaVeterinária e Zootecnia, 52(1), 27–32.

Roberts, M. &Seawright, A. . (1979). Amitraz induced large intestinal impaction in the horse. Australian veterinary journal, 55(11), 553–4.

Scott, D.W., Miller W.H. and Griffi n G.E. (Eds).(1996). Dermatologia de pequenosanimais. Rio de Janeiro: Interlivros. p.1130. Smith, S.E. (1994). Treatment of mange in horses. The Veterinary record.134: 508-508,

Soli, N.E. &Braseth, T.A. (1992).Ectodex poisoning in a cat reversed with Antisedan. Norsk- Veterinaertidsskrift. 104: 25-26.

Yilmaz, H.L. &Yildizdas D.R. (2003). Amitraz poisoning, an emerging problem: epidemiology, clinical features, management, and preventive strategies. Archives of disease in childhood. 88: 130-134.

Zipes, D.P. (1992). Specifi c arrhythmias: diagnosis and treatment. In: BRAUNWALD, E. (Ed). Heartdisease: a textbook of cardiovascular medicine. Philadelphia: WB Saunders, p.667-725.