Lubricin: roles and applications in osteoarthritis
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Published:
Aug 29, 2014
Keywords:
boundary lubricant superfi cial zone coeffi cient of friction mechanical forces osteoarthritis
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Abstract
Osteoarthritis is joint disease caused by articular cartilage degeneration. This disease lead pain and suffering in daily life. Although completely cure of this disease is not determined, intra-articular injection of hyarulonan protein is an effi cient treatment for osteoarthritis. In this case, lubricin which is glycoproteins located at superfi cial zone of cartilage or cartilage surface that secreted by chondrocytes andsynoviocytes was unveiled. Boundary lubrication is the main function of this protein following with anti-cell adhesion under various mechanical forces when moving joints. In human, mutations or lacking of this gene have been reported to link with camptodactyly -arthropathy-coxavarapericarditis syndrome (CACP) that leads high risks of arthritis occurrence. Synovial hyperplasia and joint failure will be occurred also. This could be suggesting the important roles of lubricin in joint diseases with the application of articular injection of lubricin that exhibited effective restoration of joint in animal models. Therefore, lubricin could be the new interesting substance to be applied in osteoarthritis treatment. This review article is gathered, unveiled and discussed the important structure, functions of lubricin both in normal and arthritic joints and the approaches using lubricin as the new protein to cure osteoarthritis.
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Pradit, W., Buddhachat, K., Pitakarnnop, T., Boonsri, B., & Nganvongpanit, K. (2014). Lubricin: roles and applications in osteoarthritis. Veterinary Integrative Sciences, 12(2), 131–144. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/146566
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Review Article
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References
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Ballantine, G. C., & Stachowiak, G. W. (2002). The effects of lipid depletion on osteoarthritic wear. Wear, 253(3–4), 385-393.
Buschmann, M. D., Kim, Y. J., Wong, M., Frank, E., Hunziker, E. B., & Grodzinsky, A. J. (1999). Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fl uid fl ow. Archives of Biochemistry and Biophysics, 366(1), 1-7.
Chang, D. P., Abu-Lail, N. I., Coles, J. M., Guilak, F., Jay, G. D., & Zauscher, S. (2009). Friction Force Microscopy of Lubricin and Hyaluronic Acid between Hydrophobic and Hydrophilic Surfaces. Journal of Soft Matter, 5(18), 3438-3445.
Daniel, M. (2013). Boundary cartilage lubrication: review of current concepts. Wien Med Wochenschr. Darling, E. M., & Athanasiou, K. A. (2005). Growth factor impact on articular cartilage subpopulations. Cell and tissue research, 322(3), 463-473.
Das, R. H. J., Jahr, H., Verhaar, J. A. N., van der Linden, J. C., van Osch, G. J. V. M., & Weinans, H. (2008). In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthritis Cartilage, 16(3), 385-391.
Das, S., Banquy, X., Zappone, B., Greene, G. W., Jay, G. D., & Israelachvili, J. N. (2013). Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication. Biomacromolecules, 14(5), 1669-1677.
Drewniak, E. I., Jay, G. D., Fleming, B. C., Zhang, L., Warman, M. L., & Crisco, J. J. (2012). Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees. Arthritis & Rheumatism, 64(2), 465-473.
Elsaid, K. A., Fleming, B. C., Oksendahl, H. L., Machan, J. T., Fadale, P. D., Hulstyn, M. J., . . . Jay, G. D. (2008). Decreased lubricin concentrations and markers of joint infl ammation in the synovial fl uid of patients with anterior cruciate ligament injury. Arthritis & Rheumatism, 58(6), 1707-1715.
Elsaid, K. A., Jay, G. D., Warman, M. L., Rhee, D. K., & Chichester, C. O. (2005). Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fl uid following injury and infl ammatory arthritis. Arthritis & Rheumatism, 52(6), 1746-1755.
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Englert, C., McGowan, K. B., Klein, T. J., Giurea, A., Schumacher, B. L., & Sah, R. L. (2005). Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fl uid. Arthritis & Rheumatism, 52(4), 1091-1099.
Estrella, R. P., Whitelock, J. M., Packer, N. H.,& Karlsson, N. G. (2010). The glycosylation of human synovial lubricin: implications for its role in infl ammation. The Biochemical Journal,29(2), 359-367.
Flannery, C. R., Hughes, C. E., Schumacher, B. L., Tudor, D., Aydelotte, M. B., Kuettner, K. E., & Caterson, B. (1999). Articular cartilage superfi cial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochemical and Biophysical Research Communications, 254(3), 535 541.
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Grad, S., Lee, C. R., Wimmer, M. A., & Alini, M. (2006). Chondrocyte gene expression under applied surface motion. Journal of Biorheology, 43(3-4), 259-269.
Hodge, W. A., Carlson, K. L., Fijan, R. S., Burgess, R. G., Riley, P. O., Harris, W. H., & Mann, R. W. (1989). Contact pressures from an instrumented hip endoprosthesis. The Journal of Bone and Joint Surgery, 71(9), 1378-1386.
Ikegawa, S., Sano, M., Koshizuka, Y., & Nakamura, Y. (2000). Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenetics and cell genetics, 90(3-4), 291-297.
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Jay, G. D., & Cha, C. J. (1999). The effect of phos pholipase digestion upon the boundary lubricating ability of synovial fl uid. The Journal of Rheumatology, 26(11), 2454-2457.
Jay, G. D., Elsaid, K. A., Kelly, K. A., Anderson, S. C., Zhang, L., Teeple, E., . . . Fleming, B. C. (2012). Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis & Rheumatism, 64(4), 1162-1171.
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Jay, G. D., Tantravahi, U., Britt, D. E., Barrach, H. J., & Cha, C. J. (2001). Homology of lubricin and superfi cial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fi broblasts and articular chondrocytes localized to chromosome 1q25. Journal of orthopaedic research : offi cial publication of the Orthopaedic Research Society. 19(4), 677-687.
Jay, G. D., Torres, J. R., Rhee, D. K., Helminen, H. J., Hytinnen, M. M., Cha, C.-J., . . . Warman, M. L. (2007). Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis & Rheumatism, 56(11), 3662-3669.
Jay, G. D., Torres, J. R., Warman, M. L., Laderer, M. C., & Breuer, K. S. (2007). The role of lubricin in the mechanical behavior of synovial fl uid. Proceedings of the National Academy of Sciences U S A, 104(15), 6194-6199.
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Ballantine, G. C., & Stachowiak, G. W. (2002). The effects of lipid depletion on osteoarthritic wear. Wear, 253(3–4), 385-393.
Buschmann, M. D., Kim, Y. J., Wong, M., Frank, E., Hunziker, E. B., & Grodzinsky, A. J. (1999). Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fl uid fl ow. Archives of Biochemistry and Biophysics, 366(1), 1-7.
Chang, D. P., Abu-Lail, N. I., Coles, J. M., Guilak, F., Jay, G. D., & Zauscher, S. (2009). Friction Force Microscopy of Lubricin and Hyaluronic Acid between Hydrophobic and Hydrophilic Surfaces. Journal of Soft Matter, 5(18), 3438-3445.
Daniel, M. (2013). Boundary cartilage lubrication: review of current concepts. Wien Med Wochenschr. Darling, E. M., & Athanasiou, K. A. (2005). Growth factor impact on articular cartilage subpopulations. Cell and tissue research, 322(3), 463-473.
Das, R. H. J., Jahr, H., Verhaar, J. A. N., van der Linden, J. C., van Osch, G. J. V. M., & Weinans, H. (2008). In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthritis Cartilage, 16(3), 385-391.
Das, S., Banquy, X., Zappone, B., Greene, G. W., Jay, G. D., & Israelachvili, J. N. (2013). Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication. Biomacromolecules, 14(5), 1669-1677.
Drewniak, E. I., Jay, G. D., Fleming, B. C., Zhang, L., Warman, M. L., & Crisco, J. J. (2012). Cyclic loading increases friction and changes cartilage surface integrity in lubricin-mutant mouse knees. Arthritis & Rheumatism, 64(2), 465-473.
Elsaid, K. A., Fleming, B. C., Oksendahl, H. L., Machan, J. T., Fadale, P. D., Hulstyn, M. J., . . . Jay, G. D. (2008). Decreased lubricin concentrations and markers of joint infl ammation in the synovial fl uid of patients with anterior cruciate ligament injury. Arthritis & Rheumatism, 58(6), 1707-1715.
Elsaid, K. A., Jay, G. D., Warman, M. L., Rhee, D. K., & Chichester, C. O. (2005). Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fl uid following injury and infl ammatory arthritis. Arthritis & Rheumatism, 52(6), 1746-1755.
Elsaid, K. A., Zhang, L., Waller, K., Tofte, J., Teeple, E., Fleming, B. C., & Jay, G. D. (2012). The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin's effect in exercised joints following ACL transection. Osteoarthritis Cartilage, 20(8), 940-948.
Englert, C., McGowan, K. B., Klein, T. J., Giurea, A., Schumacher, B. L., & Sah, R. L. (2005). Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fl uid. Arthritis & Rheumatism, 52(4), 1091-1099.
Estrella, R. P., Whitelock, J. M., Packer, N. H.,& Karlsson, N. G. (2010). The glycosylation of human synovial lubricin: implications for its role in infl ammation. The Biochemical Journal,29(2), 359-367.
Flannery, C. R., Hughes, C. E., Schumacher, B. L., Tudor, D., Aydelotte, M. B., Kuettner, K. E., & Caterson, B. (1999). Articular cartilage superfi cial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochemical and Biophysical Research Communications, 254(3), 535 541.
Flannery, C. R., Zollner, R., Corcoran, C., Jones, A. R., Root, A., Rivera-Bermúdez, M. A., . . . Glasson, S. S. (2009). Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis & Rheumatism, 60(3), 840-847.
Grad, S., Lee, C. R., Gorna, K., Gogolewski, S., Wimmer, M. A., & Alini, M. (2005). Surface motion upregulates superfi cial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds. Journal of Tissue Engineering, 11(1-2), 249-256.
Grad, S., Lee, C. R., Wimmer, M. A., & Alini, M. (2006). Chondrocyte gene expression under applied surface motion. Journal of Biorheology, 43(3-4), 259-269.
Hodge, W. A., Carlson, K. L., Fijan, R. S., Burgess, R. G., Riley, P. O., Harris, W. H., & Mann, R. W. (1989). Contact pressures from an instrumented hip endoprosthesis. The Journal of Bone and Joint Surgery, 71(9), 1378-1386.
Ikegawa, S., Sano, M., Koshizuka, Y., & Nakamura, Y. (2000). Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenetics and cell genetics, 90(3-4), 291-297.
Jay, G. (2013). USA Patent No. 2013/0116186 A1 Jay, G. D. (1992). Characterization of a bovine sy novial fl uid lubricating factor. I. Chemical, surface activity and lubricating properties. Connective Tissue Research, 28(1-2), 71-88.
Jay, G. D., & Cha, C. J. (1999). The effect of phos pholipase digestion upon the boundary lubricating ability of synovial fl uid. The Journal of Rheumatology, 26(11), 2454-2457.
Jay, G. D., Elsaid, K. A., Kelly, K. A., Anderson, S. C., Zhang, L., Teeple, E., . . . Fleming, B. C. (2012). Prevention of cartilage degeneration and gait asymmetry by lubricin tribosupplementation in the rat following anterior cruciate ligament transection. Arthritis & Rheumatism, 64(4), 1162-1171.
Jay, G. D., Harris, D. A., & Cha, C. J. (2001). Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosac charides. Glycoconjugate Journal, 18(10), 807-815.
Jay, G. D., Tantravahi, U., Britt, D. E., Barrach, H. J., & Cha, C. J. (2001). Homology of lubricin and superfi cial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fi broblasts and articular chondrocytes localized to chromosome 1q25. Journal of orthopaedic research : offi cial publication of the Orthopaedic Research Society. 19(4), 677-687.
Jay, G. D., Torres, J. R., Rhee, D. K., Helminen, H. J., Hytinnen, M. M., Cha, C.-J., . . . Warman, M. L. (2007). Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis & Rheumatism, 56(11), 3662-3669.
Jay, G. D., Torres, J. R., Warman, M. L., Laderer, M. C., & Breuer, K. S. (2007). The role of lubricin in the mechanical behavior of synovial fl uid. Proceedings of the National Academy of Sciences U S A, 104(15), 6194-6199.
Jones, A. R. C., & Flannery, C. R. (2007). Bioregulation of lubricin expression by growth factors and cytokines. European cells & materials, 13, 40-45;
discussion 45. Jones, A. R. C., Gleghorn, J. P., Hughes, C. E., Fitz, L. J., Zollner, R., Wainwright, S. D., . . . Flannery, C. R. (2007). Binding and localization of recombinant lubricin to articular cartilage surfaces. Journal of Orthopaedic Research, 25(3), 283-292.
Jüsten, H. P., Grünewald, E., Totzke, G., Gouni Berthold, I., Sachinidis, A., Wessinghage, D., . . . Ko, Y. (2000). Differential gene expression in synovium of rheumatoid arthritis and osteoarthritis. Molecular Cell Biology Research Communications, 3(3), 165-172.
Khalafi , A., Schmid, T. M., Neu, C., & Reddi, A. H. (2007). Increased accumulation of super fi cial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors. Journal of Orthopaedic Research, 25(3), 293-303.
Klein, T. J., Schumacher, B. L., Schmidt, T. A., Li, K. W., Voegtline, M. S., Masuda, K., . . . Sah, R. L. (2003). Tissue engineering of stratifi ed articular cartilage from chondrocyte subpopulations. Osteoarthritis Cartilage, 11(8), 595-602.
Lee, S. Y., Nakagawa, T., & Reddi, A. H. (2008). Induction of chondrogenesis and expression of superfi cial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-beta1 and BMP-7. Biochemical and Biophysical Research Communications, 376(1), 148 153.
Li, Z., Yao, S., Alini, M., & Grad, S. (2007). Different response of articular chondrocyte subpopulations to surface motion. Osteoarthritis Cartilage, 15(9), 1034-1041.
Liu, Y. J., Lu, S. H., Xu, B., Yang, R. C., Ren, Q., Liu, B., . . . Han, Z. C. (2004). Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood, 103(12), 4449-4456.
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