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Degenerative mitral valve disease (DMVD) is a most common cardiac disease in dogs whichareusually found inold small breed dogs. Several factors can bethecauseof degeneration and serotonin is the one. In the present study, serotonin (5-hydroxytryptamine, 5HT) signaling can inducevalvular interstitialcell (VIC) differentiationand myxomatousvalve damage, but theetiology of this disease is unclear. The purpose of this study was to investigate the relationship between plasma serotonin and degenerative mitral valve disease in dogs. Dogs were divided into a normal group (n=7) and a treatment group (n=23). The treatment group was classified by the severity of the clinical signs in class I, II, III and IV group Blood samples were collected for an analysis of plasma serotonin level. The plasma serotonin level from varies group were compared by using the generalized linear mixed model. The results revealed that the plasma serotonin level in each group were different, the tendency of plasma serotonin level decreased when the severity of the disease was increased (P<0.05). The plasma serotonin level in class I group was higher than class II, III and IVgroups (P<0.05) and class I and II groupshad ahigher plasma serotoninlevel thanclass III and IV groups (P<0.05).
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