Prevalence and antibiotic resistance of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli in healthy dogs in Chiang Mai Jirapa
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Published:
Oct 25, 2018
Keywords:
Antibiotic resistance Escherichia coli Extended spectrum beta lactamase enzyme Fecal sample Healthy dogs Oral biofilm
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Abstract
The aim of the present study was to investigate the prevalence and the antibiotic resistance of ESBL-producing Escherichia coli in healthy dogs in Chiang Mai. Fecal and oral biofilm samples were collected from eighty nine healthy dogs presented at Veterinary Teaching Hospital Chiang Mai University for received vaccination or health checking. All samples were inoculated on MacConkey agar plates containing 1ug/ml of cefotaxime and E. coli confirmation was performed by using MALDI TOF MS. ESBL producing E. coli confirmation was performed by combination disc test and the positive isolates were subjected to antibiotic susceptibility testing using 12 antibiotic discs by disc diffusion methods. The prevalence of ESBL producing E. coli of fecal samples was 25.84 %. On the other hand ESBL producing E. coli from oral biofilm samples was not detected. All ESBL producing E. coli isolates were highly antibiotic drug resistant, especially ampicillin, cefazolin, cephalexin and clindamycin (100% resistant). Furthermore, they had multi-drug resistance pattern. It is concluded that fecal ESBL producing E. coli can be found in healthy dogs and leads to the high antibiotic resistant rates. This information may increase awareness of animal-to-human or animal-to-animal transmission.
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Thepmanee, J., Rodroo, J., Awaiwanont, N., Intanon, M., Na Lampang, K., Thitaram, N., & Thongkorn, K. (2018). Prevalence and antibiotic resistance of extended-spectrum beta-lactamase (ESBL) producing Escherichia coli in healthy dogs in Chiang Mai Jirapa. Veterinary Integrative Sciences, 16(3), 233–245. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/152432
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References
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CDC | Antibiotic Resistance Threats in the United States. (2013). Retrieved March 26, 2018, from https://www.cdc.gov/drugresistance/threat-report-2013/index.html
Chung, Y. S., Park, Y. K., Park, Y. H., & Park, K. T. (2017). Probable secondary transmission of antimicrobial-resistant Escherichia coli between people living with and without pets. The Journal of Veterinary Medical Science, 79(3), 486–491. https://doi.org/10.1292/jvms.16-0585
CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 24th ed. CLSI supplement M100. Wayne, PA: Clinical and Laboratory Standards Institute; 2014.
Costa, D., Poeta, P., Briñas, L., Sáenz, Y., Rodrigues, J., & Torres, C. (2004). Detection of CTX-M-1 and TEM-52 beta-lactamases in Escherichia coli strains from healthy pets in Portugal. The Journal of Antimicrobial Chemotherapy, 54(5), 960–961. https://doi.org/10.1093/jac/dkh444
Costa, D., Poeta, P., Sáenz, Y., Coelho, A. C., Matos, M., Vinué, L., … Torres, C. (2008). Prevalence of antimicrobial resistance and resistance genes in faecal Escherichia coli isolates recovered from healthy pets. Veterinary Microbiology, 127(1–2), 97–105. https://doi.org/10.1016/j.vetmic.2007.08.004
Damborg, P., Morsing, M. K., Petersen, T., Bortolaia, V., & Guardabassi, L. (2015). CTX-M-1 and CTX-M-15-producing Escherichia coli in dog faeces from public gardens. Acta Veterinaria Scandinavica, 57. https://doi.org/10.1186/s13028-015-0174-3
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Espinosa-Gongora, C., Qaswar Ali Shah, S., Jessen, L. R., Bortolaia, V., Langebaek, R., Bjornvad, C. R., & Guardabassi, L. (2015). Quantitative assessment of faecal shedding of beta-lactam-resistant Escherichia coli and enterococci in dogs. Veterinary Microbiology, 181(3–4), 298–302. https://doi.org/10.1016/j.vetmic.2015.10.004
Ewers, C., Grobbel, M., Stamm, I., Kopp, P. A., Diehl, I., Semmler, T., … Guenther, S. (2010). Emergence of human pandemic O25:H4-ST131 CTX-M-15 extended-spectrum-beta-lactamase-producing Escherichia coli among companion animals. The Journal of Antimicrobial Chemotherapy, 65(4), 651–660. https://doi.org/10.1093/jac/dkq004
Falagas, M. E., & Karageorgopoulos, D. E. (2009). Extended-spectrum beta-lactamase-producing organisms. The Journal of Hospital Infection, 73(4), 345–354. https://doi.org/10.1016/j.jhin.2009.02.021
Guardabassi, L., Schwarz, S., & Lloyd, D. H. (2004). Pet animals as reservoirs of antimicrobial-resistant bacteria. The Journal of Antimicrobial Chemotherapy, 54(2), 321–332. https://doi.org/10.1093/jac/dkh332
Hagman, R., & Kühn, I. (2002). Escherichia coli strains isolated from the uterus and urinary bladder of bitches suffering from pyometra: comparison by restriction enzyme digestion and pulsed-field gel electrophoresis. Veterinary Microbiology, 84(1–2), 143–153.
Hanhaboon, P., Kimprasit, T., Wajjwalku, W., & Amavisit, P. (2015). Extended Spectrum Beta-lactamase Producing Escherichia coli Isolated from Infected Canines. The Thai Journal of Veterinary Medicine, 45(2), 263–267.
Harada, K., Nakai, Y., & Kataoka, Y. (2012). Mechanisms of resistance to cephalosporin and emergence of O25b-ST131 clone harboring CTX-M-27 β-lactamase in extraintestinal pathogenic Escherichia coli from dogs and cats in Japan. Microbiology and Immunology, 56(7), 480–485. https://doi.org/10.1111/j.1348-0421.2012.00463.x
Huber, H., Zweifel, C., Wittenbrink, M. M., & Stephan, R. (2013). ESBL-producing uropathogenic Escherichia coli isolated from dogs and cats in Switzerland. Veterinary Microbiology, 162(2–4), 992–996. https://doi.org/10.1016/j.vetmic.2012.10.029
Lee, J. H., Bae, I. K., & Lee, S. H. (2012). New definitions of extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance. Medicinal Research Reviews, 32(1), 216–232. https://doi.org/10.1002/med.20210
Leite-Martins, L., Meireles, D., Beça, N., Bessa, L. J., de Matos, A. J. F., & Martins da Costa, P. (2015). Spread of multidrug-resistant Escherichia coli within domestic aggregates (humans, pets, and household environment). Journal of Veterinary Behavior: Clinical Applications and Research, 10(6), 549–555. https://doi.org/10.1016/j.jveb.2015.07.040
Ljungquist, O., Ljungquist, D., Myrenås, M., Rydén, C., Finn, M., & Bengtsson, B. (2016). Evidence of household transfer of ESBL-/pAmpC-producing Enterobacteriaceae between humans and dogs – a pilot study. Infection Ecology & Epidemiology, 6. https://doi.org/10.3402/iee.v6.31514
Macfarlane, G. T., & Macfarlane, S. (1997). Human colonic microbiota: ecology, physiology and metabolic potential of intestinal bacteria. Scandinavian Journal of Gastroenterology. Supplement, 222, 3–9. https://doi.org/10.1080/00365521.1997.11720708
Moreno, A., Bello, H., Guggiana, D., Domínguez, M., & González, G. (2008). Extended-spectrum beta-lactamases belonging to CTX-M group produced by Escherichia coli strains isolated from companion animals treated with enrofloxacin. Veterinary Microbiology, 129(1–2), 203–208. https://doi.org/10.1016/j.vetmic.2007.11.011
Münnich, A., & Lübke-Becker, A. (2004). Escherichia coli infections in newborn puppies--clinical and epidemiological investigations. Theriogenology, 62(3–4), 562–575. https://doi.org/10.1016/j.theriogenology.2003.11.012
Ogeer-Gyles, J., Mathews, K. A., Sears, W., Prescott, J. F., Weese, J. S., & Boerlin, P. (2006). Development of antimicrobial drug resistance in rectal Escherichia coli isolates from dogs hospitalized in an intensive care unit. Journal of the American Veterinary Medical Association, 229(5), 694–699. https://doi.org/10.2460/javma.229.5.694
Okubo, T., Sato, T., Yokota, S., Usui, M., & Tamura, Y. (2014). Comparison of broad-spectrum cephalosporin-resistant Escherichia coli isolated from dogs and humans in Hokkaido, Japan. Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy, 20(4), 243–249. https://doi.org/10.1016/j.jiac.2013.12.003
Oliveira, P. A. de, Moura, R. A., Rodrigues, G. V., Lopes, K. F. C., Zaniolo, M. M., Rubio, A. J., … Gonçalves, D. D. (2016). Detection of extended spectrum beta-lactamases and resistance in members of the Enterobacteriaceae family isolated from healthy sheep and dogs in Umuarama, Paraná, Brazil. Semina: Ciências Agrárias, Londrina, 37(2), 829–840. https://doi.org/10.5433/1679-0359.2016v37n2p829
Pitout, J. D. D., & Laupland, K. B. (2008). Extended-spectrum beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern. The Lancet. Infectious Diseases, 8(3), 159–166. https://doi.org/10.1016/S1473-3099(08)70041-0
Puño-Sarmiento, J., Medeiros, L., Chiconi, C., Martins, F., Pelayo, J., Rocha, S., … Nakazato, G. (2013). Detection of diarrheagenic Escherichia coli strains isolated from dogs and cats in Brazil. Veterinary Microbiology, 166(3–4), 676–680. https://doi.org/10.1016/j.vetmic.2013.07.007
Rocha-Gracia, R. C., Cortés-Cortés, G., Lozano-Zarain, P., Bello, F., Martínez-Laguna, Y., & Torres, C. (2015). Faecal Escherichia coli isolates from healthy dogs harbour CTX-M-15 and CMY-2 β-lactamases. The Veterinary Journal, 203(3), 315–319. https://doi.org/10.1016/j.tvjl.2014.12.026
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