Effect of chia (Salvia hispanica L.) seed extract on wound healing in mice.
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Abstract
Abstract
Background: Salvia hispanica L. either commonly known as chia or chia seed is the Lamiaceae family native to central and southern America. Seed from chia contains high rich omega 3, 6, and phenolic acid; and can help in cardiovascular and inflammatory skin disease including wound healing. However, the benefits of wound healing have been limited, so chia seed need to validate a pharmacological activity. The current study is designed to evaluate the effect of chia seed extract using as topical drug on wound healing in mice.
Materials and methods: Male BALB/cAJcl mice were divided into 4 groups (n = 24), and then were created 6 mm circular excision wounds. All mice were treated for 9 consecutive days post-wounding with four topical applications of the mixtures: polyethylene glycol, 4% chia seed extract, 8% chia seed extract, and 1% silver sulfadiazine. The investigated parameters were the percentage of wound contraction and histopathological examination.
Results: Wound contraction increased significantly on day 9 in groups of 8% v/v chia seed extract, 4% v/v chia seed extract, and 1% silver-sulfadiazine, rising to 97.98, 97.14, 89.17 percent respectively, compared to the polyethylene glycol group, 76.49 (P<0.001). Moreover, histopathological studies also obviously revealed a potential wound healing, with infiltration of a number of fibroblasts, collagen, and vessels in the treated groups.
Conclusions: Chia seed extract was a good natural plant which able to be used as topical for wound healing.
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