Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs https://doi.org/10.12982/VIS.2021.033

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Published: Jun 15, 2021
Keywords:
IL17RA Litter size Non-synonymous SNP Pig

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Worrarak Norseeda
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand Center of Excellence on Agricultural Biotechnology: (AG-BIO/MHESI), Bangkok 10900, Thailand Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand
Guisheng Liu
Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan 430064, China Hubei Key Lab for Animal Embryo Engineering and Molecular Breeding, Wuhan 430064, China
Tawatchai Teltathum
Mae Hong Son Livestock Research and Breeding Center, Mae Hong Son 58000, Thailand
Korawan Sringarm
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand
Watcharapong Naraballobh
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Trisadee Khamlor
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand
Supamit Mekchay
Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200 Center of Excellence on Agricultural Biotechnology: (AG-BIO/MHESI), Bangkok 10900, Thailand Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand

Abstract

Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of mammals. The purposes of this study were to examine polymorphisms in the porcine IL17RA gene and to assess its effects on litter size traits in Large White and Landrace pigs. Three non-synonymous single nucleotide polymorphisms (SNPs) in the porcine IL17RA gene were verified. The porcine IL17RA c.785C>T (p.Ala262Val) was found to be segregating in the Large White and Landrace pigs. No polymorphisms in the coding region of the porcine IL17RA gene at the two non-synonymous SNPs loci of c.997G>A (p.Val333Ile) and c.1962T>G (p.Asp654Glu) were found. The porcine IL17RA c.785C>T polymorphism was significantly associated with the total number born (TNB) and the number born alive (NBA) in Large White pigs (P<0.05). Moreover, the porcine IL17RA c.785C>T was significantly associated with the TNB, NBA, total birth weight (TBW), and total weaning weight of piglets at 21 days (TWW) in Landrace pigs (P<0.05). These results supported the importance of the porcine IL17RA gene in the litter size traits of pigs. Thus, the porcine IL17RA could be used as a potential candidate gene for improving litter size traits in pig breeding

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How to Cite
Norseeda, W. ., Liu, G. ., Teltathum, T. ., Sringarm, K. ., Naraballobh, W. ., Khamlor, T. ., & Mekchay, S. . (2021). Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs: https://doi.org/10.12982/VIS.2021.033. Veterinary Integrative Sciences, 19(3), 391–405. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/251558
Issue
Vol. 19 No. 3 (2021): September-December
Section
Research Articles
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