Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology

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Duong Tien Thach
Bui Khac Cuong
Hoang Van Tong
Vo Van Chi
Ngo Kim Khue
Nguyen Thi Phuong Hien
Nong Van Hai
Yves Combarnous
Thi Mong Diep Nguyen


Equine Chorionic Gonadotropin (eCG) previously named Pregnant Mare Serum Gonadotropin (PMSG) has been widely used since the 40s in animal reproduction control. It is extracted from the blood of pregnant mares between days 40 and 120 of gestation. Animal welfare organizations have voiced concerns against mares bleeding conditions. There is currently no effective substitute for the natural PMSG. In this review, we summarize the basic knowledge of the structure and biology of eCG, and the research on recombinant eCG production in the past five years.

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Tien Thach, D. ., Khac Cuong, B. ., Van Tong, H. ., Van Chi, V. ., Kim Khue, N. ., Thi Phuong Hien, N. ., Van Hai, N. ., Combarnous, Y. ., & Mong Diep Nguyen, T. . (2022). Natural and recombinant equine chorionic gonadotropins past and future in animal reproductive technology: Veterinary Integrative Sciences, 20(3), 751–760. Retrieved from
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