Antibiotics in broilers chicken production: a review of impacts, challenges and potential alternatives https://doi.org/10.12982/VIS.2024.039
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Abstract
Globally, the use of antibiotic in animal industry was well known in the 20th century. Antibiotics usage as therapeutic and subtherapeutic means of improving growth and feed efficiency in livestock was well documented in literature. However, continuous use of antibiotics in food animals for increased growth and disease prevention has resulted in the development of antibiotic resistant bacteria in animals. This has led to disease treatment failure in the affected animals. The problem of transmission of antibiotic resistant bacteria to human through food chain and contamination of environment is another challenge of antibiotic usage in poultry production. Hence, the ban was placed on antibiotic usage in animal production. The restriction to the use of animal growth promoting antibiotic has gained high compliance in the developed countries. However, in the third world countries, this is still a battle that is on-going. To achieve the 2023 Global Action Plan on Antimicrobial Resistance goal, a lot is still left to be done. This review synthesized information on implications of antibiotics use on broiler chickens’ production cost efficiency and profitability; impact of antibiotics mode of action, diseases prevention and treatments of infection in broiler chickens’ production; challenges of antibiotics residual effect on meat quality and safety and alternatives to synthetic antibiotic for broiler chickens’ production.
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References
Abbaszadeh, S., Sharifzadeh, A., Shokri, H., Khosravi, A., Abbaszadeh, A., 2014. Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi. J Med. Mycol. 24, e51-e56
Acar, J.F., Moulin, G., 2006. Antimicrobial resistance at farm level. Rev. Sci. Tech. 25, 775–792.
Akpodiete, O.J., Okagbara, G.O., Omeje, S.I., Orogun, J.A., 2001. Effect of roasting, boiling and boiling with potash on soyabean and its utilization by finishing broilers.
In Proceedings of the 6th Annual conference of animal science association of Nigeria, Maiduguri, pp. 50-52.
Alabi, O.J., Malik, A.D., Ng’ambi, J.W., Obaje, P., Ojo, B.K., 2017. Effect of aqueous moringa oleifera (lam) leaf extracts on growth performance and carcass characteristics of hubbard broiler chicken. Braz. J. Poultry. Sci. 19, 273-279.
Alfaro, D.M., Silva, A.V.F, Borges, S.A., Maiorka, F.A., Vargas, S., Santin E., 2007. Use of Yucca schidigera extract in broiler diets and its effects on performance results obtained with different coccidiosis control methods. J. Appl. Poult. Res. 16, 248-
Al-Khalaifa, H., Al-Nasser, A., Al-Surayee, T., Al-Kandari, S., Al-Enzi, N., Al-Sharrah, T.,Ragheb, G., Al-Qalaf, S., Mohammed, A., 2019. Effect of dietary probiotics and prebiotics on the performance of broiler chickens. Poult. Sci. 98, 4465-4479.
Amad, A.A., Manner, K., Wendler, K.R., Neumann, K., Zentek, J., 2011. Effects of a phytogenic feed additive on growth performance and ileal nutrient digestibility in broiler chickens. Poult. Sci. 90, 2811-2816.
Araujo, R.G., Polycarpo, G., Barbieri, A., Silva, K.M., Ventura, G., Polycarpo, V., 2019.Performance and economic viability of broiler chickens fed with probiotic and organic acids in an attempt to replace growth-promoting antibiotics. Braz. J. Poultry.
Sci. 21(2), 1-8.
Awad, A., Gwida, M., Khalifa, E., Sadat, A., 2020. Phenotypes, antibacterial-resistant profile,and virulence-associated genes of Salmonella serovars isolated from retail chicken meat in Egypt. Vet. World. 13, 440.
Batista, L.S., Garcia, E.A., Faitarone, A.B.G., Sherer, M.R., Mori, C., Pelicia, K., Pizzolante, C.C., 2007. Flavonoids and mannanoligosaccharides in broiler diets. Braz. J. Poult. Sci. 9, 33-37.
Baurhoo, B., Phillip, L., Ruiz-Feria, C.A., 2007. Effects of purified lignin and mannan oligosaccharides on intestinal integrity and microbial populations in the ceca and litter of broiler chickens. Poult. Sci. 86, 1070–1078.
Bedada, A.H., Zewde, B.M., Molla Zewde, B.M., 2012. Tetracycline residue levels in slaughtered beef cattle from three slaughterhouses in Central Ethiopia. Glob. Vet. 8,546–554.
Bedford, M.R., Cowieson, A.J., 2012. Exogenous enzymes and their effects on intestinal microbiology. Anim. Feed Sci. Technol. 173, 76-85.
Benites, V., Gilharry, R., Gernat, A.G., Murillo, J.G., 2008. Effect of dietary mannan oligosaccharide from Bio-Mos or SAF-Mannan on live performance of broiler chickens. J. Appl. Poult. Res. 17, 471–475.
Bosha, J.O., Akwuobu, C.A., Onyeyili, P.A., 2019. Determination of tetracycline residues in broilers reared in Makurdi Metropolis, Nigerian. Vet. J. 40, 315-325.
Bozkurt, M., Kucukyilmaz, K., Katli, A.U., Cinar, M., 2008. Growth performance and slaughter characteristics of broiler chickens fed with antibiotic, mannan oligosaccharide and dextrin oligosaccharide supplemented diets. Int. J. Poult. Sci. 7,969-977.
Brennan, K., Paul, M., Samuel, R., Lumpkins, B., Pierce, J., Collett, S., Mathis, G.,2013. Comparison of performance and intestinal morphology of broilers using stepdown supplementation with a mannan-rich fraction versus bacitracin methylene disalicylate. J. Appl. Anim. Nutr. 2, E12.
Brown, K., Uwiera, R.R., Kalmokoff, M.L., Brooks, S.P., Inglis, G.D., 2017. Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives. Int. J. Antimicrob. Agents. 49, 12-24.
Cabuk, M., Alcicek, A., Bozkurt, M., Akkan, S., 2004. Effect of yucca schidigeraand natural zeolite on broiler performance. Int. J Poult Sci. 3(10), 651-654.
Cengiz, O., Koksal, B.H., Tatlı, O., Sevim, O., Ahsan, U., Uner, A.G., Ulutaş, P.A., Beyaz,D., Buyukyoruk, S., Yakan, A., Onol, A.G., 2015. Effect of dietary probiotic and high stocking density on the performance, carcass yield, gut microflora, and stress
indicators of broilers. Poult. Sci. 94, 2395-2403.
Chen, K.L., Kho, W.L., You, S.H., Yeh, R.H., Tang, S.W., Hsieh, C.W., 2009. Effects of Bacillus subtilis var. natto and Saccharomyces cerevisiae mixed fermented feed on the enhanced growth performance of broilers. Poult. Sci. 88, 309-315.
Cheong, C.K., Hajeb, P., Jinap, S., Ismail-Fitry, M.R., 2010. Sulfonamides determination in chicken meat products from Malaysia. Int. Food Res. J. 17, 885-892.
Chopra, I., Roberts, M., 2001. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol. Mol. Biol.Rev. 65, 232–260.
Chowdhury, R., Islam, K.M.S., Khan, M.J., Karim, M.R., Haque, M.N., Khatun, M., Pesti,G.M., 2009. Effect of citric acid, avilamycin, and their combination on the performance, tibia ash, and immune status of broilers. Poult. Sci. 88, 1616-1622.
Christy, M., Sampson, M., Edson, M., Anthony, O., 2018. Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules. 23, 795.
Clement, M., Olabisi, M., David, E., Issa, M., 2019. Veterinary pharmaceuticals and antimicrobial resistance in developing countries. Available online: https://www.intechopen.com/chapters/66512
Costa, A.I.A., Teldeschi, E., Gerritzen, M.A., Reimert, H.G.M., Linssen, J.P.H., Cone, J.W.,2007. Influence of flock treatment with the antibiotic tylosin on poultry meat quality: Results of a preliminary experiment. NJAS - Wageningen J. Life. Sci. 54(3),269-278.
Cowieson, A.J., Kluenter, A.M., 2019. Contribution of exogenous enzymes to potentiate the removal of antibiotic growth promoters in poultry production. Anim. Feed Sci.Technol. 250, 81-92.
Cully, M., 2014. Public health: the politics of antibiotics. Nature, 509(7498), S16-S17.
Dipeolu, M.A., Dada, K., 2006. Residues of tetracycline in imported frozen chickens in South West Nigeria. Trop. Vet. 23(1), 1-4.
Elisha, I.L., Botha, F.S., McGaw, L.J., Eloff, J.N., 2017. The antibacterial activity of extracts of nine plant species with good activity against Escherichia coli against five other bacteria and cytotoxicity of extracts. BMC. Complement. Altern. Med. 17(133), 1-10.
Er, B., Onurdag, F.K., Demirhan, B., Ozgacar, S., Oktem, A.B., Abbasoglu, U., 2013. Screening of quinolone antibiotic residues in chicken meat and beef sold in the markets of ankara, turkey. Poult. Sci. 92(8), 2212-2215.
Etebu, E., Arikekpar, I., 2016. Antibiotics: classification and mechanisms of action with emphasis on molecular perspectives. Int. J. Appl. Microbiol. Biotechnol. Res. 4, 90-101.
Fernebro, J., 2011. Fighting bacterial infections-future treatment options. Drug. Resist.Updat. 14(2), 125-139.
Frey-Klett, P., Burlinson, P., Deveau, A., Barret, M., Tarkka, M., Sarniguet, A., 2011. Bacterial-fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists. Microbiol. Mol. Biol. Rev. 75, 583-609.
Fuller, R., 1989. Probiotics in man and animals. J. Appl. Bacteriol. 66, 365–378.
Gadde, U., Kim, W.H., Oh, S.T., Lillehoj, H.S., 2017. Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review. Anim.Health. Res. Rev. 18, 26-45.
Gaurav, A.K., 2015. Studies on supplementation of Chlorophytum root and Camellia seed as feed additives in broiler ration (M.V.Sc. Thesis). Deemed University, Indian Veterinary Research Institute, pp. 50-61.
Gudev, D., Popova- Ralcheva, S., Moneva, P., Bonovska, M., Valchev, G., Valcheva, A., 2004. Effect of supplemental Sangrovit on some biochemical indices and leukocytes phagocytic activity in growing pigs. Archiva. Zootechnica. 7, 123–134.
Guetiya Wadoum, R.E., Zambou, N.F., Anyangwe, F.F., Njimou, J.R., Coman, M.M.,Verdenelli, M.C., Cecchini, C., Silvi, S., Orpianesi, C., Cresci, A., Colizzi, V., 2016.
Abusive use of antibiotics in poultry farming in Cameroon and the public health implications. Br. Poult. Sci. 57(4), 483-493.
Habeeb, M.L., Opasola, A.O., Garba, M., Olalekan, M.R., 2022. A wake-up call: determination of antibiotics residue level in raw meat in abattoir and selected slaughterhouses in five local government in Kano State, Nigeria. J. Vet. Health. Sci.3, 54-61.
Hashemipour, H., Kermanshahi, H., Golian, A., Veldkamp, T., 2013. Effect of thymol and carvacrol feed supplementation on performance, antioxidant enzyme activities, fatty acid composition, digestive enzyme activities, and immune response in broiler chickens. Poult. Sci. 92, 2059-2069.
Hossan, M.D., Khan, S.H., Kazi, M.K., Anwarul, H.B., 2018. Global restriction of using antibiotic growth promoters and alternative strategies in poultry production. Sci.Prog 101, 52–75.
Hutkins, R.W., Krumbeck, J.A., Bindels, L.B., Cani, P.D., Fahey, G., Jr, Goh, Y.J., Hamaker,B., Martens, E.C., Mills, D.A., Rastal, R.A., Vaughan, E., Sanders, M.E., 2016.Prebiotics: why definitions matter. Curr. Opin. Biotechnol. 37, 1–7.
Iskender, H., Yenice, G., Dokumacioglu, E.I., Kaynar, O., Hayirli, A., Kaya, A., 2016. The effects of dietary flavonoid
supplementation on the antioxidant status of laying hens.Braz. J. Poult. Sci. 18, 663–668.
Jankowski, J., Zdunczyk, Z., Juskiewicz, J., Kozłowski, K., Lecewicz, A., Jeroch, H., 2009.Gastrointestinal tract and metabolic response of broilers to diets with the Macleaya cordata alkaloid extract. Archiv. fur. Geflugelkunde. 73, 95–101.
Juskiewicz, J., Gruzauskas, R., Zdunczyk, Z., Semaskaite, A., Jankowski, J., Totilas, Z.,Jarule, V., Sasyte, V., Zdunczyk, P., Raceviciute-Stupeliene, A., Svirmickas, G.,2011. Effects of dietary addition of macleaya cordata alkaloid extract on growth performance, caecal indices and breast meat fatty acids profile in male broilers. J.Anim. Physiol. Anim. Nutr. (Berl). 95(2), 171-178.
Kim, D.K., Lillehoj, H.S., Lee, S.H., Lillehoj, E.P., Bravo, D., 2013. Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites. Br. J. Nutr. 109(1), 76-88.
Kim, G.B., Seo, Y.M., Kim, C.H., Paik, I.K., 2011. Effect of dietary prebiotic supplementation on the performance, intestinal microflora, and immune response of broilers. Poult. Sci. 90, 75–82.
Kimera, Z.I., Mdegela, R.H., Mhaiki, C.J.N., Karimuribo, E.D., Mabiki, F., Nonga, H.E.,Mwesongo, J., 2015. Determination of oxytetracycline residues in cattle meat marketed in the Kilosa district, Tanzania. Onderstepoort. J. Vet. Res. 82(1), 911.
Kogut, M.H., Arsenault, R.J., 2016. Editorial: gut health: the new paradigm in food animal production. Front. Vet. Sci. 3, 71.
Laxminarayan, R., Van, Boeckel, T., Teillant, A., 2015. The economic costs of withdrawing antimicrobial growth promoters from the livestock sector. Available online: https://www.oecd-ilibrary.org/agriculture-and-food/the-economic-costs-of-withdrawinganti-microbial-use-in-the-livestock-sector_5js64kst5wvl-en
Lee, K., Lillehoj, H.S., Siragusa, G.R., 2010. Direct-fed microbials and their impact on the intestinal micro flora and immune system of chickens. J. Poult. Sci. 47, 106-114
Lee, K.W., Lillehoj, H.S., Lee, S.H., Jang, S.I., Park, M.S., Bautista, D.A., Ritter, G.D.,Hong, Y.H., Siragusa, G.R., Lillehoj, E.P., 2012. Effect of dietary antimicrobials on immune status in broiler chickens. Asian-Australas J Anim. Sci. 25, 382-392.
MacDonald, J.M., Wang, S.L., 2011. Foregoing Sub-therapeutic Antibiotics: the Impact on Broiler Grow-out Operations. Appl. Econ. Perspect. Policy. 33, 79–98.
Manafi, M., Hedayati, M., Khalaji, S., 2016. Effectiveness of phytogenic feed additive as alternative to bacitracin methylene disalicylate on hematological parameters,intestinal histomorphology and microbial population and production performance of
Japanese quails. Asian-Australas. J. Anim. Sci. 29, 1300-1308.
Manyi-Loh, C., Mamphweli, S., Meyer, E., Okoh, A., 2018. Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules. 23(4), 795.
Mehdi, Y., Letourneau-Montminy, M.P., Gaucher, M.L., Chorfi, Y., Suresh, G., Rouissi,T., Brar, S.K., Cote, C., Ramirez, A.A., Godbout, S., 2018. Use of antibiotics in broiler production: global impacts and alternatives. Anim. Nutr. 4, 170-178.
Miah, M.Y., Rahman, M.S., Islam, M.K., Monir, M.M., 2004. Effects of saponin and l-carnitine on the performance and reproductive fitness of male broiler. Int. J Poult. Sci. 3, 530- 533.
Muhammad, J., Khan, S., Su, J.Q., Hesham, A.E.L., Ditta, A., Nawab, J., Ali, A., 2020. Antibiotics in poultry manure and their associated health issues: a systematic review.J. Soils. Sediments. 20, 486-497.
Muriuki, F.K., Ogara, W.O., Njeruh, F.M., Mitema, E.S., 2001. Tetracycline residue levels in cattle meat from Nairobi slaughter house in Kenya. J. Vet. Sci. 2, 97–101
Nchima, G., Choongo, K., Muzandu, K., Nalubamba, K., Muma, J., Bumbangi, F., Monga,G., Kangwa, H., 2017. Determination of oxytetracycline and sulphamethazine residues in marketed beef from selected parts of Zambia to assess compliance with
maximum residual limits. Am. J. Res. Commun. 5, 42–64.
Nirala, R.K., Anjana, K., Mandal, K.G., Jayachandran, C., 2017. Persistence of antibiotic residue in milk under Region of Bihar, India. Int. J. Curr. Microbiol. Appl. Sci. 6,2296-2299
Nkengasong, J.N., Maiyegun, O., Moeti, M., 2017. Establishing the Africa Centres for Disease Control and Prevention: responding to Africa’s health threats. Lancet. Glob. Health. 5, e246–e247.
Nunes, R.V., Scherer, C., Pozza, P.C., Eyng, C., Bruno, L.D.G., Vieites, F.M., 2012. Use of probiotics to replace antibiotics for broilers. R. Bras. Zootec. 41, 2219-2224.
Okorie-Kanu, O.J., Anyanwu, M.U., Ezenduka, E.V., Mgbeahuruike, A.C., Thapaliya, D.,Gerbig, G., Ugwuijem, E.E., Okorie-Kanu, C.O., Agbowo, P., Olorunleke, S.,Nwanta, J.A., 2020. Molecular epidemiology, genetic diversity and antimicrobial resistance of Staphylococcus aureus isolated from chicken and pig carcasses, and carcass handlers. Plos one. 15, e0232913.
Olatoye, I.O., Daniel, O.F., Ishola, S.A., 2016. Screening of antibiotics and chemical analysis of penicillin residue in fresh milk and traditional dairy products in Oyo state, Nigeria. Vet. World. 9, 948–954
Olatoye, O.I., Ojomo, T.O., Adeseko, Y.J., 2019. Antibiotics use and gentamicin residues in commercial poultry and chicken eggs from Oyo and Lagos States, Nigeria. Revue. Elev. Med. Vet. Pays. Trop. 72(4), 161-165.
Olufemi, O.I., Agboola, E.A., 2009. Oxytetracycline residues in edible tissues of cattle slaughtered in Akure, Nigeria. Internet J. Food Saf. 11, 62–66.
Olusola, A.V., Diana, B.E., Ayoade, O.I., 2012. Assessment of tetracycline, lead and cadmium residues in frozen chicken vended in Lagos and Ibadan, Nigeria. Pak. J Biol. Sci. 15, 839-844.
Onipede, O.J., Nwankwo, B., Adewuyi, G.O., Nwachukwu, C.U., 2021. Levels of antibiotics residues in chicken and catfish sold in some parts of Lagos state and Ota local government Ogun state south-western Nigeria. Sci. Afr. 12, e00768.
Onyeanu, C.T., Ezenduka, E.V., Anaga, A.O., 2020. Determination of gentamicin use in poultry farms in Enugu state, Nigeria, and detection of its residue in slaughter commercial broilers. Int. J. One Health. 6, 6-11.
Pasaribu, T., Astuti, D.A., WIna, E., Sumiati, S., Setiyono, A. 2014. Milled lerak (Sapindus rarak) as feed additive and its effects on the performance and lipid profile of broiler infected by Eimeria tenella. J. Ilmu. peternak. Vet. Tropis. 19, 263-271.
Pourabedin, M., Xu, Z., Baurhoo, B., Chevaux, E., Zhao, X., 2014. Effects of mannan oligosaccharide and virginiamycin on the cecal microbial community and intestinal morphology of chickens raised under suboptimal conditions. Can. J. Microbiol. 60,
-266.
Qin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., Wu, M., 2022. Pseudomonas aeruginosa: Pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics. Signal.
Transduct. Target. Ther. 7(1), 199.
Rushton, J., 2015. Anti-microbial use in animals: How to assess the trade-offs. Zoonoses. Public. Health. 62 Suppl 1(Suppl 1), 10-21.
Salama, N.A., Abou-Raya, S.H., Shalaby, A.R., Emam, W.H., Mehaya, F.M., 2011. Incidence of tetracycline residues in chicken meat and liver retailed to consumers. Food. Addit Contam Part B Surveill. 4(2), 88–93.
Shanmugasundaram, R., Selvaraj, R.K., 2012. Effect of killed whole yeast cell prebiotic supplementation on broiler performance and intestinal immune cell parameters.Poult. Sci. 91, 107-111
Shobrak, M.Y., Abo-Amer, A.E., 2014. Role of wild birds as carriers of multi-drug resistant Escherichia coli and Escherichia vulneris. Braz. J. Microbiol. 45, 1199–1209.
Sneeringer, S., Macdonald, J.M., Key, N., McBride, W.D., Mathews, K.H., 2015. Economics of antibiotic use in U.S. livestock production. Available online: https://www.ers.usda.gov/webdocs/publications/45485/err-200.pdf
Su, J.L., Shi, B.L., Zhang, P.F., Sun, D.S., Li, T.Y., Yan, S.M., 2016. Effects of Yucca extract on feed efficiency, immune and antioxidative functions in broilers. Braz. Arch. Biol.Technol. 59, e16150035.
Tavakoli, H.R., Safaeefirouzabadi, M.S., Afsharfarnia, S., Joneidijafari, N., Saadat, S., 2015.Detecting antibiotic residues by HPLC method in chicken and calves’ meat in diet of a Military Center in Tehran. Acta Med. Mediterr. 31, 1427–1433.
Thacker, P.A., 2013. Alternatives to antibiotics as growth promoters for use in swine production: a review. J. Anim. Sci. Biotechnol. 4(1), 35.
Thames, H., Sukumaran, A., 2020. A review of salmonella and campylobacter in broiler meat: emerging challenges and food safety measures. Foods. 9, 776.
Timmerman, H.M., Koning, C.J., Mulder, L., Rombouts, F.M., Beynen, A.C., 2004.Monostrain, multistrain and multispecies probiotics-A comparison of functionality and efficacy. Int. J. Food. Microbiol. 96, 219-233.
Tomer, K., Sethiya, N.K. Shete, A., Singh, V., 2010. Isolation and characterization of total volatile components from leaves of Citrus limon linn. J. Adv. Pharm. Technol. Res.1, 49-55.
Vanisree, M., Lee, C.Y., Lo, S.F., Nalawade, S.M., Lin, C.Y., Tsay, H.S., 2004. Studies on the production of some important secondary metabolites from medicinal plants by plant tissue cultures. Bot. Bull. Acad. Sin. 45, 1-22.
Vidic, J., Manzano, M., Chang, C.M., Jaffrezic-Renault, N., 2017. Advanced biosensors for detection of pathogens related to livestock and poultry. Vet. Res. 48, 1-22.
Vincken, J.P., Heng, L., de Groot, A., Gruppen, H., 2007. Saponins, classification and occurrence in the plant kingdom. Phytochemistry. 68, 275–297.
Wegener, H.C., 2012. Antibiotic Resistance: Linking humans and animal health. Available online: https://www.ncbi.nlm.nih.gov/books/NBK114485/
WHO, 2002. Impacts of antimicrobial growth promoter termination in Denmark. Available online:https://iris.who.int/bitstream/handle/10665/68357/WHO_CDS_CPE_ZFK_20 03.1.pdf?sequence=1&isAllowed=y
WHO, 2001. World Health Organization WHO global strategy for containment of antimicrobial resistance. WHO, Geneva.
WHO, 2015. World Health Organization. Global action plan on antimicrobial resistance.Geneva. Available online: https://www.who.int/antimicrobial-resistance/globalaction-plan/en/.
Windisch, W., Schedle, K., Plitzner, C., Kroismayr, A., 2008. Use of phytogenic products as feed additives for swine and poultry. J. Anim. Sci. 86, E140–E148.
Wu, B.Q., Zhang, T., Guo, L.Q., Lin, J.F., 2011. Effects of Bacillus subtilis KD1 on broiler intestinal flora. Poult. Sci. 90, 2493-2499.
Xue, G.D., Wu, S.B., Choct, M., Pastor, A., Steiner, T., Swick, R.A., 2017. Impact of a Macleaya cordata-derived alkaloid extract on necrotic enteritis in broilers. Poult.Sci. 96, 3581‐3585.
Yadav, S., Jha, R., 2019. Strategies to modulate the intestinal microbiota and their effects on nutrient utilization, performance, and health of poultry. J. Anim. Sci. Biotechnol. 10, 1-11.
Yakhkeshi, S., Rahimi, S., Gharib Naseri, K., 2011. The effects of comparison of herbal extracts, antibiotic, probiotic and organic acid on serum lipids, immune response, GIT microbial population, intestinal morphology and performance of broilers. J.
Med. Plant Res. 10, 80–95.
Yang, Q.E., Walsh, T.R., 2017. Toxin–antitoxin systems and their role in disseminating and maintaining antimicrobial resistance. FEMS Microbiol. Rev. 41, 343-353.
Zheng, N., Wang, J., Han, R., Xu, X., Zhen, Y., Qu, X., Sun, P., Li, S., Yu, Z., 2013. Occurrence of several main antibiotic residues in raw milk in 10 provinces of China.Food. Addit. Contam. 6, 84–89.