The General and Systemic Consequences of Obesity in Cats and Dogs https://doi.org/10.12982/VIS.2024.020

Main Article Content

Wajahat Masood

Abstract

Obesity, is a life-threatening condition common among various animals, is a multisystemic disorder that may affect the gastrointestinal system, urinary system, reproductive system, respiratory system, and musculoskeletal system. According to various studies, more than 50% of cats and dogs are obese. Many proinflammatory and inflammatory cytokines, hormones, and enzymes play a part in the production of fat tissues that lead to obesity. Excessive deposition of fats give rise to conditions involving inflammation, oxidative stress and damage, immunomodulation, hyperlipidemia, dyslipidemia, neoplasia, hypothyroidism, and insulin resistance. This review paper acquires the knowledge of various scientific manuscripts to discuss the development and consequences of obesity in pets especially cats and dogs

Article Details

How to Cite
Masood, W. (2023). The General and Systemic Consequences of Obesity in Cats and Dogs: https://doi.org/10.12982/VIS.2024.020. Veterinary Integrative Sciences, 22(1), 265–250. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/264066
Section
Review Article

References

Abella V, Scotece M, Conde J, Pino J, Gonzalez-Gay MA, Gomez-Reino JJ, Mera A, Lago F, Gomez R, Gualillo O. 2017 Leptin in the interplay of inflammation, metabolism and immune system disorders. Nature Reviews Rheumatology 13, 100-9,

Adolphe JL, Silver TI, Childs H, Drew MD, Weber LP. 2014 Short-term obesity results in detrimental metabolic and cardiovascular changes that may not be reversed with weight loss in an obese dog model. British journal of nutrition 112, 647-56,

Agudelo-Giraldo L, Narváez-Solarte W. 2019 PREVALENCE OF OBESITY ON Canis lupus familiaris Linnaeus, 1758 (Carnivora: Canidae) IN MANIZALES, COLOMBIA. Boletín Científico. Centro de Museos. Museo de Historia Natural 23, 235-44,

Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-2,

Alenza DP, Rutteman GR, Peña L, Beynen AC, Cuesta P. 1998 Relation between habitual diet and canine mammary tumors in a case‐control study. Journal of Veterinary Internal Medicine 12, 132-9,

Alexander LG, Salt C, Thomas G, Butterwick R. 2011 Effects of neutering on food intake, body weight and body composition in growing female kittens. British journal of nutrition 106, S19-S23,

Allan F, Pfeiffer D, Jones B, Esslemont D, Wiseman M. 2000 A cross-sectional study of risk factors for obesity in cats in New Zealand. Preventive veterinary medicine 46, 183-96,

Amirkhizi F, Siassi F, Minaie S, Djalali M, Rahimi A, Chamari M. 2010 Is obesity associated with increased plasma lipid peroxidation and oxidative stress in women? ARYA Atherosclerosis Journal 2,

Anderson D. 1996 Antioxidant defences against reactive oxygen species causing genetic and other damage. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 350, 103-8,

Anonymous.2018 APOP. https://petobesityprevention.org/2018

Anthony K, Reed LJ, Dunn JT, Bingham E, Hopkins D, Marsden PK, Amiel SA. 2006 Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome? Diabetes 55, 2986-92,

Antoniou N. 2019 Analysis of dog obesity in Cyprus Paphos X small animal clinic.

Antuna-Puente B, Feve B, Fellahi S, Bastard J-P. 2008 Adipokines: the missing link between insulin resistance and obesity. Diabetes & metabolism 34, 2-11,

Arena L, Menchetti L, Diverio S, Guardini G, Gazzano A, Mariti C. 2021 Overweight in Domestic Cats Living in Urban Areas of Italy: Risk Factors for an Emerging Welfare Issue. Animals 11, 2246,

Armağan C, Yılmaz C, Koç A, Abacı A, Ülgenalp A, Böber E, Erçal D, Demir K. 2019 A toddler with a novel LEPR mutation. Hormones 18, 237-40,

Arora S. 2006 Role of neuropeptides in appetite regulation and obesity–a review. Neuropeptides 40, 375-401,

Baba E, Arakawa A. 1984 Myocardial hypoxia in an obese beagle. VETERINARY MEDICINE & SMALL ANIMAL CLINICIAN 79, 788-&,

Bach JF, Rozanski EA, Bedenice D, Chan DL, Freeman LM, Lofgren JL, Oura TJ, Hoffman AM. 2007 Association of expiratory airway dysfunction with marked obesity in healthy adult dogs. American journal of veterinary research 68, 670-5,

Backus R. 2011 Plasma oestrogen changes in adult male cats after orchiectomy, body-weight gain and low-dosage oestradiol administration. British journal of nutrition 106, S15-S8,

Backus R, Kanchuk M, Rogers Q. 2006 Elevation of plasma cholecystokinin concentration following a meal is increased by gonadectomy in male cats. Journal of animal physiology and animal nutrition 90, 152-8,

Badman MK, Flier JS. 2007 The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 132, 2103-15,

Balistreri CR, Caruso C, Candore G. 2010 The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators of inflammation 2010,

Barton M, Carmona R, Ortmann J, Krieger JE, Traupe T. 2003 Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. The international journal of biochemistry & cell biology 35, 826-37,

Bastard J-P, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. 2006 Recent advances in the relationship between obesity, inflammation, and insulin resistance. European cytokine network 17, 4-12,

Bastien BC, Patil A, Satyaraj E. 2015 The impact of weight loss on circulating cytokines in Beagle dogs. Veterinary immunology and immunopathology 163, 174-82,

Batra A, Okur B, Glauben R, Erben U, Ihbe J, Stroh T, Fedke I, Chang H-D, Zeitz M, Siegmund B. 2010 Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo. Endocrinology 151, 56-62,

Belotta A, Teixeira C, Padovani C, Rahal S, Mayer M, Mamprim M. 2018 Sonographic evaluation of liver hemodynamic indices in overweight and obese dogs. Journal of Veterinary Internal Medicine 32, 181-7,

Belsito K, Vester B, Keel T, Graves T, Swanson K. 2009 Impact of ovariohysterectomy and food intake on body composition, physical activity, and adipose gene expression in cats. Journal of animal science 87, 594-602,

Bensaid M, Gary-Bobo M, Esclangon A, Maffrand J, Le Fur G, Oury-Donat F, Soubrie P. 2003 The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Molecular pharmacology 63, 908-14,

Berg L, De Koning D-J, Fall N, Hansson H, Herlin AH, Hirsch E, Hultgren J, Jacobson M, Jensen P, Keeling L. 2020 Hållande av hund och katt.

Bermingham EN, Thomas DG, Cave NJ, Morris PJ, Butterwick RF, German AJ. 2014 Energy requirements of adult dogs: a meta-analysis. PloS one 9, e109681,

Bermingham EN, Thomas DG, Morris PJ, Hawthorne AJ. 2010 Energy requirements of adult cats. British journal of nutrition 103, 1083-93,

Bernotiene E, Palmer G, Gabay C. 2006 The role of leptin in innate and adaptive immune responses. Arthritis research & therapy 8, 1-10,

Bharadwaj D, Stein M-P, Volzer M, Mold C, Clos TWD. 1999 The major receptor for C-reactive protein on leukocytes is Fcγ receptor II. The Journal of experimental medicine 190, 585-90,

Bland I, Guthrie-Jones A, Taylor R, Hill J. 2009 Dog obesity: owner attitudes and behaviour. Preventive veterinary medicine 92, 333-40,

Bodey AR, Michell A. 1996 Epidemiological study of blood Sressure in omestic dogs. Journal of Small Animal Practice 37, 116-25,

Bouthegourd J-C, Kelly M, Clety N, Tardif S, Smeets D. 2009 Effects of weight loss on heart rate normalization and increase in spontaneous activity in moderately exercised overweight dogs. The Journal of Applied Research in Veterinary Medicine 7, 153,

Brady RB, Sidiropoulos AN, Bennett HJ, Rider PM, Marcellin-Little DJ, DeVita P. 2013 Evaluation of gait-related variables in lean and obese dogs at a trot. American journal of veterinary research 74, 757-62,

Brennan C, Hoenig M, Ferguson D. 2004 GLUT4 but not GLUT1 expression decreases early in the development of feline obesity. Domestic animal endocrinology 26, 291-301,

Brewster UC, Perazella MA. 2004 The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease. The American journal of medicine 116, 263-72,

Brinson J, McKiernan B. 1998 Respiratory function in obese dogs with chronic respiratory disease and their response to treatment. J Vet Intern Med 12, 209,

Brown DC, Conzemius M, Shofer F. 1996 Body weight as a predisposing factor for humeral condylar fractures, cranial cruciate rupture and intervertebral disc disease in Cocker Spaniels. Veterinary and Comparative Orthopaedics and Traumatology 9, 75-8,

Bruno A, Conus S, Schmid I, Simon H-U. 2005 Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. The Journal of Immunology 174, 8090-6,

Brunson BL, Zhong Q, Clarke KJ, Bedi D, Braden TD, van Santen E, Judd RL. 2007 Serum concentrations of adiponectin and characterization of adiponectin protein complexes in dogs. American journal of veterinary research 68, 57-62,

Burger IH, Johnson JV. 1991 Dogs large and small: the allometry of energy requirements within a single species. The Journal of nutrition 121, S18-S21,

Cachofeiro V, Miana M, Martín-Fernández B, de las Heras N, Lahera V. 2006 Obesidad, inflamación y disfunción endotelial. Rev Esp Obes 4, 195-204,

Cannon B, Nedergaard J. 2004 Brown adipose tissue: function and physiological significance. Physiological reviews,

Carbone F, La Rocca C, De Candia P, Procaccini C, Colamatteo A, Micillo T, De Rosa V, Matarese G. Metabolic control of immune tolerance in health and autoimmunity. Seminars in immunology. Pp 491-504. Elsevier, 2016

Cave N, Allan F, Schokkenbroek S, Metekohy C, Pfeiffer D. 2012 A cross-sectional study to compare changes in the prevalence and risk factors for feline obesity between 1993 and 2007 in New Zealand. Preventive veterinary medicine 107, 121-33,

Champion T, Gering A, Zacche E, Ortiz E, Gava F, Brunetto M, Carciofi A, Camacho AA. 2011 Pulmonary function and hemogasometric evaluation of obese and overweight cats. Journal of Veterinary Internal Medicine, 745-,

Chan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D, De Rosa V, Perna F, Fontana S, Mantzoros CS. 2006 Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proceedings of the National Academy of Sciences 103, 8481-6,

Chandalia M, Abate N. 2007 Metabolic complications of obesity: inflated or inflamed? Journal of diabetes and its complications 21, 128-36,

Chandler ML. 2016 Impact of obesity on cardiopulmonary disease. Veterinary Clinics: Small Animal Practice 46, 817-30,

Clarke S, Mellor D, Clements D, Gemmill T, Farrell M, Carmichael S, Bennett D. 2005 Prevalence of radiographic signs of degenerative joint disease in a hospital population of cats. Veterinary Record 157, 793-9,

Colliard L, Ancel J, Benet J-J, Paragon B-M, Blanchard G. 2006 Risk factors for obesity in dogs in France. The Journal of nutrition 136, 1951S-4S,

Colliard L, Paragon B-M, Lemuet B, Bénet J-J, Blanchard G. 2009 Prevalence and risk factors of obesity in an urban population of healthy cats.

Conte C, Fabbrini E, Kars M, Mittendorfer B, Patterson BW, Klein S. 2012 Multiorgan insulin sensitivity in lean and obese subjects. Diabetes care 35, 1316-21,

Corbee RJ. 2013 Obesity in show dogs. Journal of animal physiology and animal nutrition 97, 904-10,

Corbee RJ. Nutrition and the skeletal health of dogs and cats. Utrecht University, 2014a

Corbee RJ. 2014b Obesity in show cats. Journal of animal physiology and animal nutrition 98, 1075-80,

Courcier E, Mellor D, Pendlebury E, Evans C, Yam P. 2012 An investigation into the epidemiology of feline obesity in Great Britain: results of a cross‐sectional study of 47 companion animal practises. Veterinary Record 171, 560-,

Courcier E, Thomson R, Mellor D, Yam P. 2010a An epidemiological study of environmental factors associated with canine obesity. Journal of Small Animal Practice 51, 362-7,

Courcier EA, O'Higgins R, Mellor DJ, Yam PS. 2010b Prevalence and risk factors for feline obesity in a first opinion practice in Glasgow, Scotland. Journal of Feline Medicine and Surgery 12, 746-53,

da Rosa Gomes V, Hernández VGP, Castro LTS, Borges NC, Fioravanti MCS. Veterinary Sciences and Medicine.

Daija N. 2017 Obesity in Dogs and its Impact on Diabetes Mellitus. ANGLISTICUM. Journal of the Association-Institute for English Language and American Studies 6, 50-4,

Dalamaga M, Chou SH, Shields K, Papageorgiou P, Polyzos SA, Mantzoros CS. 2013 Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell metabolism 18, 29-42,

Daminet S, Jeusette I, Duchateau L, Diez M, Van de Maele I, De Rick A. 2003 Evaluation of thyroid function in obese dogs and in dogs undergoing a weight loss protocol. Journal of Veterinary Medicine Series A 50, 213-8,

Dayakar A, Chandrasekaran S, Veronica J, Maurya R. 2016 Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs. Experimental parasitology 160, 54-9,

de Paula RB, da Silva AA, Hall JE. 2004 Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension 43, 41-7,

De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. 2007 A key role of leptin in the control of regulatory T cell proliferation. Immunity 26, 241-55,

Deagle G, Holden SL, Biourge V, Morris PJ, German AJ. 2014 Long-term follow-up after weight management in obese cats. Journal of nutritional science 3,

Deiuliis J, Shah Z, Shah N, Needleman B, Mikami D, Narula V, Perry K, Hazey J, Kampfrath T, Kollengode M. 2011 Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers. PloS one 6, e16376,

Deng J, Liu Y, Yang M, Wang S, Zhang M, Wang X, Ko KH, Hua Z, Sun L, Cao X. 2012 Leptin exacerbates collagen‐induced arthritis via enhancement of Th17 cell response. Arthritis & Rheumatism 64, 3564-73,

Donoghue S, Scarlett JM. 1998 Diet and feline obesity. J Nutr 128, 2776s-8s,

Downes MJ, Devitt C, Downes MT, More SJ. 2017 Understanding the context for pet cat and dog feeding and exercising behaviour among pet owners in Ireland: A qualitative study. Irish veterinary journal 70, 1-10,

Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G. 2012 Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatology international 32, 985-90,

Dulloo AG, Jacquet J, Solinas G, Montani J-P, Schutz Y. 2010 Body composition phenotypes in pathways to obesity and the metabolic syndrome. International journal of obesity 34, S4-S17,

Duval J, Budsberg S, Flo G, Sammarco J. 1999 Breed, sex, and body weight as risk factors for rupture of the cranial cruciate ligament in young dogs. Journal of the American Veterinary Medical Association 215, 811-4,

Edney A, Smith P. 1986 Study of obesity in dogs visiting veterinary practices in the United Kingdom. The Veterinary Record 118, 391-6,

Elmquist JK. 2001 Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiology & behavior 74, 703-8,

Endenburg N, Soontararak S, Charoensuk C, van Lith HA. 2018 Quality of life and owner attitude to dog overweight and obesity in Thailand and the Netherlands. BMC veterinary research 14, 1-19,

Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiéra F, Sharma AM. 2003 The adipose-tissue renin–angiotensin–aldosterone system: role in the metabolic syndrome? The international journal of biochemistry & cell biology 35, 807-25,

Esposito K, Ciotola M, Schisano B, Misso L, Giannetti G, Ceriello A, Giugliano D. 2006 Oxidative stress in the metabolic syndrome. Journal of endocrinological investigation 29, 791-5,

Fain JN. 2010 Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators of inflammation 2010,

Fantuzzi G. 2005 Adipose tissue, adipokines, and inflammation. Journal of Allergy and clinical immunology 115, 911-9,

Fantuzzi G, Faggioni R. 2000 Leptin in the regulation of immunity, inflammation, and hematopoiesis. Journal of leukocyte biology 68, 437-46,

Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S. 2002 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. The Journal of clinical investigation 110, 1093-103,

Ferguson D, Caffall Z, Hoenig M. 2007 Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats. Journal of endocrinology 194, 267-73,

Fernández-Sánchez A, Madrigal-Santillán E, Bautista M, Esquivel-Soto J, Morales-González Á, Esquivel-Chirino C, Durante-Montiel I, Sánchez-Rivera G, Valadez-Vega C, Morales-González JA. 2011 Inflammation, oxidative stress, and obesity. International journal of molecular sciences 12, 3117-32,

Festa A, D’Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM. 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102, 42-7,

Fésüs G, Dubrovska G, Gorzelniak K, Kluge R, Huang Y, Luft FC, Gollasch M. 2007 Adiponectin is a novel humoral vasodilator. Cardiovascular research 75, 719-27,

Fonseca-Alaniz MH, Takada J, Alonso-Vale MIC, Lima FB. 2007 Adipose tissue as an endocrine organ: from theory to practice. Jornal de pediatria 83, S192-S203,

Francisco V, Pino J, Campos-Cabaleiro V, Ruiz-Fernández C, Mera A, Gonzalez-Gay MA, Gómez R, Gualillo O. 2018 Obesity, fat mass and immune system: role for leptin. Frontiers in physiology 9, 640,

Frank L, Mann S, Levine CB, Cummings BP, Wakshlag JJ. 2015 Increasing body condition score is positively associated interleukin-6 and monocyte chemoattractant protein-1 in Labrador retrievers. Veterinary immunology and immunopathology 167, 104-9,

Freeman LM. 2009 The pathophysiology of cardiac cachexia. Current opinion in supportive and palliative care 3, 276-81,

Friedman JM, Halaas JL. 1998 Leptin and the regulation of body weight in mammals. Nature 395, 763-70,

Fritsch D, Allen T, Dodd C, Jewell D, Sixby K, Leventhal P, Hahn K. 2010 Dose‐titration effects of fish oil in osteoarthritic dogs. Journal of Veterinary Internal Medicine 24, 1020-6,

Fruhbeck G, Gómez-Ambrosi J, Muruzábal FJ, Burrell MA. 2001 The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. American Journal of Physiology-Endocrinology and Metabolism 280, E827-E47,

Frye CW, Shmalberg JW, Wakshlag JJ. 2016 Obesity, exercise and orthopedic disease. Veterinary Clinics: Small Animal Practice 46, 831-41,

Galgani M, Procaccini C, De Rosa V, Carbone F, Chieffi P, La Cava A, Matarese G. 2010 Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. The Journal of Immunology 185, 7474-9,

García-Guasch L, Caro-Vadillo A, Manubens-Grau J, Carretón E, Camacho AA, Montoya-Alonso JA. 2015 Pulmonary function in obese vs non-obese cats. Journal of Feline Medicine and Surgery 17, 494-9,

Garcia Guasch L, Caro Vadillo A, Manubens J, Montoya Alonso JA, Camacho A, Molins H. 2013 Effect of obesity on pulmonary function in cats with natural bronchial disease. Journal of Veterinary Internal Medicine,

Gates M, Zito S, Harvey L, Dale A, Walker J. 2019 Assessing obesity in adult dogs and cats presenting for routine vaccination appointments in the North Island of New Zealand using electronic medical records data. New Zealand veterinary journal 67, 126-33,

German A, Holden S, Wiseman-Orr M, Reid J, Nolan A, Biourge V, Morris P, Scott E. 2012 Quality of life is reduced in obese dogs but improves after successful weight loss. The Veterinary Journal 192, 428-34,

German AJ. 2006 The growing problem of obesity in dogs and cats. The Journal of nutrition 136, 1940S-6S,

German AJ, Blackwell E, Evans M, Westgarth C. 2017 Overweight dogs exercise less frequently and for shorter periods: results of a large online survey of dog owners from the UK. Journal of nutritional science 6,

German AJ, Woods GR, Holden SL, Brennan L, Burke C. 2018 Dangerous trends in pet obesity. The Veterinary Record 182, 25,

Glass CK, Olefsky JM. 2012 Inflammation and lipid signaling in the etiology of insulin resistance. Cell metabolism 15, 635-45,

Glickman LT, Schofer FS, McKee LJ, Reif JS, Goldschmidt MH. 1989 Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs. Journal of Toxicology and Environmental Health, Part A Current Issues 28, 407-14,

Goldstein BJ, Scalia R. 2004 Adiponectin: a novel adipokine linking adipocytes and vascular function. The Journal of Clinical Endocrinology & Metabolism 89, 2563-8,

Goossens GH. 2008 The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiology & behavior 94, 206-18,

Gorska E, Popko K, Stelmaszczyk-Emmel A, Ciepiela O, Kucharska A, Wasik M. 2010 Leptin receptors. European journal of medical research 15, 1-5,

Greenberg AS, Obin MS. 2006 Obesity and the role of adipose tissue in inflammation and metabolism. The American journal of clinical nutrition 83, 461S-5S,

Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F. 2010 Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis research & therapy 12, 1-18,

Hajer GR, Van Haeften TW, Visseren FL. 2008 Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. European heart journal 29, 2959-71,

Halliwell B. 1994 Free radicals and antioxidants: a personal view. Nutrition reviews 52, 253-65,

Handl S, Danninger-Dobrovits C, Iben C. 2012 Do feeding instructions on commercial dog foods promote obesity. Proceedings of the European Society of Veterinary and Comparative Nutrition 16, 33,

Handl S, German AJ, Holden SL, Dowd SE, Steiner JM, Heilmann RM, Grant RW, Swanson KS, Suchodolski JS. 2013 Faecal microbiota in lean and obese dogs. FEMS microbiology ecology 84, 332-43,

Häring T, Wichert B, Dolf G, Haase B. 2011 Segregation analysis of overweight body condition in an experimental cat population. Journal of Heredity 102, S28-S31,

Harper E, Stack D, Watson T, Moxham G. 2001 Effects of feeding regimens on bodyweight, composition and condition score in cats following ovariohysterectomy. Journal of Small Animal Practice 42, 433-8,

Harwood Jr HJ. 2012 The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology 63, 57-75,

Heath SE. Behaviour problems and welfare. In. The welfare of cats. Pp 91-118. Springer, 2007

Henegar JR, Bigler SA, Henegar LK, Tyagi SC, Hall JE. 2001 Functional and structural changes in the kidney in the early stages of obesity. Journal of the American Society of Nephrology 12, 1211-7,

Hervera M, Baucells M, Torre C, Buj A, Castrillo C. 2008 Prediction of digestible energy value of extruded dog food: comparison of methods. Journal of animal physiology and animal nutrition 92, 253-9,

Hirata LL, SATO MEO, SANTOS CAdM. 2004 Radicais livres e o envelhecimento cutâneo. Acta Farm. Bonaerense 23, 418-24,

Hoenig M. 2012 The cat as a model for human obesity and diabetes. Journal of diabetes science and technology 6, 525-33,

Hoenig M, McGoldrick J, DeBeer M, Demacker P, Ferguson D. 2006 Activity and tissue-specific expression of lipases and tumor-necrosis factor α in lean and obese cats. Domestic animal endocrinology 30, 333-44,

Hoenig M, Pach N, Thomaseth K, Le A, Schaeffer D, Ferguson DC. 2013 Cats differ from other species in their cytokine and antioxidant enzyme response when developing obesity. Obesity 21, E407-E14,

Hoenig M, Thomaseth K, Waldron M, Ferguson D. 2009 Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss (American Journal of Physiology Regulatory Integrative and Comparative Physiology (2007) 292,(R227-R234) 10.1152/ajpregu. 00313.2006). American Journal of Physiology-Regulatory Integrative and Comparative Physiology 296,

Hoenig M, Wilkins C, Holson JC, Ferguson DC. 2003 Effects of obesity on lipid profiles in neutered male and female cats. American journal of veterinary research 64, 299-303,

Holmes K, Morris P, Abdulla Z, Hackett R, Rawlings J. 2007 Risk factors associated with excess body weight in dogs in the UK. Journal of animal physiology and animal nutrition 91, 166-7,

Holst BS. 2022 Feline breeding and pregnancy management: What is normal and when to intervene. Journal of Feline Medicine and Surgery 24, 221-31,

Holst BS, Gustavsson MH. Animal obesity: causes, consequences and comparative aspects. In. Pp 1-2. (BioMed Central) 2016

Honrado SA. Fatores de risco para o desenvolvimento do excesso de peso e obesidade em cães. Universidade de Lisboa (Portugal), 2018

Honsawek S, Chayanupatkul M. 2010 Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Archives of medical research 41, 593-8,

Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M. 2007 Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901-11,

Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. 1994 Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of clinical investigation 94, 1543-9,

Hotamisligil GS, Shargill NS, Spiegelman BM. 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 87-91,

Howell TJ, Mornement K, Bennett PC. 2016 Pet dog management practices among a representative sample of owners in Victoria, Australia. Journal of Veterinary Behavior 12, 4-12,

Hsu A, Aronoff D, Phipps J, Goel D, Mancuso P. 2007 Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clinical & Experimental Immunology 150, 332-9,

Hu E, Liang P, Spiegelman BM. 1996 AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity (∗). Journal of Biological chemistry 271, 10697-703,

Huang K, Du G, Li L, Liang H, Zhang B. 2012 Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis. Biomarkers 17, 16-20,

Huck JL, Biery DN, Lawler DF, Gregor TP, Runge JJ, Evans RH, Kealy RD, Smith GK. 2009 A longitudinal study of the influence of lifetime food restriction on development of osteoarthritis in the canine elbow. Veterinary surgery 38, 192-8,

Ishioka K, Hosoya K, Kitagawa H, Shibata H, Honjoh T, Kimura K, Saito M. 2007 Plasma leptin concentration in dogs: effects of body condition score, age, gender and breeds. Research in veterinary science 82, 11-5,

Ishioka K, Omachi A, Sasaki N, Kimura K, Saito M. 2009 Feline adiponectin: molecular structures and plasma concentrations in obese cats. Journal of Veterinary Medical Science 71, 189-94,

Ishioka K, Soliman MM, Sagawa M, Nakadomo F, Shibata H, Honjoh T, Hashimoto A, Kitamura H, Kimura K, Saito M. 2002 Experimental and clinical studies on plasma leptin in obese dogs. Journal of Veterinary Medical Science 64, 349-53,

Ivandić A, Prpić-Kriẑevac I, Sučić M, Jurić M. 1998 Hyperinsulinemia and sex hormones in healthy premenopausal women: relative contribution of obesity, obesity type, and duration of obesity. Metabolism 47, 13-9,

J Neff K, O'Shea D, W le Roux C. 2013 Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: a Signpost to a new frontier. Current diabetes reviews 9, 93-101,

Jahn J, Spielau M, Brandsch C, Stangl GI, Delank KS, Bähr I, Berreis T, Wrann CD, Kielstein H. 2015 Decreased NK cell functions in obesity can be reactivated by fat mass reduction. Obesity 23, 2233-41,

Jeusette I, Detilleux J, Cuvelier C, Istasse L, Diez M. 2004 Ad libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites. Journal of animal physiology and animal nutrition 88, 117-21,

Jeusette I, Greco D, Aquino F, Detilleux J, Peterson M, Romano V, Torre C. 2010 Effect of breed on body composition and comparison between various methods to estimate body composition in dogs. Research in veterinary science 88, 227-32,

Jeusette IC, Detilleux J, Shibata H, Saito M, Honjoh T, Delobel A, Istasse L, Diez M. 2005a Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Research in veterinary science 79, 169-75,

Jeusette IC, Lhoest ET, Istasse LP, Diez MO. 2005b Influence of obesity on plasma lipid and lipoprotein concentrations in dogs. American journal of veterinary research 66, 81-6,

Johnson KA, Lee AH, Swanson KS. 2020 Nutrition and nutraceuticals in the changing management of osteoarthritis for dogs and cats. Journal of the American Veterinary Medical Association 256, 1335-41,

Johnston SA. 1997 Osteoarthritis: joint anatomy, physiology, and pathobiology. Veterinary Clinics of North America: Small Animal Practice 27, 699-723,

Jordan E, Kley S, Le N-A, Waldron M, Hoenig M. 2008 Dyslipidemia in obese cats. Domestic animal endocrinology 35, 290-9,

Juge-Aubry CE, Henrichot E, Meier CA. 2005 Adipose tissue: a regulator of inflammation. Best practice & research Clinical endocrinology & metabolism 19, 547-66,

Jung CH, Kim M-S. 2013 Molecular mechanisms of central leptin resistance in obesity. Archives of pharmacal research 36, 201-7,

Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP. 1993 Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42, 1663-72,

Kasuga M. 2006 Insulin resistance and pancreatic β cell failure. The Journal of clinical investigation 116, 1756-60,

Katona P, Katona-Apte J. 2008 The interaction between nutrition and infection. Clinical Infectious Diseases 46, 1582-8,

Kawauchi IM, Jeremias JT, Takeara P, de Souza DF, de Carvalho Balieiro JC, Pfrimer K, Brunetto MA, Pontieri CFF. 2017 Effect of dietary protein intake on the body composition and metabolic parameters of neutered dogs. Journal of nutritional science 6,

Kealy R, Lawler D, Ballam J, Lust G, Smith G, Biery D, Olsson S. 1997 Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. Journal of the American Veterinary Medical Association 210, 222-5,

Kealy RD, Lawler DF, Ballam JM, Lust G, Biery DN, Smith GK, Mantz SL. 2000 Evaluation of the effect of limited food consumption on radiographic evidence of osteoarthritis in dogs. Journal of the American Veterinary Medical Association 217, 1678-80,

Kienzle E, Bergler R. 2006 Human-animal relationship of owners of normal and overweight cats. The Journal of nutrition 136, 1947S-50S,

Kienzle E, Bergler R, Mandernach A. 1998 A comparison of the feeding behavior and the human–animal relationship in owners of normal and obese dogs. The Journal of nutrition 128, 2779S-82S,

Kley S, Hoenig M, Glushka J, Jin ES, Burgess SC, Waldron M, Jordan ET, Prestegard JH, Ferguson DC, Wu S. 2009 The impact of obesity, sex, and diet on hepatic glucose production in cats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, R936-R43,

KOCABAĞLI N, Müjdat A, Bülent E, Kutay HC, Keser O, Dokuzeylül B. 2019 The evaluation of prevalence and risk factors of overweight and obesity in cats from some private veterinary clinics in Istanbul, Turkey. Journal of Istanbul Veterinary Sciences, 35-,

Kohchi C, Inagawa H, Nishizawa T, Soma G-I. 2009 ROS and innate immunity. Anticancer research 29, 817-21,

Kota SK, Kota SK, Jammula S, Krishna S, Modi KD. 2012 Hypertriglyceridemia-induced recurrent acute pancreatitis: A case-based review. Indian journal of endocrinology and metabolism 16, 141,

Kour H, Agrawal R, Singh R, Pande N. 2019 Prevalence and risk factors for obesity in dogs. J. Pharm. Innov 8, 709-13,

Kumar P, Bhattacharya P, Prabhakar BS. 2018 A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity. Journal of autoimmunity 95, 77-99,

Kutsunai M, Kanemoto H, Fukushima K, Fujino Y, Ohno K, Tsujimoto H. 2014 The association between gall bladder mucoceles and hyperlipidaemia in dogs: a retrospective case control study. The Veterinary Journal 199, 76-9,

Kyrou I, Tsigos C. 2008 Chronic stress, visceral obesity and gonadal dysfunction. Hormones 7, 287-93,

La Cava A. 2004 Matarese G. The weight of leptin in immunity. Nat Rev Immunol 4, 371-9,

La Cava A. 2017 Leptin in inflammation and autoimmunity. Cytokine 98, 51-8,

La Cava A, Alviggi C, Matarese G. 2004 Unraveling the multiple roles of leptin in inflammation and autoimmunity. Journal of molecular medicine 82, 4-11,

Laflamme D. 2012 Nutritional care for aging cats and dogs. Veterinary Clinics: Small Animal Practice 42, 769-91,

Laflamme DP. 2005 Nutrition for aging cats and dogs and the importance of body condition. Veterinary Clinics: Small Animal Practice 35, 713-42,

Lafontan M. 2005 Fat cells: afferent and efferent messages define new approaches to treat obesity. Annual review of pharmacology and toxicology 45, 119-46,

Lago F, Dieguez C, Gómez-Reino J, Gualillo O. 2007 Adipokines as emerging mediators of immune response and inflammation. Nature clinical practice Rheumatology 3, 716-24,

Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino J, Gualillo O. 2008 A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis and Cartilage 16, 1101-9,

Lam Q, Lu L. 2007 Role of leptin in immunity. Cell Mol Immunol 4, 1-13,

Lam QLK, Liu S, Cao X, Lu L. 2006 Involvement of leptin signaling in the survival and maturation of bone marrow‐derived dendritic cells. European journal of immunology 36, 3118-30,

Lam QLK, Wang S, Ko OKH, Kincade PW, Lu L. 2010 Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1. Proceedings of the National Academy of Sciences 107, 13812-7,

Laplante M, Sabatini DM. 2012 mTOR signaling. Cold Spring Harbor perspectives in biology 4, a011593,

Larsen JA. 2017 Risk of obesity in the neutered cat. Journal of Feline Medicine and Surgery 19, 779-83,

Larsen JA, Villaverde C. 2016 Scope of the problem and perception by owners and veterinarians. Veterinary Clinics: Small Animal Practice 46, 761-72,

Larson BT, Lawler DF, Spitznagel Jr EL, Kealy RD. 2003 Improved glucose tolerance with lifetime diet restriction favorably affects disease and survival in dogs. The Journal of nutrition 133, 2887-92,

Lascelles BDX, Henry III JB, Brown J, Robertson I, Sumrell AT, Simpson W, Wheeler S, Hansen BD, Zamprogno H, Freire M. 2010 Cross‐sectional study of the prevalence of radiographic degenerative joint disease in domesticated cats. Veterinary surgery 39, 535-44,

Lastra G, Manrique CM, Hayden MR. 2006 The Role of β‐Cell Dysfunction in the Cardiometabolic Syndrome. Journal of the cardiometabolic syndrome 1, 41-6,

Laue T, Wrann CD, Hoffmann-Castendiek B, Pietsch D, Hübner L, Kielstein H. 2015 Altered NK cell function in obese healthy humans. BMC obesity 2, 1-10,

Lawler DF, Evans RH, Larson BT, Spitznagel EL, Ellersieck MR, Kealy RD. 2005 Influence of lifetime food restriction on causes, time, and predictors of death in dogs. Journal of the American Veterinary Medical Association 226, 225-31,

Lawler DF, Larson BT, Ballam JM, Smith GK, Biery DN, Evans RH, Greeley EH, Segre M, Stowe HD, Kealy RD. 2008 Diet restriction and ageing in the dog: major observations over two decades. British journal of nutrition 99, 793-805,

Lee B-C, Lee J. 2014 Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842, 446-62,

Lee Y-H, Pratley RE. 2005 The evolving role of inflammation in obesity and the metabolic syndrome. Current diabetes reports 5, 70-5,

Leto D, Saltiel AR. 2012 Regulation of glucose transport by insulin: traffic control of GLUT4. Nature reviews Molecular cell biology 13, 383-96,

Lim H-Y, Im K-S, Kim N-H, Kim H-W, Shin J-I, Yhee J-Y, Sur J-H. 2015a Effects of obesity and obesity-related molecules on canine mammary gland tumors. Veterinary pathology 52, 1045-51,

Lim H, Im K, Kim N, Kim H, Shin J, Sur J. 2015b Obesity, expression of adipocytokines, and macrophage infiltration in canine mammary tumors. The Veterinary Journal 203, 326-31,

Lin CK, Lin CC. 2012 Work of breathing and respiratory drive in obesity. Respirology 17, 402-11,

Linder DE, Santiago S, Halbreich ED. 2021 Is there a correlation between dog obesity and human obesity? preliminary findings of overweight status among dog owners and their dogs. Frontiers in Veterinary Science, 736,

Loftus JP, Wakshlag JJ. 2015 Canine and feline obesity: a review of pathophysiology, epidemiology, and clinical management. Vet Med (Auckl) 6, 49-60,

Loyd C, Obici S. 2014 Brown fat fuel use and regulation of energy homeostasis. Current Opinion in Clinical Nutrition & Metabolic Care 17, 368-72,

Lucena S, Lamy E, Capela F, Lavrador C, Tvarijonaviciute A. 2018 Human and canine prevalence obesity and feending habits–a one health approach in Portugal.

Lund EM, Armstrong P, Kirk CA, Klausner J. 2005 Prevalence and risk factors for obesity in adult cats from private US veterinary practices. Intern J Appl Res Vet Med 3, 88-96,

Lund EM, Armstrong PJ, Kirk CA, Klausner JS. 2006 Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. International Journal of Applied Research in Veterinary Medicine 4, 177,

Lund HS, Sævik BK, Finstad ØW, Grøntvedt ET, Vatne T, Eggertsdóttir AV. 2016 Risk factors for idiopathic cystitis in Norwegian cats: a matched case-control study. Journal of Feline Medicine and Surgery 18, 483-91,

Madan R, Guo X, Naylor C, Buonomo EL, Mackay D, Noor Z, Concannon P, Scully KW, Pramoonjago P, Kolling GL. 2014 Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infection and immunity 82, 341-9,

Maldonado-Ruiz R, Fuentes-Mera L, Camacho A. 2017 Central modulation of neuroinflammation by neuropeptides and energy-sensing hormones during obesity. BioMed research international 2017,

Manens J, Bolognin M, Bernaerts F, Diez M, Kirschvink N, Clercx C. 2012 Effects of obesity on lung function and airway reactivity in healthy dogs. The Veterinary Journal 193, 217-21,

Manens J, Ricci R, Damoiseaux C, Gault S, Contiero B, Diez M, Clercx C. 2014 Effect of body weight loss on cardiopulmonary function assessed by 6‐minute walk test and arterial blood gas analysis in obese dogs. Journal of Veterinary Internal Medicine 28, 371-8,

Mao J, Xia Z, Chen J, Yu J. 2013 Prevalence and risk factors for canine obesity surveyed in veterinary practices in Beijing, China. Preventive veterinary medicine 112, 438-42,

Margetic S, Gazzola C, Pegg G, Hill R. 2002 Leptin: a review of its peripheral actions and interactions. International journal of obesity 26, 1407-33,

Marino AB, Cole SW, Nuzum DS. 2014 Alternative dosing strategies for liraglutide in patients with type 2 diabetes mellitus. American journal of health-system pharmacy 71, 223-6,

Marshall W, Bockstahler B, Hulse D, Carmichael S. 2009 A review of osteoarthritis and obesity: current understanding of the relationship and benefit of obesity treatment and prevention in the dog. Veterinary and Comparative Orthopaedics and Traumatology 22, 339-45,

Martín-Romero C, Santos-Alvarez J, Goberna R, Sánchez-Margalet V. 2000 Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cellular immunology 199, 15-24,

Martin LJ, Siliart B, Dumon HJ, Nguyen P. 2006 Spontaneous hormonal variations in male cats following gonadectomy. Journal of Feline Medicine and Surgery 8, 309-14,

Maruyoshi H, Kojima S, Funahashi T, Miyamoto S, Hokamaki J, Soejima H, Sakamoto T, Kawano H, Yoshimura M, Kitagawa A. 2004 Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina. Thrombosis and haemostasis 91, 1026-30,

Mason B, Wang Q, Zigman J. 2014 The central nervous system sites mediating the orexigenic actions of ghrelin. Annual review of physiology 76, 519,

Matarese G, La Cava A. 2004 The intricate interface between immune system and metabolism. Trends in immunology 25, 193-200,

Mattheeuws D. 1984 Glucose tolerance and insulin response in obese dogs. JAAHA 20, 283-93,

Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M. 2005 Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. The Journal of Immunology 174, 6820-8,

Maury E, Brichard S. 2010 Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Molecular and cellular endocrinology 314, 1-16,

Maurya R, Bhattacharya P, Dey R, Nakhasi HL. 2018 Leptin functions in infectious diseases. Frontiers in immunology 9, 2741,

McGreevy P, Thomson P, Pride C, Fawcett A, Grassi T, Jones B. 2005 Prevalence of obesity in dogs examined by Australian veterinary practices and the risk factors involved. Veterinary Record 156, 695-702,

McGreevy P, Thomson P, Pride C, Fawcett A, Grassi T, Jones B. 2008 Overweight or obese cats presented to Australian veterinary practices, risk factors and prevalence. Australian Veterinary Practitioner 38, 98-+,

McLeod LE, Proud CG. 2002 ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. FEBS letters 531, 448-52,

McMillan FD. 2013 Stress-induced and emotional eating in animals: a review of the experimental evidence and implications for companion animal obesity. Journal of Veterinary Behavior 8, 376-85,

Medina G, Vera-Lastra O, Peralta-Amaro AL, Jiménez-Arellano MP, Saavedra MA, Cruz-Domínguez MP, Jara LJ. 2018 Metabolic syndrome, autoimmunity and rheumatic diseases. Pharmacological research 133, 277-88,

Mehlman E, Bright J, Jeckel K, Porsche C, Veeramachaneni D, Frye M. 2013 Echocardiographic evidence of left ventricular hypertrophy in obese dogs. Journal of Veterinary Internal Medicine 27, 62-8,

Mellema M. Non-respiratory co-morbidity of brachycephalic patients. Proc International Veterinary Emergency and Critical Care Symposium, 2012

Menchetti L, Calipari S, Guelfi G, Catanzaro A, Diverio S. 2018 My dog is not my cat: Owner perception of the personalities of dogs and cats living in the same household. Animals 8, 80,

Michel KE, Sorenmo K, Shofer FS. 2004 Evaluation of body condition and weight loss in dogs presented to a veterinary oncology service. Journal of Veterinary Internal Medicine 18, 692-5,

Mittendorfer B, Magkos F, Fabbrini E, Mohammed BS, Klein S. 2009 Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity 17, 1872-7,

Moller DE. 2000 Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes. Trends in Endocrinology & Metabolism 11, 212-7,

Montoya-Alonso JA, Bautista-Castaño I, Peña C, Suárez L, Juste MC, Tvarijonaviciute A. 2017a Prevalence of canine obesity, obesity-related metabolic dysfunction, and relationship with owner obesity in an obesogenic region of Spain. Frontiers in Veterinary Science 4, 59,

Montoya-Alonso JA, Bautista-Castaño I, Peña C, Suárez L, Juste MC, Tvarijonaviciute A. 2017b Prevalence of Canine Obesity, Obesity-Related Metabolic Dysfunction, and Relationship with Owner Obesity in an Obesogenic Region of Spain. Front Vet Sci 4, 59,

Morales MS, Mueller D. 2018 Anergy into T regulatory cells: an integration of metabolic cues and epigenetic changes at the Foxp3 conserved non-coding sequence 2. F1000Research 7,

Mori N, Okada Y, Tsuchida N, Hatano Y, Habara M, Ishikawa S, Yamamoto I, Arai T. 2015 Preliminary analysis of modified low-density lipoproteins in the serum of healthy and obese dogs and cats. Frontiers in Veterinary Science, 34,

Morrison R, Penpraze V, Beber A, Reilly J, Yam P. 2013 Associations between obesity and physical activity in dogs: a preliminary investigation. Journal of Small Animal Practice 54, 570-4,

Morton GJ, Schwartz MW. 2011 Leptin and the central nervous system control of glucose metabolism. Physiological reviews 91, 389-411,

Mounika A, Prasad VD, Sreenu M. 2020 Prevalence and Signalment of Obesity in Canines-A Clinical Study. Intas Polivet 21,

Muñoz-Prieto A, Nielsen LR, Dąbrowski R, Bjørnvad CR, Söder J, Lamy E, Monkeviciene I, Ljubić BB, Vasiu I, Savic S. 2018 European dog owner perceptions of obesity and factors associated with human and canine obesity. Scientific reports 8, 1-10,

Muoio DM, Newgard CB. 2008 Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nature reviews Molecular cell biology 9, 193-205,

Murab S, Chameettachal S, Bhattacharjee M, Das S, Kaplan DL, Ghosh S. 2013 Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments. Tissue Engineering Part A 19, 1733-53,

Muranaka S, Mori N, Hatano Y, Saito T, Lee P, Kojima M, Kigure M, Yagishita M, Arai T. 2011 Obesity induced changes to plasma adiponectin concentration and cholesterol lipoprotein composition profile in cats. Research in veterinary science 91, 358-61,

Murugan A, Sharma G. 2008 Obesity and respiratory diseases. Chronic respiratory disease 5, 233-42,

Myers Jr MG, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. 2012 Challenges and opportunities of defining clinical leptin resistance. Cell metabolism 15, 150-6,

Najib S, Sánchez-Margalet Vc. 2002 Human leptin promotes survival of human circulating blood monocytes prone to apoptosis by activation of p42/44 MAPK pathway. Cellular immunology 220, 143-9,

Nandini M, Kamran CA, Yathiraj S, Upendra H, Kumar VG, Rao S. 2012 Hematological, biochemical and lipid profile changes associated with obesity in dogs. Indian Veterinary Journal 89, 79-81,

Nannipieri M, Baldi S, Mari A, Colligiani D, Guarino D, Camastra S, Barsotti E, Berta R, Moriconi D, Bellini R. 2013 Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones. The Journal of Clinical Endocrinology & Metabolism 98, 4391-9,

Nicoll R, Jackson M, Knipp B, Zagzebski J, Steinberg H, O'Brien R. 1998 Quantitative ultrasonography of the liver in cats during obesity induction and dietary restriction. Research in veterinary science 64, 1-6,

Öhlund M, Palmgren M, Holst BS. 2018 Overweight in adult cats: a cross-sectional study. Acta Veterinaria Scandinavica 60, 1-10,

Olin SJ, Bartges JW. 2015 Urinary tract infections: treatment/comparative therapeutics. Veterinary Clinics: Small Animal Practice 45, 721-46,

Ouchi N, Ohashi K, Shibata R, Murohara T. 2012 Adipocytokines and obesity-linked disorders. Nagoya journal of medical science 74, 19,

Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, Kumada M, Ohashi K, Okamoto Y, Nishizawa H. 2003 Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42, 231-4,

Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K, Chan L, Goldstein BJ, Scalia R. 2007 Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. The Journal of clinical investigation 117, 1718-26,

Palatucci AT, Piantedosi D, Rubino V, Giovazzino A, Guccione J, Pernice V, Ruggiero G, Cortese L, Terrazzano G. 2018 Circulating regulatory T cells (Treg), leptin and induction of proinflammatory activity in obese Labrador Retriever dogs. Veterinary immunology and immunopathology 202, 122-9,

Pan W, Kastin AJ. 2007 Adipokines and the blood-brain barrier. Peptides 28, 1317-30,

Parameswaran K, Todd DC, Soth M. 2006 Altered respiratory physiology in obesity. Canadian respiratory journal 13, 203-10,

Park H-J, Lee S-E, Oh J-H, Seo K-W, Song K-H. 2014 Leptin, adiponectin and serotonin levels in lean and obese dogs. BMC veterinary research 10, 1-8,

Park HJ, Lee SE, Kim HB, Isaacson R, Seo KW, Song KH. 2015 Association of obesity with serum leptin, adiponectin, and serotonin and gut microflora in beagle dogs. Journal of Veterinary Internal Medicine 29, 43-50,

Park HS, Park JY, Yu R. 2005 Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes research and clinical practice 69, 29-35,

Pasquali R, Patton L, Gambineri A. 2007 Obesity and infertility. Current Opinion in Endocrinology, Diabetes and Obesity 14, 482-7,

Pelosi A, Rosenstein D, Abood S, Olivier B. 2013 Cardiac effect of short‐term experimental weight gain and loss in dogs. Veterinary Record 172, 153-,

Pena C, Suárez L, Bautista I, Montoya J, Juste M. 2008 Relationship between analytic values and canine obesity. Journal of animal physiology and animal nutrition 92, 324-5,

Pereira‐Neto GB, Brunetto MA, Oba PM, Champion T, Villaverde C, Vendramini TH, Balieiro JC, Carciofi AC, Camacho AA. 2018 Weight loss improves arterial blood gases and respiratory parameters in obese dogs. Journal of animal physiology and animal nutrition 102, 1743-8,

Pérez-Pérez A, Vilariño-García T, Fernández-Riejos P, Martín-González J, Segura-Egea JJ, Sánchez-Margalet V. 2017 Role of leptin as a link between metabolism and the immune system. Cytokine & growth factor reviews 35, 71-84,

Philibert JC, Snyder PW, Glickman N, Glickman LT, Knapp DW, Waters DJ. 2003 Influence of host factors on survival in dogs with malignant mammary gland tumors. Journal of Veterinary Internal Medicine 17, 102-6,

Piantedosi D, Di Loria A, Guccione J, De Rosa A, Fabbri S, Cortese L, Carta S, Ciaramella P. 2016 Serum biochemistry profile, inflammatory cytokines, adipokines and cardiovascular findings in obese dogs. The Veterinary Journal 216, 72-8,

Pilz S, März W. 2008 Free fatty acids as a cardiovascular risk factor. Clinical chemistry and laboratory medicine 46, 429-34,

Pond CM. 2011 Ecology of storage and allocation of resources: animals. eLS,

Porsani MYH, Teixeira FA, Oliveira VV, Pedrinelli V, Dias RA, German AJ, Brunetto MA. 2020 Prevalence of canine obesity in the city of São Paulo, Brazil. Scientific reports 10, 1-15,

Preet GS, Turkar S, Gupta S, Kumar S. 2021 Dog obesity: Epidemiology, risk factors, diagnosis and management: A review paper. J. Pharm. Innov 10, 698-705,

Price AK, De Godoy M, Harper T, Knap K, Joslyn S, Pietrzkowski Z, Cross B, Detweiler K, Swanson K. 2017 Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis. Journal of animal science 95, 2907-16,

Procaccini C, Carbone F, Galgani M, La Rocca C, De Rosa V, Cassano S, Matarese G. 2011 Obesity and susceptibility to autoimmune diseases. Expert Review of Clinical Immunology 7, 287-94,

Procaccini C, Jirillo E, Matarese G. 2012 Leptin as an immunomodulator. Molecular aspects of medicine 33, 35-45,

Pusoonthornthum R, Pusoonthornthum P, Osborne CA. 2012 Risk factors for feline lower urinary tract diseases in Thailand. The Thai Journal of Veterinary Medicine 42, 517,

Radin MJ, Sharkey LC, Holycross BJ. 2009 Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses. Veterinary clinical pathology 38, 136-56,

Raffan E, Smith SP, O’Rahilly S, Wardle J. 2015 Development, factor structure and application of the Dog Obesity Risk and Appetite (DORA) questionnaire. PeerJ 3, e1278,

Ramón JM, Salvans S, Crous X, Puig S, Goday A, Benaiges D, Trillo L, Pera M, Grande L. 2012 Effect of Roux-en-Y gastric bypass vs sleeve gastrectomy on glucose and gut hormones: a prospective randomised trial. Journal of Gastrointestinal Surgery 16, 1116-22,

Ray R, Shah AM. 2005 NADPH oxidase and endothelial cell function. Clinical Science 109, 217-26,

Reis BS, Lee K, Fanok MH, Mascaraque C, Amoury M, Cohn LB, Rogoz A, Dallner OS, Moraes-Vieira PM, Domingos AI. 2015 Leptin receptor signaling in T cells is required for Th17 differentiation. The Journal of Immunology 194, 5253-60,

Reseland JE, Anderssen SA, Solvoll K, Hjermann I, Urdal P, Holme I, Drevon CA. 2001 Effect of long-term changes in diet and exercise on plasma leptin concentrations. The American journal of clinical nutrition 73, 240-5,

Ricci R, Bevilacqua F. 2012 The potential role of leptin and adiponectin in obesity: a comparative review. The Veterinary Journal 191, 292-8,

Richter M, Trzeciak T, Owecki M, Pucher A, Kaczmarczyk J. 2015 The role of adipocytokines in the pathogenesis of knee joint osteoarthritis. International orthopaedics 39, 1211-7,

Robertson I. 1999 The influence of diet and other factors on owner-perceived obesity in privately owned cats from metropolitan Perth, Western Australia. Preventive veterinary medicine 40, 75-85,

Robertson I. 2003 The association of exercise, diet and other factors with owner-perceived obesity in privately owned dogs from metropolitan Perth, WA. Preventive veterinary medicine 58, 75-83,

Rocchini AP, Yang JQ, Gokee A. 2004 Hypertension and insulin resistance are not directly related in obese dogs. Hypertension 43, 1011-6,

Rodríguez L, Graniel J, Ortiz R. 2007 Effect of leptin on activation and cytokine synthesis in peripheral blood lymphocytes of malnourished infected children. Clinical & Experimental Immunology 148, 478-85,

Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D, White T, Spiegelman BM. 1989 Adipsin and complement factor D activity: an immune-related defect in obesity. Science 244, 1483-7,

Rosen ED, Spiegelman BM. 2006 Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444, 847-53,

Roush JK, Dodd CE, Fritsch DA, Allen TA, Jewell DE, Schoenherr WD, Richardson DC, Leventhal PS, Hahn KA. 2010 Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. Journal of the American Veterinary Medical Association 236, 59-66,

Rowan A, Rowan A, Quain A, Quain A, Quain A, Bain M, Kipperman B, Dürnberger C, Grimm H, Kipperman B. 2022 11Access to Veterinary Care: A National Family Crisis. Ethics in Veterinary Practice: Balancing Conflicting Interests, 189-226,

Rowe E, Browne W, Casey R, Gruffydd-Jones T, Murray J. 2015a Risk factors identified for owner-reported feline obesity at around one year of age: Dry diet and indoor lifestyle. Prev Vet Med 121, 273-81,

Rowe E, Browne W, Casey R, Gruffydd-Jones T, Murray J. 2015b Risk factors identified for owner-reported feline obesity at around one year of age: Dry diet and indoor lifestyle. Preventive veterinary medicine 121, 273-81,

Rowe E, Browne W, Casey R, Gruffydd-Jones T, Murray J. 2017 Early-life risk factors identified for owner-reported feline overweight and obesity at around two years of age. Preventive veterinary medicine 143, 39-48,

Runge JJ, Biery DN, Lawler DF, Gregor TP, Evans RH, Kealy RD, Szabo SD, Smith GK. 2008 The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder. Veterinary surgery 37, 102-7,

Russell K, Sabin R, Holt S, Bradley R, Harper E. 2000 Influence of feeding regimen on body condition in the cat. Journal of Small Animal Practice 41, 12-8,

Sagawa MM, Nakadomo F, Honjoh T, Ishioka K, Saito M. 2002 Correlation between plasma leptin concentration and body fat content in dogs. American journal of veterinary research 63, 7-10,

Sakaguchi S. 2003 The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. The Journal of clinical investigation 112, 1310-2,

Sallander M, Hagberg M, Hedhammar Å, Rundgren M, Lindberg JE. 2010 Energy-intake and activity risk factors for owner-perceived obesity in a defined population of Swedish dogs. Preventive veterinary medicine 96, 132-41,

Saltiel AR, Kahn CR. 2001 Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806,

Sanchez-Margalet V, Martin-Romero C, Gonzalez-Yanes C, Goberna R, Rodriguez-Bano J, Muniain M. 2002 Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clinical & Experimental Immunology 129, 119-24,

Sánchez-Muñoz F, García-Macedo R, Alarcón-Aguilar F, Cruz M. 2005 Adipocinas, tejido adiposo y su relación con células del sistema inmune. Gaceta médica de México 141, 505-12,

Sánchez-Pozo C, Rodriguez-Bano J, Dominguez-Castellano A, Muniain M, Goberna R, Sánchez-Margalet V. 2003 Leptin stimulates the oxidative burst in control monocytes but attenuates the oxidative burst in monocytes from HIV-infected patients. Clinical & Experimental Immunology 134, 464-9,

Sandøe P, Palmer C, Corr S, Astrup A, Bjørnvad CR. 2014 Canine and feline obesity: a One Health perspective. Veterinary Record 175, 610-6,

Sandoval DA, Davis SN. 2003 Leptin: metabolic control and regulation. Journal of diabetes and its complications 17, 108-13,

Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. 1995 A novel serum protein similar to C1q, produced exclusively in adipocytes. Journal of Biological chemistry 270, 26746-9,

Schneeberger M, Gomis R, Claret M. 2014 Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. Journal of endocrinology 220, T25-T46,

Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte Jr D. 1992 Insulin in the brain: a hormonal regulator of energy balance. Endocrine reviews 13, 387-414,

Sebastian JC. 2013 Respiratory physiology and pulmonary complications in obesity. Best practice & research Clinical endocrinology & metabolism 27, 157-61,

Segev G, Livne H, Ranen E, Lavy E. 2011 Urethral obstruction in cats: predisposing factors, clinical, clinicopathological characteristics and prognosis. Journal of Feline Medicine and Surgery 13, 101-8,

Seguin MA, Vaden SL, Altier C, Stone E, Levine JF. 2003 Persistent urinary tract infections and reinfections in 100 dogs (1989–1999). Journal of Veterinary Internal Medicine 17, 622-31,

Serisier S, Weber M, Feugier A, Fardet MO, Garnier F, Biourge V, German A. 2013 Maintenance energy requirements in miniature colony dogs. Journal of animal physiology and animal nutrition 97, 60-7,

Servet E, Biourge V, Marniquet P. 2006 Dietary intervention can improve clinical signs in osteoarthritic dogs. The Journal of nutrition 136, 1995S-7S,

Shibata R, Izumiya Y, Sato K, Papanicolaou K, Kihara S, Colucci WS, Sam F, Ouchi N, Walsh K. 2007 Adiponectin protects against the development of systolic dysfunction following myocardial infarction. Journal of molecular and cellular cardiology 42, 1065-74,

Shimomura I, Funahasm T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K. 1996 Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty. Nature medicine 2, 800-3,

Shivahare R, Ali W, Vishwakarma P, Natu S, Puri SK, Gupta S. 2015 Leptin augments protective immune responses in murine macrophages and enhances potential of miltefosine against experimental visceral leishmaniasis. Acta tropica 150, 35-41,

Simopoulou T, Malizos K, Iliopoulos D, Stefanou N, Papatheodorou L, Ioannou M, Tsezou A. 2007 Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism. Osteoarthritis and Cartilage 15, 872-83,

Singla P, Bardoloi A, Parkash AA. 2010 Metabolic effects of obesity: a review. World journal of diabetes 1, 76,

Smith GK, Mayhew PD, Kapatkin AS, McKelvie PJ, Shofer FS, Gregor TP. 2001 Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German Shepherd Dogs, Golden Retrievers, Labrador Retrievers, and Rottweilers. Journal of the American Veterinary Medical Association 219, 1719-24,

Sonnenschein EG, Glickman LT, Goldschmidt MH, McKee LJ. 1991 Body conformation, diet, and risk of breast cancer in pet dogs: a case-control study. American journal of epidemiology 133, 694-703,

Speakman JR. 2004 Obesity: the integrated roles of environment and genetics. The Journal of nutrition 134, 2090S-105S,

Speakman JR, Levitsky DA, Allison DB, Bray MS, De Castro JM, Clegg DJ, Clapham JC, Dulloo AG, Gruer L, Haw S. 2011 Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Disease models & mechanisms 4, 733-45,

Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. 2001 The hormone resistin links obesity to diabetes. Nature 409, 307-12,

Stone R, Berghoff N, Steiner J, Zoran D. 2009 Use of a bioelectric impedance device in obese and lean healthy dogs to estimate body fat percentage. Veterinary therapeutics: research in applied veterinary medicine 10, 59-70,

Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F, Häring H. 2002 Association of the TG polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51, 37-41,

Suarez L, Bautista-Castaño I, Peña Romera C, Montoya-Alonso JA, Corbera JA. 2022 Is Dog Owner Obesity a Risk Factor for Canine Obesity? A “One-Health” Study on Human–Animal Interaction in a Region with a High Prevalence of Obesity. Veterinary sciences 9, 243,

Suarez L, Peña C, Carretón E, Juste M, Bautista‐Castaño I, Montoya‐Alonso JA. 2012 Preferences of owners of overweight dogs when buying commercial pet food. Journal of animal physiology and animal nutrition 96, 655-9,

Suokas A, Walsh D, McWilliams D, Condon L, Moreton B, Wylde V, Arendt-Nielsen L, Zhang W. 2012 Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis and Cartilage 20, 1075-85,

Suzuki K, Simpson KA, Minnion JS, Shillito JC, Bloom SR. 2010 The role of gut hormones and the hypothalamus in appetite regulation. Endocrine journal 57, 359-72,

Taguchi A, Wartschow LM, White MF. 2007 Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317, 369-72,

Takeda T, Sakata M, Isobe A, Miyake A, Nishimoto F, Ota Y, Kamiura S, Kimura T. 2008 Relationship between metabolic syndrome and uterine leiomyomas: a case-control study. Gynecologic and obstetric investigation 66, 14-7,

Tarkosova D, Story M, Rand J, Svoboda M. 2016 Feline obesity–prevalence, risk factors, pathogenesis, associated conditions and assessment: a review. Veterinární medicína 61, 295-307,

Teng K, McGreevy P, Toribio J, Raubenheimer D, Kendall K, Dhand N. 2018 Associations of body condition score with health conditions related to overweight and obesity in cats. Journal of Small Animal Practice 59, 603-15,

Teng KT, McGreevy PD, Toribio J-AL, Dhand NK. 2020 Positive attitudes towards feline obesity are strongly associated with ownership of obese cats. PloS one 15, e0234190,

Teng KT, McGreevy PD, Toribio J-AL, Raubenheimer D, Kendall K, Dhand NK. 2017 Risk factors for underweight and overweight in cats in metropolitan Sydney, Australia. Preventive veterinary medicine 144, 102-11,

Thengchaisri N, Theerapun W, Kaewmokul S, Sastravaha A. 2014 Abdominal obesity is associated with heart disease in dogs. BMC veterinary research 10, 1-7,

Thethi T, Kamiyama M, Kobori H. 2012 The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome. Current hypertension reports 14, 160-9,

Thijssen E, Van Caam A, Van Der Kraan PM. 2015 Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis. Rheumatology 54, 588-600,

Tremmel M, Gerdtham U-G, Nilsson PM, Saha S. 2017 Economic burden of obesity: a systematic literature review. International journal of environmental research and public health 14, 435,

Tribuddharatana T, Kongpiromchean Y, Sribhen K, Sribhen C. 2011 Biochemical alterations and their relationships with the metabolic syndrome components in canine obesity. Agriculture and Natural Resources 45, 622-8,

Truett AA, Borne AT, Monteiro MP, West DB. 1998 Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog. Obesity research 6, 137-46,

Truett AA, Borne AT, Poincot MA, West DB. 1996 Autonomic control of blood pressure and heart rate in obese hypertensive dogs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 270, R541-R9,

Turer A, Scherer P. 2012 Adiponectin: mechanistic insights and clinical implications. Diabetologia 55, 2319-26,

Tvarijonaviciute A, Ceron J, Holden S, Morris P, Biourge V, German A. 2012a Effects of weight loss in obese cats on biochemical analytes related to inflammation and glucose homeostasis. Domestic animal endocrinology 42, 129-41,

Tvarijonaviciute A, Ceron JJ, Holden SL, Cuthbertson DJ, Biourge V, Morris PJ, German AJ. 2012b Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC veterinary research 8, 1-8,

Ussar S, Lee KY, Dankel SN, Boucher J, Haering M-F, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM. 2014 ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science translational medicine 6, 247ra103-247ra103,

Usui S, Yasuda H, Koketsu Y. 2016 Characteristics of obese or overweight dogs visiting private Japanese veterinary clinics. Asian Pacific Journal of Tropical Biomedicine 6, 338-43,

Van de Velde H, Janssens G, Rochus K, Duchateau L, Scharek-Tedin L, Zentek J, Nguyen P, Cox E, Buyse J, Biourge V. 2013 Proliferation capacity of T-lymphocytes is affected transiently after a long-term weight gain in Beagle dogs. Veterinary immunology and immunopathology 152, 237-44,

Van de Velde H, Janssens G, Stuyven E, Cox E, Buyse J, Hesta M. 2012 Short-term increase of body weight triggers immunological variables in dogs. Veterinary immunology and immunopathology 145, 431-7,

van Hagen MA, Ducro BJ, van den Broek J, Knol BW. 2005 Incidence, risk factors, and heritability estimates of hind limb lameness caused by hip dysplasia in a birth cohort of boxers. American journal of veterinary research 66, 307-12,

Van Vliet BN, Hall JE, Mizelle HL, Montani J-P, Smith Jr MJ. 1995 Reduced parasympathetic control of heart rate in obese dogs. American Journal of Physiology-Heart and Circulatory Physiology 269, H629-H37,

Van Winkle T, Bruce E. 1993 Thrombosis of the portal vein in eleven dogs. Veterinary pathology 30, 28-35,

Vedantam G, Viswanathan V. 2012 Leptin signaling protects the gut from Entamoeba histolytica infection. Gut Microbes 3, 2-3,

Velasquez-Mieyer PA, Cowan P, Arheart K, Buffington C, Spencer K, Connelly B, Cowan G, Lustig R. 2003 Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults. International journal of obesity 27, 219-26,

Verkest K, Fleeman L, Morton J, Groen S, Suchodolski J, Steiner J, Rand J. 2012 Association of postprandial serum triglyceride concentration and serum canine pancreatic lipase immunoreactivity in overweight and obese dogs. Journal of Veterinary Internal Medicine 26, 46-53,

Verkest K, Fleeman L, Morton J, Ishioka K, Rand J. 2011a Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis. Domestic animal endocrinology 41, 24-34,

Verkest K, Rose F, Fleeman L, Rand J, Morton J, Richards A, Ishioka K, Whitehead J. 2011b Adiposity and adiponectin in dogs: investigation of causes of discrepant results between two studies. Domestic animal endocrinology 41, 35-41,

Verkest KR. 2014 Is the metabolic syndrome a useful clinical concept in dogs? A review of the evidence. The Veterinary Journal 199, 24-30,

Vermeulen A, Kaufman J, Deslypere J, Thomas G. 1993 Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. The Journal of Clinical Endocrinology & Metabolism 76, 1140-6,

von Haehling S, Lainscak M, Springer J, Anker SD. 2009 Cardiac cachexia: a systematic overview. Pharmacology & therapeutics 121, 227-52,

Wakshlag JJ, Struble AM, Levine CB, Bushey JJ, Laflamme DP, Long GM. 2011 The effects of weight loss on adipokines and markers of inflammation in dogs. British journal of nutrition 106, S11-S4,

Wang M, Chen F, Wang J, Zeng Z, Yang Q, Shao S. 2018 Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients. Clinical Immunology 197, 77-85,

Wasim M, Awan FR, Najam SS, Khan AR, Khan HN. 2016 Role of leptin deficiency, inefficiency, and leptin receptors in obesity. Biochemical Genetics 54, 565-72,

Watanabe T, Nomura M, Nakayasu K, Kawano T, Ito S, Nakaya Y. 2006 Relationships between thermic effect of food, insulin resistance and autonomic nervous activity. The Journal of Medical Investigation 53, 153-8,

Weeth LP. 2016 Other risks/possible benefits of obesity. Veterinary Clinics: Small Animal Practice 46, 843-53,

Whiteside SA, Razvi H, Dave S, Reid G, Burton JP. 2015 The microbiome of the urinary tract—a role beyond infection. Nature Reviews Urology 12, 81-90,

Wozniak SE, Gee LL, Wachtel MS, Frezza EE. 2009 Adipose tissue: the new endocrine organ? A review article. Digestive diseases and sciences 54, 1847-56,

Wynn SG, Witzel AL, Bartges JW, Moyers TS, Kirk CA. 2016 Prevalence of asymptomatic urinary tract infections in morbidly obese dogs. PeerJ 4, e1711,

Wynne K, Stanley S, McGowan B, Bloom S. 2005 Appetite control. Journal of endocrinology 184, 291-318,

Xenoulis P, Steiner J. 2015 Canine hyperlipidaemia. Journal of Small Animal Practice 56, 595-605,

Yam PS, Naughton G, Butowski CF, Root AL. 2017 Inaccurate assessment of canine body condition score, bodyweight, and pet food labels: a potential cause of inaccurate feeding. Veterinary sciences 4, 30,

Yamashita T, Murakami T, Otani S, Kuwajima M, Shima K. 1998 Leptin receptor signal transduction: OBRa and OBRb offaType. Biochemical and biophysical research communications 246, 752-9,

Yamka RM, Friesen KG, Frantz NZ. 2006 Identification of canine markers related to obesity and the effects of weight loss on the markers of interest. International Journal of Applied Research in Veterinary Medicine 4, 282,

Yang W-S, Lee W-J, Funahashi T, Tanaka S, Matsuzawa Y, Chao C-L, Chen C-L, Tai T-Y, Chuang L-M. 2001 Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. The Journal of Clinical Endocrinology & Metabolism 86, 3815-9,

Yki-Jarvinen H, Kubo K, Zawadzki J, Lillioja S, Young A, Abbott W, Foley JE. 1987 Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM. American Journal of Physiology-Endocrinology and Metabolism 253, E300-E4,

Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. 2013 mTORC1 couples immune signals and metabolic programming to establish Treg-cell function. Nature 499, 485-90,

Zoran DL. 2010 Obesity in dogs and cats: a metabolic and endocrine disorder. Veterinary Clinics: Small Animal Practice 40, 221-39,

Zou C, Shao J. 2008 Role of adipocytokines in obesity-associated insulin resistance. The Journal of nutritional biochemistry 19, 277-86,