Recent progress in plant-derived antiviral compounds against African swine fever virus https://doi.org/10.12982/VIS.2024.066
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Abstract
African Swine Fever Virus (ASFV) poses a significant threat to the global swine industry, necessitating the development of effective therapeutic strategies. Through a detailed exploration of ASFV biology, pathogenesis, and replication cycle, critical targets for intervention were identified. The aim of this review was to evaluate the antiviral activity of different plant-derived compounds against ASFV, discuss research gaps, and highlight future perspectives. Key findings from the literature highlight the diverse mechanisms by which plant-derived compounds exert their antiviral effects on ASFV. Notably, flavonoids, alkaloids, and terpenoids exhibit promising antiviral potential via distinct modes of action. However, research gaps persist in the understanding of the precise mechanisms of action, strain-specific effects, and potential toxicity. With a growing understanding of ASFV biology and its intricate replication cycle, these compounds offer a promising avenue for intervention. Addressing research gaps and optimizing formulations are vital for translating these findings into effective therapeutic solutions. Interdisciplinary collaborations in virology, pharmacology, and plant science present an opportunity to combat ASFV, ensuring the security of the food supply and animal health on a global scale.
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