Crimean–Congo Hemorrhagic Fever (CCHF): An integrated overview https://doi.org/10.12982/VIS.2026.013
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Abstract
CCHF (Crimean-Congo hemorrhagic fever), is an illness transmitted by a lethal virus with a high case mortality rate and widespread geographic distribution, is transmitted by ticks. Nations in Africa, the Middle East, Asia, and southern and eastern Europe all report cases of CCHF. The public's health is seriously threatened by the lack of study and the possibility of the endemic spread of the disease. The current review aimed to highlight the information gaps beside the undiscovered areas when researching the virus that causes Crimean-Congo hemorrhagic fever. Additionally, it included information on the epidemiology, etiology, transmission, clinical traits, diagnosis, therapy, and preventative and control strategies of the virus. Animals are asymptomatic, so this illness does not affect them as much. However, domestic livestock are crucial in the spread of disease to people. Therefore, people who work in slaughterhouses, farms, or as veterinarians run a risk of catching this illness. A rapid diagnosis is crucial since the condition has significant public health implications. Real-time PCR enables fast diagnosis of CCHF. Future studies should concentrate on the molecular causes of CCHFV infection and how to treat it because there are still many unanswered questions in these fields. In endemic locations, an array of preventative measures must be placed in place, including education, lowering tick contact, minimizing tick infestations in livestock, controlling tick infestations, quarantining livestock, and shielding populations at risk from high-risk exposure activities.
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References
Ahmad, S., Hashmi, N., Siddiqui, J.A., Siddiqui, A., Ahmad, S., Hashim, H.T., Essar, M.Y., 2022. The nosebleed fever outbreak in iraq: Challenges, efforts and recommendations. Ann. Med. Surg. 79, 104077.
Akinci, E., Bodur, H., Sunbul, M., Leblebicioglu, H., 2016. Prognostic factors, pathophysiology and novel biomarkers in crimean-congo hemorrhagic fever. Antivir. Res. 132, 233-243.
Akira, S., 1999. Functional roles of stat family proteins: lessons from knockout mice. Stem Cells. 17(3), 138-146.
Al-Rubaye, D., Al-Rubaye, T.S., Shaker, M., Naif, H.M., 2022. Recent outbreaks of crimean–congo hemorrhagic fever (CCHF) in Iraq. Sci. Arch. 3, 109-112.
Al-Shauwreed, A.K.M., Hamadi, S.S., Issa, A.H., Saud, H.A., Alshami, I.J.J., Fares, M.N., 2023. Evolutionary and historical study of crimean-congo hemorrhagic fever virus (cchfv). Med. J. Basrah Univ. 41(1), 12-25.
Al-Tikriti, S., Al-Ani, F., Jurji, F., Tantawi, H., Al-Moslih, M., Al-Janabi, N., Mahmud, M., Al-Bana, A., Habib, H., Al-Munthri, H., 1981. Congo/crimean haemorrhagic fever in iraq. Bull World Health Organ. 59(1), 85.
Alam, M.M., Khurshid, A., Sharif, S., Shaukat, S., Suleman, R.M., Angez, M., Zaidi, S.S.Z., 2013. Crimean-congo hemorrhagic fever asia-2 genotype, pakistan. Emerg. Infect. Dis. 19(6), 1017.
Andersson, I., Karlberg, H., Mousavi‐Jazi, M., Martínez‐Sobrido, L., Weber, F., Mirazimi, A., 2008. Crimean‐congo hemorrhagic fever virus delays activation of the innate immune response. J. Med. Virol. 80(8), 1397-1404.
Appannanavar, S.B., Mishra, B., 2011. An update on crimean congo hemorrhagic fever. J. Glob. Infect. 3(3), 285.
Ascioglu, S., Leblebicioglu, H., Vahaboglu, H., Chan, K.A., 2011. Ribavirin for patients with crimean–congo haemorrhagic fever: A systematic review and meta-analysis. J. Antimicrob. Chemother. 66(6), 1215-1222.
Aslam, S., Latif, M.S., Daud, M., Rahman, Z.U., Tabassum, B., Riaz, M.S., Khan, A., Tariq, M., Husnain, T., 2016. Crimean‑congo hemorrhagic fever: risk factors and control measures for the infection abatement. Biomed. Rep. 4(1), 15-20.
Bente, D.A., Alimonti, J.B., Shieh, W.J., Camus, G., Stroher, U., Zaki, S., Jones, S.M., 2010. Pathogenesis and immune response of crimean-congo hemorrhagic fever virus in a stat-1 knockout mouse model. J. Virol. 84(21), 11089-11100.
Bente, D.A., Forrester, N.L., Watts, D.M., Mcauley, A.J., Whitehouse, C.A., Bray, M., 2013. Crimean-congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antivir. Res. 100(1), 159-189.
Bereczky, S., Lindegren, G., Karlberg, H., Akerstrom, S., Klingstrom, J., Mirazimi, A., 2010. Crimean–congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice. J. Gen. Virol. 91(6), 1473-1477.
Blacksell, S.D., Dhawan, S., Kusumoto, M., Le, K.K., Summermatter, K., O'keefe, J., Kozlovac, J., Almuhairi, S.S., Sendow, I., Scheel, C.M., 2023. The biosafety research road map: The search for evidence to support practices in the laboratory—crimean congo haemorrhagic fever virus and lassa virus. Appl. Biosaf. 28(4), 216-229.
Bodur, H., Akinci, E., Ascioglu, S., Öngürü, P., Uyar, Y., 2012. Subclinical infections with crimean-congo hemorrhagic fever virus, Turkey. Emerg. Infect. Dis. 18(4), 640.
Bodur, H., Akıncı, E., Öngürü, P., Carhan, A., Uyar, Y., Tanrıcı, A., Cataloluk, O., Kubar, A., 2010. Detection of crimean-congo hemorrhagic fever virus genome in saliva and urine. Int. J. Infect. Dis. 14(3), e247-e249.
Bodur, H., Erbay, A., Akıncı, E., Öngürü, P., Bayazıt, N., Eren, S.S., Kubar, A., 2011. Effect of oral ribavirin treatment on the viral load and disease progression in crimean-congo hemorrhagic fever. Int. J. Infect. Dis. 15(1), e44-e47.
Bonney, L.C., Watson, R.J., Afrough, B., Mullojonova, M., Dzhuraeva, V., Tishkova, F., Hewson, R., 2017. A recombinase polymerase amplification assay for rapid detection of crimean-congo haemorrhagic fever virus infection. PLoS Negl. Trop. Dis. 11(10), e0006013.
Brinkmann, A., Ergünay, K., Radonić, A., Kocak Tufan, Z., Domingo, C., Nitsche, A., 2017. Development and preliminary evaluation of a multiplexed amplification and next generation sequencing method for viral hemorrhagic fever diagnostics. PLoS Negl. Trop. Dis. 11(11), e0006075.
Burt, F., Leman, P., Abbott, J., Swanepoel, R., 1994. Serodiagnosis of crimean-congo haemorrhagic fever. Epidemiol. Infect. 113(3), 551-562.
Burt, F., Leman, P., Smith, J., Swanepoel, R., 1998. The use of a reverse transcription–polymerase chain reaction for the detection of viral nucleic acid in the diagnosis of crimean–congo haemorrhagic fever. J. Virol. Methods. 70(2), 129-137.
Carroll, S.A., Bird, B.H., Rollin, P.E., Nichol, S.T., 2010. Ancient common ancestry of crimean-congo hemorrhagic fever virus. Mol. Phylogenet. Evol. 55(3), 1103-1110.
Carter, S.D., Surtees, R., Walter, C.T., Ariza, A., Bergeron, É., Nichol, S.T., Hiscox, J.A., Edwards, T.A., Barr, J.N., 2012. Structure, function, and evolution of the crimean-congo hemorrhagic fever virus nucleocapsid protein. J. Virol. 86(20), 10914-10923.
Casals, J., 1969. Antigenic similarity between the virus causing crimean hemorrhagic fever and congo virus. Proc. Soc. Exp. Biol. Med. 131(1), 233-236.
Çevik, M.A., Erbay, A., Bodur, H., Eren, S.S., Akinci, E., Şener, K., Öngürü, P., Kubar, A., 2007. Viral load as a predictor of outcome in crimean-congo hemorrhagic fever. Clin. Infect. Dis. 45(7), e96-e100.
Charrel, R.N., Attoui, H., Butenko, A., Clegg, J., Deubel, V., Frolova, T., Gould, E., Gritsun, T., Heinz, F., Labuda, M., 2004. Tick-borne virus diseases of human interest in Europe. Clin. Microbiol. Infect. 10(12), 1040-1055.
Chumankov, M., Butenko, A., Shalunova, N., Mart’ianova, L., Smirnova, S., Bashkiritsev, I., Zavodova, T., Rubin, S., Tkachenko, E., Karmysheva, V., 1968. New data on the viral agent of crime an hemorrhagic fever. Vopr. Virusol. 13, 377.
Crowcroft, N., Morgan, D., Brown, D., 2002. Viral haemorrhagic fevers in europe–effective control requires a co-ordinated response. Euro. Surveill. 7(3), 31-32.
Dakhil, A.A., Saleh, W.M.M., Al-Taher, S.S.H., Alqaisi, K.A.K., Naji, M.M., AbdulRasool, L.M.S., 2024. Seroepidemiological survey of Crimean-Congo Hemorrhagic Fever (CCHF) in small ruminants after a recent human outbreak in Basra governorate, southern Iraq in 2023. Consultant. 64(6):627-634.
De La Calle-Prieto, F., Martín-Quirós, A., Trigo, E., Mora-Rillo, M., Arsuaga, M., Díaz-Menéndez, M., Arribas, J.R., 2018. Therapeutic management of crimean-congo haemorrhagic fever. Enferm. Infecc. Microbiol. Clin. (Engl. Ed.) 36(8), 517-522.
Drosten, C., Gottig, S., Schilling, S., Asper, M., Panning, M., Schmitz, H., GüNther, S., 2002. Rapid detection and quantification of rna of ebola and marburg viruses, lassa virus, crimean-congo hemorrhagic fever virus, rift valley fever virus, dengue virus, and yellow fever virus by real-time reverse transcription-pcr. J. Clin. Microbiol. 40(7), 2323-2330.
Drosten, C., Kümmerer, B.M., Schmitz, H., Günther, S., 2003. Molecular diagnostics of viral hemorrhagic fevers. Antivir. Res. 57(1-2), 61-87.
Duh, D., Saksida, A., Petrovec, M., Ahmeti, S., Dedushaj, I., Panning, M., Drosten, C., Avšič-Županc, T., 2007. Viral load as predictor of crimean-congo hemorrhagic fever outcome. Emerg. Infect. Dis. 13(11), 1769.
Duh, D., Saksida, A., Petrovec, M., Dedushaj, I., Avšič-Županc, T., 2006. Novel one-step real-time rt-pcr assay for rapid and specific diagnosis of crimean-congo hemorrhagic fever encountered in the balkans. J. Virol. Methods. 133(2), 175-179.
Ergönül, Ö., 2006. Crimean-congo haemorrhagic fever. Lancet. Infect. Dis. 6(4), 203-214.
Ergönül, Ö., 2014. Chapter 10—Crimean-Congo Hemorrhagic Fever. In: Emerg. Infect. Dis. Amsterdam: Academic Press; p:135–148.
Ergönül, Ö., Çelikbaş, A., Dokuzoğuz, B., Eren, Ş., Baykam, N., Esener, H., 2004. Characteristics of patients with crimean-congo hemorrhagic fever in a recent outbreak in turkey and impact of oral ribavirin therapy. Clin. Infect. Dis. 39(2), 284-287.
Ergönül, Ö., Tuncbilek, S., Baykam, N., Celikbas, A., Dokuzoguz, B., 2006. Evaluation of serum levels of interleukin (il)–6, il-10, and tumor necrosis factor–α in patients with crimean-congo hemorrhagic fever. J. Infect. Dis. 193(7), 941-944.
Ergönül, Ö., Whitehouse, C.A., 2007. Clinical and pathological features of Crimean-Congo hemorrhagic fever. In: Ergonul, O., Whitehouse, C.A. (Eds.), Crimean-Congo haemorrhagic fever: global perspective. Springer, Dordrecht, pp. 207-220.
Escadafal, C., Ölschläger, S., Avšič-Županc, T., Papa, A., Vanhomwegen, J., Wölfel, R., Mirazimi, A., Teichmann, A., Donoso-Mantke, O., Niedrig, M., 2012. First international external quality assessment of molecular detection of crimean-congo hemorrhagic fever virus. PLoS Negl. Trop. Dis. 6(6), e1706.
Fagbami, A., Tomori, O., Fabiyi, A., Isoun, T., 1975. Experimantal congo virus (Ib-AN 7620) infection in primates. Virologie. 26(1), 33-37.
Fernandez-Garcia, M.D., Negredo, A., Papa, A., Donoso-Mantke, O., Niedrig, M., Zeller, H., Tenorio, A., Franco, L., The Enivd Members, C., 2014. European survey on laboratory preparedness, response and diagnostic capacity for crimean-congo haemorrhagic fever, 2012. Euro. Surveill. 19(26), 20844.
Filippone, C., Marianneau, P., Murri, S., Mollard, N., Avsic-Zupanc, T., Chinikar, S., Despres, P., Caro, V., Gessain, A., Berthet, N., 2013. Molecular diagnostic and genetic characterization of highly pathogenic viruses: Application during crimean–congo haemorrhagic fever virus outbreaks in eastern europe and the middle east. Clin. Microbiol. Infect. 19(2), E118-E128.
Fillâtre, P., Revest, M., Tattevin, P., 2019. Crimean-congo hemorrhagic fever: an update. Med. Mal. Infect. 49(8), 574-585.
Gargili, A., Estrada-Peña, A., Spengler, J.R., Lukashev, A., Nuttall, P.A., Bente, D.A., 2017. The role of ticks in the maintenance and transmission of crimean-congo hemorrhagic fever virus: a review of published field and laboratory studies. Antivir. Res. 144, 93-119.
Garrison, A.R., Smith, D.R., Golden, J.W., 2019. Animal models for crimean-congo hemorrhagic fever human disease. Viruses. 11(7), 590.
Gonzalez, J.P., Camicas, J.L., Cornet, J.P., Faye, O., Wilson, M., 1992. Sexual and transovarian transmission of crimean-congo haemorrhagic fever virus in hyalomma truncatum ticks. Res. Virol. 143, 23-28.
Gowen, B.B., Holbrook, M.R., 2008. Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses. Antivir. Res. 78(1), 79-90.
Guo, Y., Wang, W., Ji, W., Deng, M., Sun, Y., Zhou, H., Yang, C., Deng, F., Wang, H., Hu, Z., 2012. Crimean–congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. Proc. Natl. Acad. Sci. 109(13), 5046-5051.
Hasanoglu, I., Guner, R., Carhan, A.K., Tufan, Z.Y., Caglayik, D., Yilmaz, G.R., Tasyaran, M.A., 2018. Dynamics of viral load in crimean congo hemorrhagic fever. J. Med. Virol. 90(4), 639-643.
Hawman, D.W., Meade-White, K., Haddock, E., Habib, R., Scott, D., Thomas, T., Rosenke, R., Feldmann, H., 2019. Crimean-congo hemorrhagic fever mouse model recapitulating human convalescence. J. Virol. 93(18), e00554-00519.
Hepojoki, J., Strandin, T., Wang, H., Vapalahti, O., Vaheri, A., Lankinen, H., 2010. Cytoplasmic tails of hantavirus glycoproteins interact with the nucleocapsid protein. J. Gen. Virol. 91(9), 2341-2350.
Hoogstraal, H., 1979. The epidemiology of tick-borne crimean-congo hemorrhagic fever in Asia, Europe, and Africa. J. Med. Entomol. 15(4), 307-417.
Jabbari, A., Besharat, S., Abbasi, A., 2008. Some evidences about crimean congo hemorrhagic fever. Pak. J. Med. Sci. 24(1), 187-188.
Jabbari, A., Besharat, S., Abbasi, A., Moradi, A., Kalavi, K., 2006. Crimean-congo hemorrhagic fever: Case series from a medical center in golestan province, northeast of iran (2004-2006). Indian J. Med. Sci. 60(8), 327-329.
Koehler, J.W., Delp, K.L., Hall, A.T., Olschner, S.P., Kearney, B.J., Garrison, A.R., Altamura, L.A., Rossi, C.A., Minogue, T.D., 2018. Sequence optimized real-time reverse transcription polymerase chain reaction assay for detection of crimean-congo hemorrhagic fever virus. Am. J. Trop. Med. Hyg. 98(1), 211.
Leblebicioglu, H., Bodur, H., Dokuzoguz, B., Elaldi, N., Guner, R., Koksal, I., Kurt, H., Senturk, G.C., 2012. Case management and supportive treatment for patients with crimean-congo hemorrhagic fever. Vector Borne Zoonotic. Dis. 12(9), 805-811.
Lindquist, M.E., Zeng, X., Altamura, L.A., Daye, S.P., Delp, K.L., Blancett, C., Coffin, K.M., Koehler, J.W., Coyne, S., Shoemaker, C.J., 2018. Exploring Crimean-Congo hemorrhagic fever virus-induced hepatic injury using antibody-mediated type I interferon blockade in mice. J. Virol. 92(21), e01083-01018.
Maltezou, H.C., Papa, A., 2010. Crimean–congo hemorrhagic fever: risk for emergence of new endemic foci in Europe?. Travel Med. Infect. Dis. 8(3), 139-143.
Mazzola, L.T., Kelly-Cirino, C., 2019. Diagnostic tests for crimean-congo haemorrhagic fever: a widespread tickborne disease. BMJ Glob. Health. 4(Suppl 2), e001114.
Mehravaran, A., Moradi, M., Telmadarraiy, Z., Mostafavi, E., Moradi, A. R., Khakifirouz, S., Shah-Hosseini, N., Varaie, F.S.R., Jalali, T., Hekmat, S., 2013. Molecular detection of crimean-congo haemorrhagic fever (CCHF) virus in ticks from southeastern Iran. Ticks Tick Borne Dis. 4(1-2), 35-38.
Meraz, M.A., White, J.M., Sheehan, K.C., Bach, E.A., Rodig, S.J., Dighe, A.S., Kaplan, D.H., Riley, J.K., Greenlund, A.C., Campbell, D., 1996. Targeted disruption of the stat1 gene in mice reveals unexpected physiologic specificity in the jak–stat signaling pathway. Cell. 84(3), 431-442.
Mertens, M., Schmidt, K., Ozkul, A., Groschup, M.H., 2013. The impact of crimean-congo hemorrhagic fever virus on public health. Antivir. Res. 98(2), 248-260.
Mild, M., Simon, M., Albert, J., Mirazimi, A., 2010. Towards an understanding of the migration of crimean–congo hemorrhagic fever virus. J. Gen. Virol. 91(1), 199-207.
Morrill, J.C., Jennings, G.B., Cosgriff, T.M., Gibbs, P.H., Peters, C., 1989. Prevention of rift valley fever in rhesus monkeys with interferon-α. Rev. Infect. Dis. 11(Supplement_4), S815-S825.
Mukherjee, D., Roy, S., Iturburu, A., Jaiswal, V., 2022. Crimean congo hemorrhagic fever in covid 19 times, an emerging concern in Iraq. Ann. Med. Surg. 80, 104243.
Nubgan, A., Al-Saadi, M., 2023. Crimean-congo hemorrhagic fever favouring factors virus transmission: Special focus on iraq and neighbouring countries. Vet. Integr. Sci. 21(3), 865-877.
Oestereich, L., Rieger, T., Neumann, M., Bernreuther, C., Lehmann, M., Krasemann, S., Wurr, S., Emmerich, P., De Lamballerie, X., Ölschläger, S., 2014. Evaluation of antiviral efficacy of ribavirin, arbidol, and t-705 (favipiravir) in a mouse model for crimean-congo hemorrhagic fever. PLoS Negl. Trop. Dis. 8(5), e2804.
Okorie, T.G., 1991. Comparative studies on the vector capacity of the different stages of amblyomma variegatum fabricius and hyalomma rufipes koch for congo virus, after intracoelomic inoculation. Vet. Parasitol. 38(2-3), 215-223.
Overby, A.K., Pettersson, R.F., Neve, E.P., 2007. The glycoprotein cytoplasmic tail of uukuniemi virus (bunyaviridae) interacts with ribonucleoproteins and is critical for genome packaging. J. Virol. 81(7), 3198-3205.
Papa, A., Papadopoulou, E., Tsioka, K., Kontana, A., Pappa, S., Melidou, A., Giadinis, N.D., 2018. Isolation and whole-genome sequencing of a crimean-congo hemorrhagic fever virus strain, greece. Ticks. Tick. Borne. Dis. 9(4), 788-791.
Papa, A., Sidira, P., Tsatsaris, A., 2016. Spatial cluster analysis of crimean-congo hemorrhagic fever virus seroprevalence in humans, greece. Parasite Epidemiol. Control. 1(3), 211-218.
Pshenichnaya, N.Y., Sydenko, I.S., Klinovaya, E.P., Romanova, E.B., Zhuravlev, A.S., 2016. Possible sexual transmission of crimean-congo hemorrhagic fever. Int. J. Infect. Dis. 45, 109-111.
Ribeiro, D., Borst, J.W., Goldbach, R., Kormelink, R., 2009. Tomato spotted wilt virus nucleocapsid protein interacts with both viral glycoproteins GN and GC in planta. Virol. 383(1), 121-130.
Roberts, T., Bygrave, H., Fajardo, E., Ford, N., 2012. Challenges and opportunities for the implementation of virological testing in resource‐limited settings. J. Int. AIDS Soc. 15(2), 17324.
Rodriguez, S.E., Hawman, D.W., Sorvillo, T.E., O'neal, T.J., Bird, B.H., Rodriguez, L.L., Bergeron, É., Nichol, S.T., Montgomery, J.M., Spiropoulou, C.F., 2022. Immunobiology of crimean-congo hemorrhagic fever. Antivir. Res. 105244.
S Al-Yabis, A., Al-Thamery, A.K., Hasony, J.H., 2005. Seroepidemiology of crimean-congo haemorrhagic fever in rural community of basrah. Med. J. Basrah Univ. 23(2), 30-35.
Sah, R., Mohanty, A., Mehta, V., Chakraborty, S., Chakraborty, C., Dhama, K., 2022. Crimean-congo haemorrhagic fever (CCHF) outbreak in iraq: Currently emerging situation and mitigation strategies–correspondence. Int. J. Surg. 106, 106916.
Saleh, W.M.M., Dakhil A.A., Al-Taher, S.S.H., Naji, M.M., AbdulRasool L.M.S., Alqaisi K.A.K., 2025. Seroepidemiological study of crimean-congo hemorrhagic fever (CCHF) in small ruminants in Thi-qar governorate, southern Iraq, 2023. Adv. Anim. Vet. Sci. 13(2):365-371.
Saluzzo, J.F., Le Guenno, B., 1987. Rapid diagnosis of human crimean-congo hemorrhagic fever and detection of the virus in naturally infected ticks. J. Clin. Microbiol. 25(5), 922-924.
Schmaljohn, C., Nichol, S.T., 2007. Bunyaviridae. In: Fields, B.N., Knipe, D.M., Howley, P.M. (Eds.), Fields virology, (5th edition). Lippincott, Williams & Wilkins, Philadelphia, pp. 1741–1789.
Shapiro, S., Barkagan, Z., 1960. On history of hemorrhagic fever in middle Asia. Vopr. Virusol. 5, 245-246.
Shayan, S., Bokaean, M., Shahrivar, M.R., Chinikar, S., 2015. Crimean-Congo hemorrhagic fever. Lab. Med. 46(3), 180-189.
Shepherd, A., Leman, P., Swanepoel, R., 1989. Viremia and antibody response of small african and laboratory animals to crimean-congo hemorrhagic fever virus infection. Am. J. Trop. Med. Hyg. 40(5), 541-547.
Shepherd, A., Swanepoel, R., Gill, D., 1988. Evaluation of enzyme-linked immunosorbent assay and reversed passive hemagglutination for detection of crimean-congo hemorrhagic fever virus antigen. J. Clin. Microbiol. 26(2), 347-353.
Shi, X., Kohl, A., Li, P., Elliott, R.M., 2007. Role of the cytoplasmic tail domains of bunyamwera orthobunyavirus glycoproteins gn and gc in virus assembly and morphogenesis. J. Virol. 81(18), 10151-10160.
Simpson, D.I., Knight, E.M., Courtois, G., Williams, M.C., Weinbren, M.P., Kibukamusoke, J., 1967. Congo virus: a hitherto undescribed virus occurring in africa. Part 1. Human isolations-clinical notes. East. Afr. Med. J. 44(2), 87-92.
Smego Jr, R.A., Sarwari, A.R., Siddiqui, A.R., 2004. Crimean-congo hemorrhagic fever: prevention and control limitations in a resource-poor country. Clin. Infect. Dis. 38(12), 1731-1735.
Smirnova, S., 1979. A comparative study of the crimean hemorrhagic fever-congo group of viruses. Arch. Virol. 62(2), 137-143.
Snippe, M., Borst, J.W., Goldbach, R., Kormelink, R., 2007. Tomato spotted wilt virus Gc and N proteins interact in vivo. Virol. 357(2), 115-123.
Telmadarraiy, Z., Chinikar, S., Vatandoost, H., Faghihi, F., Hosseini-Chegeni, A., 2015. Vectors of crimean congo hemorrhagic fever virus in Iran. J. Arthropod. Borne Dis. 9(2), 137.
Tignor, G.H., Hanham, C.A., 1993. Ribavirin efficacy in an in vivo model of crimean-congo hemorrhagic fever virus (CCHF) infection. Antivir. Res. 22(4), 309-325.
Van Leeuwen, L.P., De Jong, W., Doornekamp, L., Van Gorp, E.C., Wismans, P.J., Goeijenbier, M., 2022. Exotic viral hepatitis; a review on epidemiology, pathogenesis, and treatment. J. Hepatol. 77(5), 1431-1443
Vanhomwegen, J., Alves, M.J., Županc, T.A., Bino, S., Chinikar, S., Karlberg, H., Korukluoğlu, G., Korva, M., Mardani, M., Mirazimi, A., 2012. Diagnostic assays for crimean-congo hemorrhagic fever. Emerg. Infect. Dis. 18(12), 1958.
Vorou, R., Pierroutsakos, I.N., Maltezou, H.C., 2007. Crimean-congo hemorrhagic fever. Curr. Opin. Infect. Dis. 20(5), 495-500.
Wahid, B., Altaf, S., Naeem, N., Ilyas, N., Idrees, M., 2019. Scoping review of crimean-congo hemorrhagic fever (CCHF) literature and implications of future research. J. Coll. Physicians Surg. Pak. 29(6), 563-573.
Wang, S., Lifson, M.A., Inci, F., Liang, L.G., Sheng, Y.F., Demirci, U., 2016. Advances in addressing technical challenges of point-of-care diagnostics in resource-limited settings. Expert Rev. Mol. Diagn. 16(4), 449-459.
Whitehouse, C.A., 2004. Crimean–congo hemorrhagic fever. Antivir. Res. 64(3), 145-160.
Whitehouse, C.A., 2007. Risk groups and control measures for Crimean-Congo hemorrhagic fever. In: Ergonul, O., Whitehouse, C.A. (Eds.), Crimean-Congo hemorrhagic fever. Springer, Dordrecht. Available online: https://doi.org/10.1007/978-1-4020-6106-6_20
WHO, 2013. Crimean congo haemorrhagic fever. Fact sheet no. 208. Available online: http://www.who.int/mediacentre/factsheets/fs208/en/Acces
WHO, 2022a. Crimean-congo haemorrhagic fever. Available online: https://www.who.int/news-room/fact-sheets/detail/crimean-congo-haemorrhagic-fever
WHO, 2022b. Situation report Iraq week 32. Available online: https://iraq.un.org/en/195561
-who-situation-report-iraq-week-32
Wiktorowicz, C.J., Arnold, B., Wiktorowicz, J.E., Murray, M.L., Kurosky, A., 2017. Hemorrhagic fever virus, human blood, and tissues in iron age mortuary vessels. J. Archaeol. Sci. 78, 29-39.
Woodall, J., Williams, M., Simpson, D., 1967. Congo virus: a hitherto undescribed virus occurring in africa. Part 2. Identification studies. East Afr. Med. J. 44(2), 93-98.
Woodall, J.P., 2007. Personal reflections. In: Ergonul, O., Whitehouse, C.A. (Eds.), Crimean-Congo haemorrhagic fever: global perspective. Springer, Dordrecht, pp. 23-32.
Zivcec, M., Safronetz, D., Scott, D., Robertson, S., Ebihara, H., Feldmann, H., 2013. Lethal crimean-congo hemorrhagic fever virus infection in interferon α/β receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy. J. Infect. Dis. 207(12), 1909-1921.
