Study of the effects of new Lactobacillus strains on gut and oral microbiota in healthy dogs https://doi.org/10.12982/VIS.2026.048
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Abstract
Probiotics, particularly Lactobacillus spp., play a key role in supporting host health by modulating the gut and oral microbiota, enhancing immune responses, and maintaining microbial balance. While microbial diversity and composition are crucial for gastrointestinal and oral health, the impact of new Lactobacillus strains on healthy dogs has not been fully explored. This study evaluated the impact of new Lactobacillus strains on the gut and oral microbiota of healthy dogs. A sample of 35 adult dogs was divided into seven groups. Group 1 received a basal diet, while Groups 2–6 received individual Lactobacillus strain supplements: L. plantarum CM20-8 (TISTR 2676), L. acidophilus Im10 (TISTR 2734), L. rhamnosus L12-2 (TISTR 2716), L. paracasei KT-5 (TISTR 2688), and L. fermentum CM14-8 (TISTR 2720), respectively. Group 7 received a mixed probiotic supplement containing all five strains. Each dog received the respective L. strain at 10⁹ CFU/day. Fecal and oral microbiota were analyzed using 16S rRNA sequencing. Based on the results, probiotic supplementation did not significantly change the overall microbial diversity. Dogs supplemented with L. fermentum CM14-8 (TISTR 2720) had a significantly (p=0.02) higher abundance (1.97%) of the beneficial genus Faecalibacterium in fecal samples than the control group (0.64%). In oral microbiota, compared to the control group, there were significant (p=0.03) reductions in the abundance of the Desulfobacterota in dogs receiving L. acidophilus Im10 (2.19%), L. rhamnosus L12-2 (2.32%), L. paracasei KT-5 (2.59%), L. fermentum CM14-8 (2.11%), and the mixed probiotic (2.69%). These findings highlighted the potential of specific probiotic strains, especially L. fermentum CM14-8, to modulate oral and gut microbiota in healthy dogs. Further studies are essential in clinical populations and functional assessments to define their preventive and therapeutic applications.
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