Effects of Peperomia pellucida (L.) Kunth on the growth performances, and health of red hybrid tilapia (Oreochromis spp.) https://doi.org/10.12982/VIS.2026.063
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Abstract
Peperomia pellucida (PP), is an herb that has been proven rich in antioxidant property. However, the beneficial effects and mode of action of PP on disease resistance in fish are still unclear. In the present study, we revealed the potential impacts of PP on the growth performance, blood parameters, antioxidant capacity, immune-related gene expression and disease resistance against Aeromonas hydrophila in red hybrid tilapia, Oreochromis spp. Experimental fish were given a diet containing different doses of PP (100, 200 and 300 mg/kg diet) in triplicates for eight weeks. After feeding trials, the experimental fish were subjected to an intraperitoneal infection of A. hydrophila. Findings from the present study showed a significant (P < 0.05) improvement in growth performances (final weight, specific growth rate, and feed conversion rate), immune-related gene expression and disease resistance against A. hydrophila in fish fed PP supplemented diets in comparison to the control diet. Present study also demonstrated significant (P < 0.05) improvement in blood parameters by dietary PP provision. Dietary PP noticeably enhanced the antioxidant status of red hybrid tilapia with the increased activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) in the liver. On top of that, upregulation of growth and immune-related genes such as Lysozyme G (LysG), nuclear factor kappa B (NF-κB), transforming growth factor-β1 (TGF-β1), heat shock protein 90 (HSP90), and beta actin (β-actin) were also observed in the dietary PP group. Overall, polynomial regression analysis revealed that dietary PP at the dosage of 108 – 151 mg/kg improved growth and health performances of red hybrid tilapia
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