Comparison of Quality of Life in Thyroid Cancer Patients Before I-131 Radioactive lodine Therapy during 3rd and 4th Weeks of Thyroid Hormone Withdrawal
Keywords:
Quality of life, Thyroid cancer patients, I-131 Radioiodine therapy, Thyroid hormone withdrawalAbstract
Background: Thyroid cancer patients treated with radioactive iodine I-131 need to discontinue thyroid hormone medication before treatment to induce hypothyroidism. This can lead to adverse effects on the patient's physical, cognitive, and social functioning, thus deteriorating their quality of life. The appropriate duration for discontinuing thyroid hormone, whether it should be 3 or 4 weeks, remains undetermined. Objective: To compare the quality of life in thyroid cancer patients before I-131 treatment between those who discontinue thyroid hormone for 3 weeks and those who discontinue for 4 weeks. Methods: This was a quasi-experimental study. The sample consisted of 78 patients undergoing I-131 treatment, divided into two groups: one group discontinued thyroid hormone for 3 weeks, and the other for 4 weeks, with 39 patients in each group. Data collection was done using the Thai version of the thyroid cancer quality of life assessment tool. Data were analyzed using chi-square tests and independent t-tests to compare means between the two groups. Results: The general characteristics of the sample, including age, sex, marital status, education level, underlying diseases, and history of thyroid surgery, were not significantly different between the two groups (p-value > .05). Overall quality of life scores across all dimensions showed no significant difference between the 3-week and 4-week discontinuation groups (p-value = .360). Conclusion: Thyroid cancer patients treated with I-131 can discontinue thyroid hormone medication for either 3 or 4 weeks without affecting their quality of life.
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