Factors Predicting Consistent Use of Pre-Exposure Prophylaxis Among Men Who Have Sex with Men in Thailand: A Cross-Sectional Study
DOI:
https://doi.org/10.60099/prijnr.2026.277459Keywords:
Behavior, HIV infection, Men who have sex with men, Pre-exposure prophylaxis, Predicting factors, ThailandAbstract
HIV infection among men who have sex with men is increasing, and pre-exposure prophylaxis is an effective preventive strategy. Nevertheless, research on pre-exposure prophylaxis use behavior among men who have sex with men in Thailand is limited. This cross-sectional study aimed to identify factors predicting consistent use of pre-exposure prophylaxis among this group in Northeastern Thailand. The study included 128 men who have sex with men, selected through multistage sampling. Data were collected through an online survey platform using questionnaires, including a Demographic Data form, the Pre-Exposure Prophylaxis on Knowledge Questionnaire, the Attitude Questionnaire, the Stigma Questionnaire, the Perceived HIV Risk Questionnaire, the Self-Efficacy Questionnaire, and the Pre-Exposure Prophylaxis Use Behavior Questionnaire. Data collection was conducted October 2023 to August 2024. Data were analyzed using descriptive statistics, biserial correlation, and binary logistic regression analysis.
The results indicated that 39.8% of the participants reported consistent use of pre-exposure prophylaxis. Variables that were significantly correlated with regular use included attitude, stigma, and perceived HIV risk. The attitude and perceived HIV risk remained significant predictors among men who have sex with men, accounting for 41.8% of the variance. Nurses and other healthcare professionals may apply these findings to develop programs that promote positive attitudes, reduce stigma, and enhance perceived HIV risk, thereby increasing pre-exposure prophylaxis utilization among at-risk men who have sex with men. Future research should also examine additional influences, including media and community campaigns, partner support, accessibility of healthcare services and clinics, and healthcare providers’ attitudes toward men who have sex with men, to further advance understanding of pre-exposure prophylaxis utilization.
References
World Health Organization. Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022-2030. 2022 [cite 2025 Aug 27]. Available from: https://www.who.int/publications-detail-redirect/9789240053779
Division of AIDS and STIs, Department of Disease Control, Ministry of Public Health. HIV situation in Thailand, 2023. Nonthaburi: Department of Disease Control; 2023 [cited 2025 Aug 30]. Available from: https://hivhub.ddc.moph.go.th/officer/Download/RRTTR/HIV_Factsheet2023_TH_Final_021067.pdf. (in Thai)
Yang Z, Wei L, Xu Z, Li S, Xing Y, Zhang Y, et al. HIV risk and influencing factors among MSM who sought sexual partners in core venues: a continuous sentinel surveillance from 2010 to 2022. Front Public Health. 2024;12:1476642. doi: 10.3389/fpubh.2024.1476642.
Auemaneekul N, Lertpruek S, Satitvipawee P, Tuah NA. Pre-exposure prophylaxis uptake for HIV infection prevention among young men who have sex with men and transgender women in Bangkok, Thailand. J Health Res. 2021;35(5):434–443. doi:10.1108/JHR-10-2019-0242
Zhao Y, Li H, Huang Y, Zhou Z, He Z, Agins B, et al. HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: a systematic review and meta-analysis. Int J Infect Dis. 2025;154:107874. doi:10.1016/j.ijid.2025.107874.
Versteegh L, Amatavete S, Chinbunchorn T, Thammasiha N, Mukherjee S, Popping S, et al. The epidemiological impact and cost-effectiveness of key population-led PrEP delivery to prevent HIV among men who have sex with men in Thailand: A modelling study. Lancet Reg Health Southeast Asia. 2022;7:100097. doi: 10.1016/j.lansea.2022.100097
Sun Y, Lu H, Ye J, Li D, Li G. Awareness and use of HIV pre-exposure prophylaxis and factors associated with awareness among MSM in Beijing, China. Sci Rep. 2023;13(1):554. doi:10.1038/s41598-023-27485-8
Zhang G, Yang X, Kang W, Liu T, Cheng L, Qu M, et al. Pre-exposure prophylaxis uptake for high-risk men who have sex with men in China: a multi-city cross-sectional survey. AIDS Res Ther. 2023;20(1):32. doi:10.1186/s12981-023-00528-w
Ramautarsing RA, Meksena R, Sungsing T, Chinbunchorn T, Sangprasert T, Fungfoosri O, et al. Evaluation of a pre-exposure prophylaxis programme for men who have sex with men and transgender women in Thailand: learning through the HIV prevention cascade lens. J Int AIDS Soc. 2020;23(Suppl 3):e25540. doi:10.1002/jia2.25540
Stansfield SE, Moore M, Boily MC, Hughes JP, Donnell DJ, Dimitrov DT. Estimating benefits of using on-demand oral PrEP by MSM: a comparative modeling study of the US and Thailand. EClinicalMedicine. 2022;56:101776. doi:10.1016/j.eclinm.2022.101776
World Health Organization. Guidance on pre-exposure oral prophylaxis (PrEP) for serodiscordant couples, men and transgender women who have sex with men at high risk of HIV: recommendations for use in the context of demonstration projects. Geneva: World Health Organization; 2012 [cited 2025 Aug 27]. Available from: https://apps.who.int/iris/handle/10665/75191
Division of AIDS and STIs, Department of Disease Control, Ministry of Public Health. Thailand national guideline on pre-exposure prophylaxis: HIV-PrEP 2018. Nonthaburi: Department of Disease Control; 2018.
Patel RR, Crane JS, López J, Chan PA, Liu AY, Tooba R, et al. Pre-exposure prophylaxis for HIV prevention preferences among young adult African American men who have sex with men. PLoS One. 2018;13(12):e0209484. doi:10.1371/journal.pone.0209484
Tangpatomwong N. Familiarity, trust, and health behavior values: tendency of choosing PrEP and condom use or non-use among key populations at risk of HIV acquisition in the modern era. Thai AIDS J. 2020;32(3):79-93. doi:10.14456/taj.2020.7. (In Thai)
UNAIDS. UNAIDS and Global Fund sign a new strategic framework for their collaboration to end AIDS. Geneva: UNAIDS; 2024 [cited 2025 Aug 28]. Available from: https://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2024/june/20240624_global-fund
Department of Disease Control. Thailand national guidelines on HIV/AIDS diagnosis, treatment and prevention 2020/2021. Nonthaburi: Department of Disease Control; 2021 [cited 2025 Aug 30]. Available from: https://www.thaiaidssociety.org/wp-content/uploads/2022/02/Thailand-National-Guidelines-on-HIV-AIDS-Diagnosis-Treatment-and-Prevention-2020-2021.pdf (in Thai)
Rodriguez K, Kelvin EA, Grov C, Meyers K, Nash D, Wyka K. Exploration of the complex relationships among multilevel predictors of PrEP use among men who have sex with men in the United States. AIDS Behav. 2021;25:798–808. doi:10.1007/s10461-020-03039-1
Walsh JL. Applying the Information-Motivation-Behavioral Skills model to understand PrEP intentions and use among men who have sex with men. AIDS Behav. 2019;23(7):1904-1916. doi:10.1007/s10461-018-2371-3.
Chakrabath N, Auemaneekul N, Powwattana A. Predicting factors for pre-exposure prophylaxis PrEP taking-behaviors among men who have sex with men in Bangkok Metropolis. Royal Thai Navy Med J. 2021;48(3):611-630. (in Thai)
Eaton LA, Kalichman SC, Price D, Finneran S, Allen A, Maksut J. Stigma and conspiracy beliefs related to pre-exposure prophylaxis (PrEP) and interest in using PrEP among black and white men and transgender women who have sex with men. AIDS Behav. 2017; 21(5):1236-1246. doi:10.1007/s10461-017-1690-0
Knox J, Kutner BA, Shiau S, Winterhalter FS, Wu Y, Hirsch-Moverman Y, et al. Assessing the Information-Motivation-Behavioral Skills Model to predict pre-exposure prophylaxis adherence among black men who have sex with men and transgender women in a community setting in New York city. AIDS Behav. 2022;26(7):2494-2502. doi:10.1007/s10461-022-03588-7
Fisher JD, Fisher WA. The Information-Motivation-Behavioral Skills model of HIV prevention behavior. New York: Jossey-Bass;2009.
Dubov A, Altice FL, Fraenkel L. An Information-Motivation-Behavioral Skills model of PrEP uptake. AIDS Behav. 2018;22(11):3603-3616. doi:10.1007/s10461-018-2095-4
Naar S, Outlaw A, MacDonell K, Jones M, White J, Secord E, Templin T. Information-Motivation-Behavioral Skills model in youth newly starting antiretroviral treatment. AIDS Behav. 2023;27(8):2785-2790. doi:10.1007/s10461-023-04002-6
Lin B, Liu J, Pan H, et al. Longitudinal relationship between pre-exposure prophylaxis motivation and change in adherence among men who have sex with men in Western China. BMC Public Health. 2024;24(1):1271. doi:10.1186/s12889-024-18729-x
Longkul J, Promthet S, Bradshaw P. Utilisation of voluntary confidential counselling and testing for HIV by men who have sex with men in Northeastern Thailand. J Health Res. 2017;31(1):15-21.
Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175-191.
Lemeshow S, Hosmer DW Jr, Klar J, Lwanga SK. Adequacy of sample size in health studies. Chichester: John Wiley & Sons; 1990.
World Health Organization. Process of translation and adaptation of instruments. Geneva: World Health Organization; 2018.
Bloom BS. Handbook on formative and summative evaluation of student learning. New York: McGraw-Hill; 1971.
Sun S, Yang C, Zaller N, Zhang Z, Zhang H, Operario D. PrEP willingness and adherence self-efficacy among men who have sex with men with recent condomless anal sex in urban China. AIDS Behav. 2021;25:3482-3493. doi:10.1007/s10461-021-03274-0.
Dubov A, Galbo P, Altice FL, Fraenkel L. Stigma and shame experiences by MSM who take PrEP for HIV prevention: A qualitative study. Am J Mens Health. 2018;12(6):1843-1854. doi:10.1177/1557988318797437 ??
Fisher JD, Fisher WA. Changing AIDS-risk behavior. Psychol Bull. 1992;111(3):455-474.
Zhang C, Liu Y. Understanding the association between PrEP stigma and PrEP cascade moderated by the intensity of HIV testing. Trop Med Infect Dis. 2022;7(5):74. doi:10.3390/tropicalmed7050074
Yu YJ, Schieber E, Janamnuaysook R, Wang B, Gunasekar A, MacDonell K, Getwongsa P, Kim D, Wongharn P, Phanuphak N. Barriers and facilitators to pre-exposure prophylaxis (PrEP) uptake and adherence among men who have sex with men (MSM) in Thailand: a qualitative study. AIDS Care. 2024;36(8):1126-1134. doi:10.1080/09540121.2024.2332443.
Eaton L A, Driffin DD, Kegler C, Smith H, Conway-Washington C, White D, Cherry C. The role of stigma and medical mistrust in the routine health care engagement of black men who have sex with men. Am J Public Health. 2015;105(2):e75-e82. doi:10.2105/AJPH.2014.302322
Watson RJ, Chang CJ, Feinstein BA, Moody RL, Caba A, Eaton LA. PrEP stigma and logistical barriers remain significant challenges in curtailing HIV transmission among Black and Hispanic/Latinx cisgender sexual minority men and transgender women in the US. AIDS Care. 2022;34(11):1465-1472. doi:10.1080/09540121.2022.2098908
Maksut JL, Eaton LA, Driver R, Knowles CM, Watson RJ. Factors associated with awareness and use of pre-exposure prophylaxis (PrEP) among black men who have sex with men with a recent STI diagnosis. Behav Med. 2021;47(2):161-169. doi:10.1080/08964289.2019.1692776
Qu D, Zhong X, Lai M, Dai J, Liang H, Huang A. Influencing factors of pre-exposure prophylaxis self-efficacy among men who have sex with men. Am J Mens Health. 2019;13:1557988319847088. doi:10.1177/1557988319847088
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