Factors Effecting to Survival of Patients with Hepatocellular Carcinoma after Surgery Treatment
Keywords:
Hepatocellular carcinoma, survival, surgical treatmentAbstract
Objective : To investigate the factors affected to survival of patients with hepatocellular carcinoma (HCC) after receives surgical treatment.
Methods : A retrospective cohort study, data were collected from newly diagnosis of HCC and receives surgery at Roi Et Hospital during January 1, 2012 to December 31, 2015. All cases were follow-up the vital status until death or the end of study (March 31, 2016). All the variables of interest were retrieving from medical records and from cancer unit of Roi Et Hospital. The statistical analyses were used descriptive statistics, Kaplan Meier survival curves, Log-rank test and Cox proportional hazard model.
Result : Of 57 newly HCC diagnosis most of them were male 85.96%, mean age 63.77 years (+ SD=16.99). The total followup times were 1,103 person-months. The mortality rate was 3.44 per 100 person-months, median survival time of HCC after surgery was 15.8 months. The cumulative 3-, 6 months, 1-, 3 years survival rate were 89.47 %, 71.93 %, 64.64 % and 36.16 % respectively. After adjusted were found the factors affected to survival of HCC patient included metastasis of cancer (HR Adj. 1.72:95%CI;1.10- 3.59), chemotherapy (HR Adj. 3.34:95%CI; 1.38- 8.07), supportive treatment (HR Adj. 2.30:95%CI; 1.16-4.59) and cancer stage III (HR Adj. 5.67:95%CI; 1.18-27.31).
Conclusion : Ours study found the factors effected to survival of HCC patients after receives surgical treatment were metastasis of cancer, chemotherapy, supportive treatment and cancer stage III
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