Effect of Non-Surgical Periodontal Treatment on HbA1c level in Diabetic Type II Patients (NIDDM) : A meta-analysis

Abstract

              The two relationship of Diabetis Mellitus and Periodontal Disease has been noticed for a period of time. However, the exact interaction and impact between these disease still not clear. Especially, the question that periodontal treatment helps to control level of glycemia in the DM patients await for the answer.The purpose of this meta-analysis was to quantitatively find out whether periodontal treatments have effect on glycemic control for diabetics
type II (NIDDM) patients or not. PubMed database was systematically searched for related articles, together with searching in Biomed Central, Open Access, Google scholar and manual search at the Institute’s library. They were all filtered for articles in English from 2000 until 2018. Sixteen articles all RCTwere accepted and 16 datasets were extracted. Difference between pre-post glycemic control index of HbA1c, was calculated for weight mean difference
(WMD) at 95% CI and ramdom effect model was used. The result shows the decrease in HbA1c level in the diabetics patients that had periondontal treatment with adjuctive treatment (exclude adjuctive treatment that might effect systemic condition) was noticeable (WMD = -0.601%; 95%CI -0.759, -0.443; p = 0.000). Due to the hight heterogeneity of data (I2 = 83.5%) and a wide range of CI, subgroup analysis was done between the treatment group without adjuctive treatment and the group with adjuctive treatment. The results evidence suggests that high inconsistency was noted in both groups. The reason for heterogeneity remains obscure. However, the validity of the evidence is limited and further high-quality trials are needed.