Prevalence of maternal COVID-19 infection and obstetric outcomes among pregnant women with and without COVID-19 infectionat the time of delivery in Vachira phuket hospital
Keywords:
Pregnant women, COVID-19, Obstetric outcomesAbstract
Objectives : To study the prevalence of COVID-19 infection in pregnant women at the time of delivery and to describe the differences in outcomes between pregnant women with and without COVID-19 infection.
Methods : Retrospective comparative study of pregnant women consecutively admitted for delivery during August - October 2021, and universally tested via nasopharyngeal swab for SARS-CoV-2. Data were stratified by SARS-CoV-2 result and symptomatic status, and were summarized using parametric and nonparametric tests.
Results : Of 781 women admitted for delivery, 4.7% were tested positive for SARS-CoV-2, of whom 73% were asymptomatic. Obesity is common comorbidity in women with COVID-19(P-value=0.017). Cesarean section rates were 67.6% in women with COVID-19 and 50% in women without COVID-19(P-value = 0.037). Length of stay was increased in women with CoVID-19 (P-value < 0.001). Among the women with symptomatic COVID-19 infection, 80% needed oxygen support but non of them required mechanical ventilation, and no maternal death have occurred. No neonatal infection was found from SARS-CoV-2 positive pregnant women.
Conclusion : Among pregnant women with COVID-19 at delivery, we observed increased cesarean delivery rate and length of stay. No women required mechanical ventilation, and no maternal deaths occurred. No neonatal infection was found from SARS-CoV-2 positive pregnant women. However, there is no sufficient evidence to show that SARS-CoV-2 doesn’t have vertical transmission.
References
Wong C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020 Feb 15;395(10223):470-3.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;95:497-506.
Guan W-j, Ni Z-y, Hu Y, Liang W-h, Ou C-q, He J-x, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708-20.
Johansson MA, Quandelacy TM, Kada S, Prasad PV, Steele M, Brooks JT, et al. SARS-CoV-2 transmission from people without COVID-19 symptoms. JAMA network open. 2021;4(1)
Baggett TP, Keyes H, Sporn N, Gaeta JM. Prevalence of SARS-CoV-2 infection in residents of a large homeless shelter in Boston. Jama. 2020;323(21):2191-2.
Sakurai A, Kato S, Hayashi M, Ishihara T, Iwata M, Morise Z, et al. Natural history of asymptomatic SAR-CoV-2 infection. N Engl J Med 2020;383:885-6.
Chen L, Li Q, Zheng D, Jaing H, Wei Y, Zou L, et al. Clinical characteristics of pregnant women with Covid-19 in Wuhan, China. N Engl J Med 2020;382:e100.
Prabhu M, Cagino K, Matthews KC, Friedlander RL, Glynn SM, Kubiak JM, et al. Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York city: a prospective cohort study. BJOG. 2020 Nov;127(12):1548-56.doi:10.1111/1471-0528.16403.
สถานการณ์การติดเชื้อ COVID 19 ในหญิงตั้งครรภ์ หญิงหลังคลอด 6 สัปดาห์ และทารกแรกเกิดระหว่าง 1 ธันวาคม 2563-16 พฤษภาคม 2564. กรมอนามัย.
Gupta P, Kumar S, Sharma SS. SARS-CoV-2 prevalence and maternal-perinatal outcomes among pregnant women admitted for delivery: Experience from COVID-19-dedicated maternity hospital in Jammu, Jammu and Kashmir (India) J Med Virol. 2021;1-10.
Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical characteristics of Covid-19 in New York City. N Engl J Med 2020;382:2372-4.
Knight M, Bunch K, Vousden N, Morris E, Simpson N, Gale C, et al. Characteristics and outcomes of pregnant women hospitalized with confirmed SARS-CoV-2 infection in the UK: a national cohort study using the UK Obstetric Surveillance System (UKOSS) [Internet]. BMJ 2020;369:m2107. https://doi.org/10.1136/bmj.m2107 [Epub ahead of print].
Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020;370:m3320.
Jafari M, Pormohammad A, Sheikh Neshin SA, et al. Clinical characteristics and outcomes of pregnant women with COVID-19 and comparison with control patients: A systematic review and meta-analysis. Rev Med Virol 2021 Jan 2:e2208. doi: 10.1002/rmv.2208.
Zaigham Ml, Andersson O. Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies. Acta Obstet Gynecon Scand 2020 Apr 7. doi: 10.1111/aogs.13867. [Epub ahead of print].
Fassett MJ, Lurvey LD, Yasumura L, et al. Universal SARS-CoV-2 screening in women admitted for delivery in a large managed care organization. AM J Perinatol 2020;37(11):1110-1114.
Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol 2021;224(1):35-53.e3.
Kompaniyets L, Goodman AB, Belay B, et al. Body Mass Index and Risk for COVID-19-Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death -- United states, March-December 2020.(2021). MMWR Morb Mortal Wkly Rep 2021;70:355-361. DOI: http://dxdoi.org/10.15585/mmwr.mm7010e4
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Region11Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
