The Association between Patient-Related Factors with Seriousness of Adverse Drug
Keywords:
Patient-related factors, Severity, Adverse drug reactionsAbstract
Background: Adverse drug reactions (ADRs) are those that are unintended and harmful to humans when used in normal doses. The severity of ADRs results in hospitalization and lengthening of treatment or may be disabled or even die.
Objectives: To study the relationship between patient-related factors and the severity of ADRs.
Method: It is a retrospective study. Analyze patient-related factors such as gender, age, history of drug/food/chemical allergies. Descriptive statistics were used for the frequency, percentage, and the relationship between the factors related to the patients studied and the severity of the occurrence of ADRs using chi-square statistics.
Results: The results showed that 52.50% were female and 47.50% were male. The age group with the highest ADRs was 51-60 years old 18.20%. Patients had a history of drug/food/chemical allergy 19.90% and no history 80.10%. The drug groups that cause the most ADRs are: Antibacterial drugs 42.10% and other drugs 57.90%. Regarding the seriousness of symptoms, ADRs were found to be serious 22.50% with no seriousness 77.50%. There was a statistically significant difference between the drug group and the ADRs severity (p=0.037 and p<0.001, respectively).
Conclusion: The severity of adverse drug reactions was related to patient age and drug group.
References
ศูนย์เฝ้าระวังความปลอดภัยด้านผลิตภัณฑ์สุขภาพ. รายงานเหตุการณ์ไม่พึงประสงค์จากการใช้ผลิตภัณฑ์สุขภาพในมนุษย์, สืบค้นเมื่อ 4 ธันวาคม 2565. จาก https://hpvcth.fda.moph.go.th/about-us/
บงกช เพียรไทย.. ความสัมพันธ์ระหว่างปัจจัยและระดับความร้ายแรงของเหตุการณ์ไม่พึงประสงค์จากการใช้ยา โรงพยาบาลพระนารายณ์ : การศึกษาภาคตัดขวาง. วารสารสุขภาพและสิ่งแวดล้อมศึกษา, 2563 ;5(2), 135-147.
รุ่งนภา ทรงศิริพันธ์. (2561). ศึกษาปัจจัยที่มีความสัมพันธ์กับระดับความรุนแรงของอาการไม่พึงประสงค์จากการใช้ยา. วารสารเครือข่ายวิทยาลัยพยาบาลและการสาธารณสุขภาคใต้,2561; 5(2), 46-56.
ศิริกัญญา คำพิชิต, ธงชัย ประฎิภาณวัตร และนฤมล เจริญศิริพรกุล. (2561). การศึกษาความรุนแรงของการเกิดอาการไม่พึงประสงค์จากยาโดยการรายงานของผู้ป่วย. ศรีนครินทร์เวชสาร 2561; 33(2), 113-121.
Seon-Heye W, Sang-Yoen S, Eunji Y and Hong-Yup A. Risk Factors Related to Serious Adverse Drug Reactions Reported through Electronic Submission during Hospitalization in Elderly Patients. Korean J Fam Med. 2022 Mar;43(2):125-131.
Yan Z, Feng Z, Jiao Z, Chen C, Wang G, Feng D. The severity of adverse drug reactions and their influencing factors based on the ADR monitoring center of Henan Province. Sci Rep. 2021 Oct 14;11(1):20402. doi: 10.1038/s41598-021-99908-3. Erratum in: Sci Rep. 2022 Feb 8;12(1):2439. PMID: 34650181; PMCID: PMC8516964.
Alomar MJ. Factors affecting the development of adverse drug reactions (Review article). Saudi Pharm J. 2014 Apr;22(2):83-94.
Lavan AH, Gallagher P. Predicting risk of adverse drug reactions in older adults. Therapeutic Advances in Drug Safety. 2016 ;7(1):11-22.
Manoj KM, Yogananda R and Saurabh D. Risk factors associated with adverse reactions in hospitalized patients. IJPSR,; 8(9)2017: 3847-3854.
Jung IY, Kim JJ, Lee SJ, Kim J, Seong H, Jeong W and et al. Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea. BioMed Res Int. 2017;2017:4304973.doi:10.1155/2017/ 4304973.Epub 2017 Dec 31.PMCID : PMC5804292.
Hall V, Wong M, Munsif M, Stevenson BR, Elliott K, Lucas M and et al. Antimicrobial anaphylaxis: the changing face of severe antimicrobial allergy. J Antimicrob Chemother. 2020 Jan 1;75(1):229-235. doi: 10.1093/jac/dkz422. PMID: 31637446.
Patterson RA and Stankewicz HA. Penicillin Allergy. [Updated 2022 Jun 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459320/
Konyoung P, Nakkam N, Khawsuk H, Khaeso K and Tassaneeyakul W. Severe Cutaneous Adverse Drug Reactions: A Study of 216 Patients from Udon Thani Hospital. Thai J Pharmacol ; 2020,42(1) : 5-19.
Kim HK, Kim DY, Bae EK and Kim DW. Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008–2017. J Korean Med Sci. 2020 Feb;35(4):e17. https://doi.org/10.3346/jkms.2020.35.e17
Park CS, Kang DY, Kang MG, Kim S, Ye YM, Kim SH and et al. Korean Registry of Severe Cutaneous Adverse Reactions Consortium. Severe Cutaneous Adverse Reactions to Antiepileptic Drugs: A Nationwide Registry-Based Study in Korea. Allergy Asthma Immunol Res. 2019 Sep;11(5):709-722. https://doi.org/10.4168/aair.2019.11.5.709
Chaikong T, Santimaleeworagun W and Phornprapa N. Rate of Severe Cutaneous Adverse Reactions Due to First Line Anti Tuberculosis Drugs: Health Product Vigilance Center Database; The Food and Drug Administration, Ministry of Public Health. 2019 ; 6(4) : 45-63.
Jin HJ, Kang DY, Nam YH, Ye YM, Koh YI, Hur GY and et al. Korean Severe Cutaneous Adverse Reactions Consortium (KoSCAR). Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients. Allergy Asthma Immunol Res. 2021 Mar;13(2):245-255. doi: 10.4168/aair.2021.13.2.245. PMID: 33474859; PMCID: PMC7840880.
Shin HJ, Chang JS, Kim MS, Koh BG, Park HY, Kim TO and et al. Hypersensitivity reactions to multiple anti-tuberculosis drugs. PLoS One. 2021 Feb 4;16(2):e0246291
Patrizia B, Francesco O, Jesper JN, Roberta Z, Laura M and Theo G . Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study. Front. Allergy, 2022 Dec. Front. Allergy 3:1071807.doi: 10.3389/falgy.2022.1071807
Aun MV , Blanca M, Garro LS, Ribeiro MR, Kalil J, Motta AA and et al. Nonsteroidal Anti-Inflammatory Drugs are Major Causes of Drug-Induced Anaphylaxis. J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):414-20.doi: 10.1016/ j.jaip. 2014.03.014. Epub2014 May 23. PMID:25017529.
Shaikhain T A, Al-Husaynib F, Elder K . (December 20.2019). Ibuprofen-induced Anaphylactic Shock in Adult Saudi Patient. Cureus 11(12):e6425. DOI 10.7759/cureus.6425
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