Dowling-Degos Disease: Case Report and Literature Review
Keywords:
Dowling-Degos disease, reticulate pigmentationAbstract
Dowling-Degos disease (DDD), a rare autosomal dominant inherited genodermatosis, commonly affects post-pubertal individuals by presence of progressive reticulated hyperpigmentation and small hyperkeratotic papules predominantly at flexural area and skin folds. Involvement of face, trunk and extremities has also been reported. We report a case of 65-year-old woman with underlying disease of Schizophrenia, who presented with asymptomatic hyperpigmented lesions on the abdomen, both axilla, inframammary regions and both groins for 20 years. The patient reported having similar cutaneous findings in her mother who had passed away a long time ago. Histopathologic findings revealed digitate downward growth of rete ridges with some horn pseudocysts and basal hyperpigmentation without acantholysis.
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