A Patient with Concurrent Lymphomatoid Papulosis Subtypes C and F, Successfully Treated with Methotrexate


  • Poramin Patthamalai Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • Chutima Rungananchai Bhumibol Adulyadej Hospital, Bangkok, Thailand
  • Manasmon Chairatchaneeboon Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand


Lymphomatoid papulosis, Mixed subtypes, CD30 lymphoproliferative disorders, Primary cutaneous T-cell lymphomas, Methotrexate


Lymphomatoid papulosis (LyP) is a rare subtype of primary cutaneous CD30+ lymphoproliferative disorders, characterized by a chronic, recurrent, asymptomatic, and self-healing papulonodular eruption. LyP is categorized into six major subtypes, composed of A, B, C, D, E, and a subtype with DUSP22-IRF4 rearrangement. Recently, several authors have postulated the uncommon F (follicular) subtype. Patients with different histologic variants as well as mixed variants have been reported to share similar clinical manifestations, course of the disease, and prognosis. We report the first case of LyP with coexisting subtypes C and F.

A 42-year-old Thai man manifested with asymptomatic, self-healing recurrent skin-colored follicular and non-follicular papulonodules on his head and back. Some lesions developed into ulcers. Multiple skin biopsies showed two different patterns that were consistent with LyP subtypes C and F. Systemic staging workups were negative. He responded well to oral low-dose methotrexate. He had a regular follow-up for more than 5 years without evidence of secondary malignancy.


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How to Cite

Patthamalai, P., Rungananchai, C., & Chairatchaneeboon, M. (2023). A Patient with Concurrent Lymphomatoid Papulosis Subtypes C and F, Successfully Treated with Methotrexate. Thai Journal of Dermatology, 39(2), 44–50. Retrieved from https://he02.tci-thaijo.org/index.php/TJD/article/view/261989



Case Report