A Patient with Concurrent Lymphomatoid Papulosis Subtypes C and F, Successfully Treated with Methotrexate
Keywords:
Lymphomatoid papulosis, Mixed subtypes, CD30 lymphoproliferative disorders, Primary cutaneous T-cell lymphomas, MethotrexateAbstract
Lymphomatoid papulosis (LyP) is a rare subtype of primary cutaneous CD30+ lymphoproliferative disorders, characterized by a chronic, recurrent, asymptomatic, and self-healing papulonodular eruption. LyP is categorized into six major subtypes, composed of A, B, C, D, E, and a subtype with DUSP22-IRF4 rearrangement. Recently, several authors have postulated the uncommon F (follicular) subtype. Patients with different histologic variants as well as mixed variants have been reported to share similar clinical manifestations, course of the disease, and prognosis. We report the first case of LyP with coexisting subtypes C and F.
A 42-year-old Thai man manifested with asymptomatic, self-healing recurrent skin-colored follicular and non-follicular papulonodules on his head and back. Some lesions developed into ulcers. Multiple skin biopsies showed two different patterns that were consistent with LyP subtypes C and F. Systemic staging workups were negative. He responded well to oral low-dose methotrexate. He had a regular follow-up for more than 5 years without evidence of secondary malignancy.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรงซึ่งกองบรรณาธิการวารสาร ไม่จำเป็นต้องเห็นด้วย หรือร่วมรับผิดชอบใดๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารโรคผิวหนัง ถือเป็นลิขสิทธิ์ของวารสารฯ หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักอักษรจากบรรณาธิการวารสารโรคผิวหนังก่อนเท่านั้น
