Kaewjongprasit, D Quality of life and kidney function of living kidney donors at the Faculty of Medicine, Chiang Mai University
Keywords:
Kidney transplantation, quality of life, kidney donorsAbstract
Title:
Quality of life and kidney function of living kidney donors at the Faculty of Medicine, Chiang Mai University.
Objective: To compare quality of life, residual kidney function and complications of kidney donors before and after donation in the Faculty of Medicine, Chiang Mai University, Thailand.
Methods: This prospective cohort study included 76 participants who visited the clinic for planning donor nephrectomy and/or routine follow up after donation between November 2015 and June 2017. The primary outcome was the quality of life of living kidney donors after donation in short-term and long-term follow up assessed using the SF-36 questionnaire. The secondary outcome was assessment of residual kidney function after donation. Other potential consequences of kidney donation are also reported on in our study, including hypertension, proteinuria, complications during pregnancy and second thoughts.
Results: Quality of life showed a decline in the early post donation period but gradually improved over time especially as regards physical components. The overall quality of life in kidney donors remained higher than the control general population after donation. Sixty-three donors had a GFR ≥ 60 mL/min/1.73m2 after donation. Eight donors had a GFR of 45-59 mL/min/1.73m2. Five donors did not visit the clinic for routine follow up after donation due to transportation difficulties. No significant proteinuria was detected in our study. Two donors developed hypertension after donation. Two donors became pregnant after donation and underwent successful delivery without complication. One donor regretted their decision because of an early graft loss in her recipient due to renal vein thrombosis.
Conclusion: Donor nephrectomy is recognized as being a safe procedure. A decrease in quality of life after donation was observed only in the early post-donation period. Mental health was not affected by kidney donation. Overall quality of life in kidney donors was higher than in a comparative general population. Residual kidney function after donation was at an acceptable level based on GFR.
Keywords: kidney transplantation, quality of life, kidney donors
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