Feasibility study of relative renal function assessment by contrast-enhanced abdominal CT in comparison to 99mTc-MAG3 renal scintigraphy
Objective: To determine the feasibility of using contrast-enhanced abdominal CT to assess relative renal function.
Materials and Methods: This retrospective study reviewed data from 32 patients who had had investigations by contrast-enhanced abdominal CT and 99mTc-MAG3 renal scintigraphy, within a period of not more than 30 days. Post-processing CT images of kidneys were by manual segmentation and calculated to interpret the relative renal function.
Results: There was strong correlation between CT derived relative renal function and 99mTc-MAG3 renal scintigraphy (r = 0.971, p < 0.001) and no statistically significant difference in renal function between the two techniques (p = 0.572).
Conclusion: Contrast-enhanced abdominal CT can determine relative renal function as accurately as renal scintigraphy. It is an appropriate alternative method, especially in hospitals where renal scintigraphy is not available.
Habbous S, Garcia-Ochoa C, Brahm G, Nguan C, Garg AX. Can Split Renal Volume Assessment by Computed Tomography Replace Nuclear Split Renal Function in Living Kidney Donor Evaluations? A Systematic Review and Meta-Analysis. Can J Kidney Heal Dis 2019;88:1-15.
Helck A, Schonermarck U, Habicht A, Notohamiprodjo M, Stangl M, Klotz E, et al. Determination of split renal function using dynamic CT-angiography: Preliminary results. PLoS One 2014;9:e91774.
Hamed MAE. New advances in assessment of the individual renal function in chronic unilateral renal obstruction using functional CT compared to 99m Tc-DTPA renal scan. Nucl Med Rev 2014;17:59-64.
Björkman H. Alternative Methods for Assessment of Split Renal Function. Uppsala: Uppsala University; 2008.
Wolf GL. Using enhanced computed tomography to measure renal function and fractional vascular volume. Am J Kidney Dis 1999;33:804-6.
Yuan X, Zhang J, Tang K, Quan C, Tian Y, Li H, et al. Determination of Glomerular Filtration Rate with CT Measurement of Renal Clearance of Iodinated Contrast Dynamic Imaging “Gates” Method: A Validation Study in Asymmetrical Renal Disease. Radiology 2017;282:552-60.
Nilsson H, Wadstrom J, Andersson LG, Raland H, Magnusson A. Measuring split renal function in renal donors: Can computed tomography replace renography? Acta radiol 2004;45:474-80.
Fowler JC, Beadsmoore C, Gaskarth MTG, Cheow HK, Hegarty P, Bullock KN, et al. A simple processing method allowing comparison of renal enhancing volumes derived from standard protal venous phase contrast-enhanced mutidetector CT images to derive a CT estimate of differential renal function with equivalent results to nuclear medicine quantification. Br J Radiol 2006;79:935-42.
Frennby B, Almen T, Lijia B, Eriksson LG, Hellsten S, Lindblad B, et al. Determination of the relative glomerular filtration rate of each kidney in Man. Comparison between iohexol CT and 99mTc-DTPA scintigraphy. Acta radiol 1995;36:410-17.
El-Diasty MT, Gaballa G, Gad HM, Borg MA, Abou-Elghar ME, Sheir KZ, et al. Evaluation of CT perfusion parameters for assessment of split renal function in healthy donors. Egypt J Radiol Nucl Med 2016;47:1681-8.
Koushanpour E, Kriz W. Formation of Glomerular Ultrafiltrate. In: Koushanpour E, Kriz W, editors. Renal Physiology. New York: Springer;1986. p. 53-72.
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