The Incidental prostatic adenocarcinoma and transitional cell carcinoma involvement of the prostate gland in patients undergoing radical cystoprostatectomy for bladder cancer treatment in Rajavithi Hospital

Authors

  • Weerawut Promwattanapan Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Nattapong Wongwattanasatien Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand

DOI:

https://doi.org/10.52786/isu.a.31

Keywords:

Incidental prostate cancer, radical cystoprostatectomy, transitional cell carcinoma involvement of the prostate gland

Abstract

Objective: To determine the incidence of incidental prostatic adenocarcinoma and transitional cell carcinoma (TCC) involvement of the prostate gland in patients undergoing radical cystoprostatectomy in Rajavithi Hospital, Secondly, to assess the possible influence of the patient factors and bladder cancer on the pathological findings of the prostate gland.

Materials and Methods: We retrospectively reviewed 169 male patients who had undergone radical cystoprostatectomy for bladder cancer between April 2013 and August 2019. Pathologic findings of the prostate gland and urothelial cancer in the prostate gland were catalogued. Information including age, body mass index (BMI), underlying disease, glomerular filtration rate (GFR), pathologic stage, and grade was collected and analyzed to determine any correlations.

Results: Incidental prostatic adenocarcinoma and TCC involvement of the prostate gland were found in 15 patients (8.9%) and 29 patients (17.2%), respectively. There were no correlations between patient demographics and pathological findings of the prostate gland.

Conclusion: Although the incidence of incidental prostatic adenocarcinoma and TCC involvement of the prostate gland in our research is low, the screening of every candidate for prostate sparing cystectomy with a digital rectal examination, prostate-specific antigen, and transurethral biopsy of the prostatic urethra and bladder neck prior to surgery are recommended.

References

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209-49.

Witjes JA, Comperat E, Cowan NC, De Santis M, Gakis G, Lebret T, et al. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol 2014;65:778-92.

Suriyawongkul S, Gosrisirikul C, Choonhaklai V, Thaidumrong T, Pumpaisanchai S, Wongwattanasatien N, et al. Renal function of bladder cancer patients after urinary diversion by ileal conduit in Rajavithi Hospital. Insight Urol 2021;42:34-9.

Morganstern BA, Bochner B, Dalbagni G, Shabsigh A, Rapkin B. The psychological context of quality of life: a psychometric analysis of a novel idiographic measure of bladder cancer patients’ personal goals and concerns prior to surgery. Health Qual Life Outcomes 2011;9:10.

Stenzl A, Sherif H, Kuczyk M. Radical cystectomy with orthotopic neobladder for invasive bladder cancer: a critical analysis of long term oncological, functional and quality of life results. Int Braz J Urol 2010;36:537-47.

Macek P, Sanchez-Salas R, Rozet F, Barret E, Galiano B, Hanus T, et al. Prostate-sparing radical cystectomy for selected patients with bladder cancer. Urol Int 2013;91:89-96.

Gakis G, Schilling D, Bedke J, Sievert KD, Stenzl A. Incidental prostate cancer at radical cystoprostatectomy: implications for apex-sparing surgery. BJU Int 2010;105:468-71.

Kurahashi T, Miyake H, Furukawa J, Kumano M, Takenaka A, Fujisawa M. Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer. Int Urol Nephrol 2010;42:73-9.

Heidegger I, Oberaigner W, Horninger W, Picher R. High incidence of clinically significant concomitant prostate cancer in patients undergoing radical cystectomy for bladder cancer: a 10-year single-center experience. Urol Oncol 2017;35:152.e1-5.

Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29.

Baade PD, Youlden DR, Cramb SM, Dunn J, Gardiner RA. Epidemiology of prostate cancer in the Asia-Pacific region. Prostate Int 2013;1:47-58.

Pu YS, Chiang HS, Lin CC, Huang CY, Huang KH, Chen J. Changing trends of prostate cancer in Asia. Aging Male 2004;7:120-32.

Baade PD, Youlden DR, Krnjacki LJ. International epidemiology of prostate cancer: Geographical distribution and secular trends. Mol Nutr Food Res 2009;53:171-84.

Romero FR, de Castro MG, Andriolo Júnior A, de Meneses AH, Fernandes RC, Perez MD. Coexistence of prostate neoplasia in patients undergoing radical cystoprostatectomy due to vesical neoplasia. Int Braz J Urol 2004;30:296-301.

Pettus JA, Al-Ahmadie H, Barocas DA, Koppie TM, Herr H, Donat SM, et al. Risk assessment of prostatic pathology in patients undergoing radical cystoprostatectomy. Eur Urol 2008;53:370-5.

Abdelhady M, Abusamra A, Pautler SE, Chin JL, Izawa JI. Clinically significant prostate cancer found incidentally in radical cystoprostatectomy specimens. BJU Int 2007;99:326-9.

Dembowski J, Hackemer P, Winkler A, Otlewska A, Tupikowski K, Zdrojowy R. Prostate and Bladder Cancer Coexistence in Patients Undergoing Radical Cystoprostatectomy. Adv Clin Exp Med 2015;24:657-62.

Sanli O, Acar O, Celtik M, Oktar T, Kilicaraslan I, Ozcan F, et al. Should prostate cancer status be determined in patients undergoing radical cysto- prostatectomy? Urol Int 2006;77:307-10.

Tanaka T, Koie T, Ohyama C, Hashimoto Y, Imai A, Tobisawa Y, et al. Incidental prostate cancer in patients with muscle-invasive bladder cancer who underwent radical cystoprostatectomy. Jpn J Clin Oncol 2017;47:1078-82.

Yang X,Monn MF,Liu L,Liu Y, Su J, Lyu T, et al. Incidental prostate cancer in Asian men: high prevalence of incidental prostatic adenocarcinoma in Chinese patients undergoing radical cystoprostatectomy for treatment of bladder cancer and selection of candidates for prostate-sparing cystectomy. Prostate 2015;75:845-54.

Tang S, Hao H, Fang D, Zheng W, Ge P, Su X, et al. Prostate cancer incidentally discovered at the time of radical cystoprostatectomy does not decrease overall survival: Results from a large Chinese medical center. Int Braz J Urol 2018;44:258-66.

Ram D, Rajappa SK, Rawal S, Singh A, Sharma KC, Dewan AK. Clinical Significance of Incidental Prostatic Carcinoma on Radical Cystectomy Histology Specimens: a Clinicopathological and Survival Analysis. Indian J Surg Oncol 2018;9:192-8.

Ayyathurai R, Gomez P, Luongo T, Soloway MS, Manoharan M. Prostatic involvement by urothelial carcinoma of the bladder: clinicopathological features and outcome after radical cystectomy. BJU Int 2007;100:1021-5.

Revelo MP, Cookson MS, Chang SS, Shook MF, Smith JA Jr, Shappell SB. Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible

apical sparing surgery. J Urol 2004;171:646-51.

Richards KA, Parks GE, Badlani GH, Kader AK, Hemal AK, Pettus JA. Developing selection criteria for prostate-sparing cystectomy: a review of cystoprostatectomy specimens. Urology 2010;75:1116-20.

Tabibi A, Simforoosh N, Parvin M, Abdi H, Java-herforooshzadeh A, Farrokhi F, et al. Predictive factors for prostatic involvement by transitional cell carcinoma of the bladder. Urol J 2011;8:43-7.

Guzzo TJ, Vaughn DJ. Management of Metastatic and Invasive Bladder Cancer. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, editors. Campbell-Walsh Urology. 11th ed. Philadelphia: Elsevier; 2015. p. 2226.

Downloads

Published

2021-11-30

How to Cite

Promwattanapan, W., & Wongwattanasatien, N. (2021). The Incidental prostatic adenocarcinoma and transitional cell carcinoma involvement of the prostate gland in patients undergoing radical cystoprostatectomy for bladder cancer treatment in Rajavithi Hospital. Insight Urology, 42(2), 103–109. https://doi.org/10.52786/isu.a.31

Issue

Section

Original article