Oncological outcomes of metastatic castration resistant prostate cancer (mCRPC) treated with different therapies sequences after completion of docetaxel: a retrospective study in Songklanagarind Hospital

Authors

  • Isaris Chaokhamin Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkhla University, Hatyai, Songkhla, Thailand
  • Worapat Attawettayanon Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkhla University, Hatyai, Songkhla, Thailand
  • Virote Chalieopanyarwong Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkhla University, Hatyai, Songkhla, Thailand
  • Monthira Tanthanuch Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkhla University, Hatyai, Songkhla, Thailand
  • Tanan Bejrananda Division of Urology, Department of Surgery, Faculty of Medicine, Prince of Songkhla University, Hatyai, Songkhla, Thailand

DOI:

https://doi.org/10.52786/isu.a.35

Keywords:

Metastatic castration-resistant prostate cancer, abiraterone acetate, enzalutamide, cabazetaxel, ketoconazole, overall survival

Abstract

Objective: Many treatment options of metastatic castration-resistant prostate cancer (mCRPC) after docetaxel chemotherapy have proved efficacious in clinical trials but, to date, knowledge regarding oncological outcomes is limited.

Materials and Methods: We assessed the oncological outcome of 4 drugs (abi- raterone acetate, cabazetaxel, enzalutamide and ketoconazole) in a normal clinical setting in a university-based hospital. Our cohort consisted of 69 patients with post-docetaxel mCRPC. The primary endpoint was overall survival (OS). The secondary endpoint was predicted factor associated overall survival with all sec- ond-line mCRPC treatment outcomes according to the Cox proportional hazards regression model.

Results: This cohort consisted of 69 patients with progressive mCRPC after docetaxel chemotherapy. Median overall survival following treatment with abiraterone acetate and ketoconazole was 25.92 and 9.59 months respectively (p < 0.05). Overall survival rates at 1-year following abiraterone acetate, cabazetaxel, enzalutamide and ketoconazole therapy were 76.3%, 83.3%, 100% and 41.9%, respectively. Multivariable analysis found that abiraterone acetate, cabazitaxel and enzalutamide significantly improved survival in comparison to ketoconazole (p < 0.001).

Conclusion: Analysis of overall survival following second-line treatment of mCRPC post docetaxel in our study statistically significantly confirmed that abiraterone acetate, cabazitaxel and enzalutamide improve overall survival in comparison to ketoconazole. The study also found that enzalutamide treatment resulted in better outcomes in comparison to the other drugs.

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References

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Published

2021-11-30

How to Cite

Chaokhamin, I., Attawettayanon, W. ., Chalieopanyarwong, V. . ., Tanthanuch , M., & Bejrananda, T. (2021). Oncological outcomes of metastatic castration resistant prostate cancer (mCRPC) treated with different therapies sequences after completion of docetaxel: a retrospective study in Songklanagarind Hospital. Insight Urology, 42(2), 131–137. https://doi.org/10.52786/isu.a.35

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Original article