The Association of Bacillus Calmette-Guerin Instillation Therapy Side Effects for Non Muscle-Invasive Bladder Cancer and Its Therapeutic Efficacy
Keywords:
Bacillus Calmette-Guerin, instillation therapy, side effects, non muscle-invasive, bladder cancerAbstract
Objectives: To investigate the relation between side effects of intravesical Bacillus Calmette-Guerin (BCG) therapy and its therapeutic efficacy.
Methods: Non-muscle invasive bladder cancer patients in Phramongkutklao hospital between 2002 and 2006 who were treated with Transurethral resection of bladder tumor (TUR-BT) and intravesical instillation of BCG (completion of at least 6 times of weekly induction after TUR-BT) were analyzed. Their medical records, pathological reports and treatment protocols were reviewed retrospectively. The association between the occurrence of side effects of Bacillus Calmette-Guerin (BCG) therapy and tumor recurrence or tumor progression were analyzed.
Results: BCG side effects were occurred in 74.5% of patients. In patients with side effects, tumor recurrence was 35.6% and tumor progression was 7%.In patient without side effects, tumor recurrence was 28% and tumor progression was 20%.The occurrence of side effects was not associated with tumor recurrence and tumor progression (p-value 0.595, 0.190 respectively).
Conclusions: While a correlation between BCG side effect and efficacy exists, this study does not confirm that BCG side effect is actually responsible for an improved outcome.
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