Pathologic Diagnosis of Prostatic Adenocarcinoma
Keywords:
Pathologic, Diagnosis, Prostatic, AdenocarcinomaAbstract
Prostatic adenocarcinoma is the most common malignancy in men in the United States and is the second most common cause of cancer death following lung cancer.[1] It was estimated that approximately 28,660 American men died of this tumor in 2008, while 186,320 new cases were detected.[2] In Thailand, it is among the three most common malignancies in male with an estimated incidence rate as high as 4.9 per 100,000.[3] It is now the most common cancer in men in Siriraj Hos-pital.[4] Latent prostate cancer incidentally found at the time of autopsy is also high, up to 80 % by age 80 years.[5]
Pathologically, the diagnosis of prostatic adenocarcinoma requires a combination of architectural, cytologic, and ancillary findings.[1,6] In the past, the prostate was divided into 5 lobes namely, anterior, middle, posterior, and 2 lateral lobes.[7] In 1988 McNeal introduced a different anatomic division. He devided the prostate into zones, namely peripheral zone (TZ), central zone and transition zone,[8] which was subsequently globally accepted since this zoning correlated better with the deseases of the prostate. The peripheral zone accounts approximately for 65% of normal prostatic volume and is prone to the development of inflammation and adenocar-cinoma,[9,10] while transition zone is responsible for the development of benign prostatic hyperplasia (nodular hyperplasia).[11]
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