Progression of Prostate Cancer after Brachytherapy, Categorized by Risk groups


  • Yossak Sakulchaiyakorn Phramongkutklao Hospital


Progression, Prostate Cancer, Brachytherapy, Categorized, Risk groups


Objective: To study the progression of prostate cancer after Brachytherapy in Phramongkutklao Hospital by using PSA as a surrogate of outcome. Using PSA to calculate for BRFS (Biochemical Relapse free Survival) and % free from PSA failure. This study also studied the side effects, complication and Quality of life after Brachytherapy.

Group and Methods: Localized prostate cancer patient in Phramongkutklao hospital for 78 patients, since December 2000 until October 2008 were categorized by DûAmico (1998) risk group to 3 groups. In low and Intermediate risk patients were treated mostly with Brachytherapy alone. In high risk group patients usually were treated by combination therapy which are external beam radiation and androgen deprivation therapy for a period of time.

Outcome: Longest follow up of the patient was almost 8 years and the average follow up time was 4.2 years. The results were satisfactory. BRFS by risk group:low, intermediate and high risk were 100%, 96% and 93.3% respectively. %Free from PSA failure by initial PSA: <10, 10-20, >20 were 93.8%, 92.3%, 84.8% respectively. The study showed that risk group affects the outcome significantly (P value=0.001) Most side effects were lower urinary tract symptoms which are controlled by medication but some (14% of severe LUTS patients) were needed to TUR-P. Serious complication, such as prostatorectal fistula was not seen.

Conclusion: Brachytherapy is the suitable choice of treatment in localized prostate cancer with satisfactory outcome and low side effects and complications. However this study is quite small and short term study when compared to the 15 years follow up study in US. But it is Perhaps the beginning of study in the outcome of Brachytherapy in Thailand. The Author hopes that there will be larger and more accurate study in Thailand.


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How to Cite

Sakulchaiyakorn, Y. (2009). Progression of Prostate Cancer after Brachytherapy, Categorized by Risk groups. Insight Urology, 30(2), 59–67. Retrieved from



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