The Study of Serum Testosterone Level and Aging Male Symptoms in Thai Aging Male with Erectile Dysfunction
Keywords:
Serum Testosterone, Aging Male Symptoms, Thai Aging Male, Erectile DysfunctionAbstract
Purpose: To study the relationship between age, serum testosterone levels and aging male symp- toms in Thai aging male with erectile dysfunction.
Materials and Methods: In all 51 men above the age of 40 years with erectile dysfunction, selected from andropause clinic outpatient department, King Chulalongkorn memorial hospital, with physical exa- mination and completed questionnaire about personal detail, question, Aging male symptom scale (Thai version) and complete data on serum total testosterone, free testosterone, bioavialable testosterone, sex hormone-binding globulin level.
Results: Mean age of samples was 59.6 (SD = 9.4). Mean value of total, free testosterone bioavailable testosterone and sex hormone binding globulin (SHBG) was 453.7 ng/dl, 8.7 ng/dl, 208.4 ng/dl and 38 nmol respectively. Approximately 11.8% of subject had low total testosterone (total testosterone <300 ng/ dl), but none subject had low free testosterone (free testosterone <5 ng/dl). The results of the AMS scores mostly suggested moderate symptoms (41.2%). AMS scale and three subgroup AMS domain scale was not significantly correlated with testosterone, free testosterone or bioavailable testosterone. Only age was significantly correlated with sex hormone binding globulin.
Conclusions: AMS scale was not correlated with age and serum testosterone level in Thai aging male with erectile dysfunction. Also, the fact that aging male symptoms questionnaires cannot predict androgen levels and does not exclude the possibility that relative androgen deficiency may contribute to the multifactorially defined clinical changes in aging men with erectile dysfunction.
References
Swerdlof RS, Wang C. Androgens and the ageing male. Best Practice & Research Clinical Endocrinology & Metabolism 2004; 18(3): 349-62.
Gore J. The Role of Serum TestosteroneTesting: Routine Hormone Analysis Is an Essential Part of the InitialScreening of Men With Erectile Dysfunction. MedReviews, LIC 2004; 6(4): 207-10.
Glina S. Testosterone and erectile dysfunction. JMHG 2004; 1(4) :407-12.
Wagner G, Mulhall J. Pathophysiology and diagnosis of male erectile dysfunction. BJU International 2001; 88(3): 3-10.
Daig I, Heinemann LA, Kim S, et al. The Aging Maleûs Symptom (AMS) scale: review of it methodological characteristic. Health and Quality of Life Outcome 2003; 1: 1-12.
Barsar MM, Aydin G, Mert C, Keles I, Caglayan O, Orkun S et al. Relationship between sex steroids and Aging male symtoms score and International index of erectile function. Urology 2005; 66(3): 597-601.
Hwang TI, Lo HC, Tsai TF, Chiou HY. Association among hypogonadism, quality of life and erectile dysfunction in middle-aged and aged male in Taiwan. International Journal of Impotence Research 2007; 19(1): 69.
Raboch J, Pietrucha S, Raboch J. Serum testosterone level and coital activity in men with somatosexual disorders. Neuroendo- crinology Latter 2003; 5(24): 321-4.
Guay A. Review: testosterone and erectile physiology. The Aging Male 2006;9(4):201-6.
Fahmy AK, Mitra S, Blacklock ARE, Desai KM. Is the measurement of serum testosterone rountinely indicated in men with erectile dysfunction ?. BJU International 1999; 84: 482-4.
Rjifer J. Relationship between testosterone and erectile dysfunction. The Aging Male : Review in Urology. 2000:122-8
Ponholzer A, Plas E, Schatzl G, Brossner C, Mock K, Rauchenwald M, Madersbaccher S. Relationship between testosterone serum level and lifestyle in aging men. The Aging Male 2005; 8(3/4): 190-3.
Beutel ME, Wiltink J, Hauck EW. Correlations between Hormones, Physical, and Aeffective Parameters in Aging Urologic Outpateints. European Urology 2005; 47: 749-55.
Sjoen GT, Goemaere S, De Meyere M, Kaufman JK. Perception of malesû aging symptoms, health and well-being in elderly community-dwelling men is not related to circulating androgen levels. Psychoneuroendocrinology 2004; 29: 201-14.
Heinemann LA, Saad F, Heinemann K, Thai DM. Can result of the Aging Maleûs Symptom (AMS) scale predicts those of screening scales for androgen deficiency?. Health and Quality of Life Outcome 2004; 7(3): 211-18.
Diag I, Heinemann LA, Kim s, Leungwattanakit S, Badia X, Myoy E, Moore C, Saad F, Potthoff D, Thai DM. The Aging Male SymptomS (AMS) scale : Review of its methodological characteristic. Health and Quality of Life Outcome 2003; 1: 1-77.
Rucklinger E, Metka M, Huber J. Hormone profile, Body Mass Index and Aging Male Symptoms- result of the Androx Vienna Municipality study. The Aging Male 2005; 7: 188-96.
Marales A, Lunenfeld B. Investigation, treatment and monitoring of late-onset hypogonadodism in males. The Aging Male 2002; 5: 74-86.
Becker AJ, Uckert S, Stief CG, Scheller F, Knapp WH, Hartmann U, et al. Serum level of humen growth hormone during different penile condition in the cavernous and systemic blood of healthy men and patients with erectile dysfunction. Urology 2002; 59(4): 609-14.
Araujo AB, Esche GR, Kupelian V, et al. Prevalence of Symptomatic Androgen Deficiency in men. The Endocrine Society 2007; July 31.
Martinez- Jabaloyas JM, Queipo- Zaraoza A, Pastor- Hernandez F, Gil- Salom M, Chuan- Neuz P. Testosterone levels in men with erectile dysfunction. BJU 2006; 97: 1278- 83.
Green JS, Holden ST, Ingram P, Bose P, Grorge DP, Bowsher WG. An investigate of erectile dysfunction in Gwent, Wales. BJU International 2001; 88: 551-3.
Mikhail N. Does Testosterone Have a Role in Erectile Function ?. AJM 2006; 119: 373-82.
