Nocturia and Efficacy of Desmopressin for Treatment of Polyuric Nocturia
Keywords:
Nocturia, Desmopressin, Polyuric NocturiaAbstract
Objective: To investigate incidence of polyuric nocturia in nocturia patient and efiicacy, the effect on quality of life, safety of Desmopressin in treatment of polyuric nocturia.
Patients and Methods: Total 34 patients who were verified nocturia which 15 patients were diag- nosed polyuric nocturia were recruited .Average age was 67.87 year (range 60-80 years) Desmopressin (0.1 mg) was given to the patients who was diagnosed polyuric nocturia for 4 weeks. After 2, 4 weeks these people were collected symptom by frequency/volume chart and quality of life by Kingûs Health Questionnaire, General Health questionnaire and blood for electrolyte.
Results: Fifteen patients of 34 patients were diagnosed polyuric nocturia (44%). On the average, frequency of nocturnal void decreased from 2.73+0.34 to 1.6+0.64 at 2 wks and 1.68+0.43 at 4 wks (p=0.002) and nocturnal void volume decreased from 437.39+157. 14 ml to 255.74+136. 18 ml at 2 wks and 251.87+127. 97 ml at 4 wks (p=0.001). The scores of KHQ questionnaire and General Health questionnaire were improved after 4 weeks of Desmopressin. Most adverse events were mild. Serum sodium were >130 mmol/l in 14 patients but one <130 mmol/L at 2 wk follow up. No significant symptom of hyponatremia was shown.
Conclusion: Polyuric nocturia is major cause of nocturia. Oral Desmopressin is effective and well tolerated in treatment of polyuric nocturia patients.
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