Efficacy of Orthosiphon aristatus (Cat’s Whiskers) and an alpha-blocker for stone expulsion in patients with urinary tract calculi undergoing extra corporal shockwave lithotripsy
DOI:
https://doi.org/10.52786/isu.a.92Keywords:
Extra corporal shockwave lithotripsy, ESWL, treatment success rate, Orthosiphion aristatus, alpha-blockersAbstract
Objective: To evaluate the efficacy of a herbal treatment, Orthosiphon aristatus (Cat’s Whiskers) and alpha blockers with regard to stone free and treatment success rates in patients with urinary tract calculi undergoing extra corporal shockwave lithotripsy (ESWL).
Materials and Methods: Data pertinent to 84 patients who underwent ESWL for treatment of KUB stones were prospectively analyzed. Patients were randomized into two groups: Group 1: patients received the medicinal herb Orthosiphon arista- tus post ESWL and Group 2: patients received an alpha-blocker (Doxazocin 2 mg) post ESWL. Both groups used the same medication throughout the 3-month period of the study. All patients were followed-up every 2 weeks after ESWL for 3 months with x-ray and blood tests and urine tests to evaluate results and complications.
Results: The stone free rate was 47.6% in the medical herb Orthosiphon aristatus group and 45.2% in the alpha-blocker group. Treatment success rates were 69.0% in the Orthosiphon aristatus group and 54.8% for alpha-blockers group. The differences in stone free rate and treatment success rate were not statistically significantly different (p = 0.827, 0.261) and the rate of complications in the Orthosiphon aristatus group was not statistically significantly different from the other group (p = 1.000)
Conclusion: Treatment with Orthosiphion aristatus medical expulsive therapy after ESWL give similar results of stone free rate as the group taking alpha-blockers. Both treatments are equally safe methods of medical expulsive therapy.
References
Chaussy C, Brendel W, Schmiedt E. Extracorporeal induced destruction of kidney stones by shock waves. Lancet 1980;2:1265-8.
Donaldson JF, Lardas M, Scrimgeour D, Stewart F, MacLennan S, Lam TB, et al. Systematic review and meta-analysis of the clinical effectiveness of shock wave lithotripsy, retrograde intrarenal surgery, and percutaneous nephrolithotomy for lower-pole renal stones. Eur Urol 2015;67:612-6.
Abe T, Akakura K, Kawaguchi M, Ueda T, Ichikawa T, Ito H, et al. Outcomes of shockwave lithotripsy for upper urinary-tract stones: a large-scale study at a single institution. J Endourol 2005;19:768-73.
Al-Dabbagh AA. Extracorporeal shock wave lithotripsy for the treatment of urolithiasis. Med J Babylon 2009;6:263-7.
Albala DM, Assimos DG, Clayman RV, Denstedt JD, Grasso M, Gutierrez-Aceves J, et al. Lower pole I: a prospective randomized trial of extracorporeal shock wave lithotripsy and percutaneous nephrolithotomy for lower pole nephrolithiasis-initial results. J Urol 2001;166:2072-80.
Turk CH, Knoll T. Petrik A, Sarica K, Seitz, Straub M, et al. Guidelines on urolithiasis: J Urol 2007;178:2418-34.
Perks AE, Schuler TD, Lee J, Ghiculete D, Chung DG, D’A Honey RJ, et al. Stone attenuation and skin-to-stone distance on computed tomography predicts for stone fragmentation by shock wave lithotripsy. Urology 2008;72:765-9.
Abdel-Khalek M, Sheir KZ, Mokhtar AA, Eraky I, Kenawy M, Bazeed M. Prediction of success rate after extracorporeal shock-wave lithotripsy of renal stones–a multivariate analysis model. Scand J Urol Nephrol 2004;38:161-7.
Al-Ansari A, As-Sadiq K, Al-Said S, Younis N, Jaleel OA, Shokeir AA. Prognostic factors of success of extracorporeal shock wave lithotripsy (ESWL) in the treatment of renal stones. Int Urol Nephrol 2006;38:63-7.
Choi JW, Song PH, Kim HT. Predictive factors of the outcome of extracorporeal shockwave lithotripsy for ureteral stones. Korean J Urol 2012;53:424-30.
Tarawneh E, Awad Z, Hani A, Haroun AA, Hadidy A, Mahafza W, et al. Factors affecting urinary calculi treatment by extracorporeal shock wave lithotripsy. Saudi J Kidney Dis Transpl 2010;21:660-5.
Takahara K, Ibuki N, Inamoto T, Nomi H, Ubai T, Azuma H. Predictors of success for stone fragmentation and stone-free rate after extracorporeal shockwave lithotripsy in the treatment of upper urinary tract stones. Urol J 2012;9:549-52.
Shinde S, Balushi Y A,Hossny M, Jose S, Busaidy. Factor affecting the outcome of extracorporeal shockwave lithotripsy in urinary stone treatment. Oman Med J 2018;33:209-17
Cheewaisrakul P. A comparison of stone free rate between a diuretic and a control group of patients undergoing extracorporeal shock wave lithotripsy: a prospective, randomized, double-blind, placebo-controlled trial. Insight Urol 2021;42:138-43.
Tiselius HG, Ackermann D, Alken P, Buck C, Conort P, Gallucci M, et al. Guidelines on urolithiasis. Eur Urol 2001;40:362-71.
Patel T, Kozakowski K, Hruby G, Gupta M. Skin to stone distance is an independent predictor of stone-free status following shockwave lithotripsy. J Endourol 2009;23:1383-5.
Jeong US, Lee S, Kang J, Han DH, Park KH, Baek M. Factors affecting the outcome of extracorporeal shock wave lithotripsy for unilateral urinary stones in children: a 17-year single-institute experience. Korean J Urol 2013;54:460-6.
Tubsaeng P, Srisarakham P, Nueaiytong K. Treatment outcomes and factors affecting the success of extracorporeal shockwave lithotripsy in urinary stone treatment: a study of ten years of data from Mahasarakham Hospital. Insight Urol 2022;43:33-40.
Muang Man W, Ned Noi P. Bai Payapmek or Cat’s Mustache Grass is used to prevent kidney stones. Collection of research results of the project to develop the use of herbs and clinical Thai medicine (1982-1993), 1993. p. 227-23.
Muangman V, Viseshsindh V, Ratana-Olarn K, Buadilok S. The usage of Andrographis paniculata following extracorporeal shock wave lithotripsy (ESWL). J Med Assoc Thai 1995;78:310-3.
Premgamone A, Sriboonlue P, Disatapornjaroen W, Maskasem S, Sinsupan N, Apinives C. A long-term study on the efficacy of a herbal plant, Orthosiphon grandiflorus, and sodium potassium citrate in renal calculi treatment. Southeast Asian J Trop Med Public Health 2001;32:654-60.
Yuliana ND, Khatib A, Link-Struensee AM, Ijzer- man AP, Rungkat-Zakaria F, Choi YH, et al. Ad- enosine A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus. Planta Med 2009;75:132-6.
Modlinger PS, Welch WJ. Adenosine A1 receptor antagonists and the kidney. Curr Opin Nephrol Hypertens 2003;12:497-502.
Poulsen SA, Quinn RJ. Adenosine receptors: new opportunities for future drugs. Bioorg Med Chem 1998;6:619-41.25. Oestreich MC, Vernooij RWM, Sathianathen NJ, Hwang EC, Kuntz GM, Koziarz A, et al. Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults. Cochrane Database Syst Rev 2020;11:CD013393.
Brain E, Geraghty RM, Tzelves L, Mourmouris P, Chatzikrachtis N, Karavitakis M, et al. Outcomes of alpha-blockers as medical expulsive therapy following shockwave lithotripsy: a systematic review and meta-analysis. BJU Int 2023;131:424-33.
Crum LA. Cavitation microjets as a contributory mechanism for renal calculi disintegration in ESWL.
J Urol 1988;140:1587-90.
Al-Ansari A, As-Sadiq K, Al-Said S, Younis N, Jaleel OA, Shokeir AA. Prognostic factors of success of extracorporeal shock wave lithotripsy (ESWL) in the treatment of renal stones. Int Urol Nephrol 2006;38:63-7
Muangman V, Viseshsindh V, Ratana-Olarn K, Buadilok S. The usage of Andrographis paniculata following extracorporeal shock wave lithotripsy (ESWL). J Med Assoc Thai 1995;78:310-3.
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