Ofloxacin prophylaxis can reduce bacteriuria in patients with sterile urine who underwent extracorporeal shockwave lithotripsy (ESWL) for treatment of upper urinary tract stone: a randomized controlled trial
DOI:
https://doi.org/10.52786/isu.a.103Keywords:
ESWL, antibiotic prophylaxis, ofloxacin, bacteriuria, pyuria, sterile urineAbstract
Objective: Urinary tract infections (UTI) are a serious complication in patients undergoing extracorporeal shock wave lithotripsy (ESWL). While antibiotic prophylaxis has proven beneficial in various surgical procedures, this study aimed to evaluate its benefits in ESWL patients with sterile urine.
Materials and Methods: This double-blind, randomized clinical trial was conducted in patients with upper urinary tract stones admitted for ESWL at Sunpasitthiprasong Hospital, Thailand. Patients were randomly assigned to receive either ofloxacin (200 mg) or placebo one hour before ESWL. The incidence of UTI, bacteriuria, pyuria, and patient characteristics including gender, age, underlying conditions, and stone location were assessed in both groups.
Results: Data were collected from a total of 598 patients who were admitted for ESWL between 2008 and 2015. No cases of UTI were observed, and the incidence of pyuria did not differ significantly between the two groups (p = 0.399). However, bacteriuria was found in 11 patients, with 2 (0.60%) in the antibiotic group (n = 310) and 9 (3.10%) in the placebo group (n = 286), showing a statistically significant difference (p = 0.023).
Conclusions: Ofloxacin prophylaxis in sterile urine ESWL patients showed a benefit in reducing the incidence of bacteriuria but incidence of UTI and pyuria showed no change.
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