Factors Influencing Pregnancy rate in Intrauterine Insemination among Infertile Couple: A Study in the Fertility Center, Thammasat University Hospital
Keywords:
intrauterine insemination, pregnancy rate, infertileAbstract
Background: Artificial intrauterine insemination (IUI) is the first method to treat infertility in which the married couple is interested because it is uncomplicated, inexpensive and also has less complications method when compared to the In Vitro Fertilization. However, its clinical pregnancy rate (CPR) is only 5-10 percent and there are many influencing factors effecting to its success. Previous researcher show conflicting data about these facts.
Objective:To determine factors influencing the clinical pregnancy rate of the artificial
insemination in fertility treatment.
Methodology: A retrospective cohort study was conducted at Thammasat Fertility Center from 2017 to 2018. Qualitative data were compared using Chi-square test or Likelihood Ratio when available, and quantitative data were compared using parametric (t-test) or nonparametric (Mann-Whitney) tests as appropriate. A multiple regression analysis was performed to identify prognosis factors. P<0.05 was considered statistically significant.
Result: Among 625 IUI cycles, the clinical pregnancy rate was 8.6%. Multiple regression analysis revealed that women age (≤34 years), BMI (25 to <30 kg/m2 and 30 to <35 kg/m2), duration of infertility (≤1 years) and number of preovulatory follicle (1 follicle) significantly affects pregnancy rate during IUI treatment.
Conclusion: Women age, body mass index, duration of infertility and number of preovulatory follicle were the main influencing factors associated with clinical pregnancy rate in artificial insemination.
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