Bilateral ovarian coexistence of mature cystic teratomas and endometriomas: a unique case report

Authors

  • Natthakrit Anansitthikorn Nakhon Pathom Hospital

Keywords:

mature cystic teratoma, endometrioma, endometriotic cyst, ovary, coexistence

Abstract

        Ovarian mature cystic teratomas (MCTs) and ovarian endometriomas represent highly prevalent benign ovarian lesions in women of reproductive age.  While their individual occurrence is common, the ipsilateral coexistence of both lesions within the same ovary is rare, and their bilateral ovarian coexistence has not been found.  A 33-year-old nulligravid woman presented with a gradually enlarging pelvic mass.  Serum tumor markers, CA125 and CA19-9, were elevated. Imaging studies revealed bilateral ovarian masses consistent with MCTs, with a suspected collision tumor on the left ovary.  The patient underwent bilateral salpingo-oophorectomy.  Histopathology confirmed the presence of MCTs and endometriomas in both ovaries.  Multiple cystic follicles were also observed bilaterally.  Based on the available literature, this study describes the first documented case of bilateral ovarian coexistence of mature cystic teratomas and endometriomas, supported by detailed macroscopic and microscopic findings.

References

Comerci Jr JT, Licciardi F, Bergh PA, Gregori C, Breen JL. Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. Obstet Gynecol 1994;84(1):22–8.

Vercellini P, Viganò P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 2014;10(5):261–75.

Caruso M, Pirrelli M. A rare association between ovarian endometriosis and bilateral ovarian teratoma. Case report. Minerva Ginecol 1997;49(7-8):341–3.

Chae H, Rheu C. Endometriosis coexisting with mature cystic teratoma in the same ovary and ectopic pregnancy of left fallopian tube: a rare coexistence. Clin Case Rep 2015;3(5):315.

CHANG T-c. Endometriosis coexisting with dermoid cyst in a single ovary: A case report. Chin Med J (Engl) 2011;124(4):627–30.

Ferrario E. Association of ovarian endometriosis and dermoid cyst. Minerva Ginecol 1960;12:570–2.

van der Merwe JL, Siebert I, van Wyk AC. Rare case of perplexing ovarian endometriosis. Fertil Steril 2010;94(5):1910. e17–. e19.

Frederick J, DaCosta V, Wynter S, Tenant I, McKenzie C, McDonald Y. Endometriosis co-existing with bilateral dermoid cysts of the ovaries treated by laparoscopy. West Indian Med J 2003;52(2):179–81.

Wagner S, Deimling T, Riley K, Harkins G. Laparoscopic hysterectomy complicated by endometriosis and bilateral dermoid cysts. J Minim Invasive Gynecol 2015;22(6):S17.

Balint O SC, Pirtea L, Grigoraș D. Rare. Association Between an Endometrioma and A Mature Cystic Teratoma on the Same Ovary in A Postmenopausal Woman: A Case Report and Review of Literature. J Gynecol Women’s Health 2020;18(2):555982.

Darouichi M, Tille J-C, Dubuisson J, Stevan J. Coexistence of mature cystic teratoma and endometrioma in an ovarian cyst. Bio Med (Aligarh) 2017;9(2).

Huseyin K, Pinar K, Tolga K, Kerem S, Karatas S. Endometrioma coexisting with dermoid tumor in a single ovary presenting as atypical endometrioma: A report of two cases and literature review. CRSLS 2019;e2018.00105:1–9.

Hwang JY, Lee MH, Lee JH, Kim DH, Song SH. A case of unilateral endometriosis coexisting with struma ovarii in bilateral ovarian teratoma. J Minim Invasive Gynecol 2018;25(6):941–3.

Kuna K, Grbavac I, Vuković A, Bilić N, Kraljević Z, Butorac D. Coexistence of ruptured ectopic tubal pregnancy, dermoid and endometriotic cyst with tubo-ovarian abscess in the same adnexa: case report. Acta clinica Croatica 2015;54(1):103–5.

Prorocic M, Tasic L, Vasiljevic M, Jurisic A, Smiljkovic O, Raznatovic S, et al. Simultaneous dermoid cyst and endometriosis in the same ovary: a case report. Clin Exp Obstet Gynecol 2013;40(3):457–9.

Shams F, Ahmed S, Habib M, Anjum AS. Endometrioma coexisting with mature cystic teratoma in a single ovary: A rare presentation. J Ayub Med Coll Abbottabad 2024;36(2):447–50.

Shimura K, Matsumoto M, Sugahara T, Yamamoto T, Ogiso N, Urata Y, et al. Mature cystic teratoma coexisting with clear‐cell carcinoma in the ovary. J Obstet Gynaecol Res 2017;43(2):408–11.

Sindilar A, Socolov R, Socolov D, Terinte C, Anghelache IL. Teratoma and endometriotic ovarian cysts on ipsilateral ovary occurring after ectopic pregnancy. case presentation of a rare association. Gineco ro 2011;7(26):208–9.

Song J, Martin C. A Rare Case of a Large Composite Endometrioma–Mature Cystic Teratoma: The Importance of Surgical Treatment and Pathologic Diagnosis. Reprod Med 2024;5(4):280–7.

Taylor LH, Madhuri TK, Walker W, Morton K, Tailor A, Butler-Manuel S. Decidualisation of ovarian endometriomas in pregnancy: a management dilemma. A case report and review of the literature. Arch Gynecol Obstet 2015;291(5):961–8.

Bălăceanu LA, Grigore C, Dina I, Gurău C-D, Mihai MM, Bălăceanu-Gurău B. CA125 as a Potential Biomarker in Non-Malignant Serous Effusions: Diagnostic and Prognostic Considerations. J Clin Med 2025;14(12):4152.

Dede M, Gungor S, Yenen M, Alanbay I, Duru N, Haşimi A. CA19-9 may have clinical significance in mature cystic teratomas of the ovary. Int J Gynecol Cancer 2006;16(1):189–93.

Takahashi K, Kurioka H, Irikoma M, Ozaki T, Kanasaki H, Miyazaki K. Benign or malignant ovarian neoplasms and ovarian endometriomas. J Am Assoc Gynecol Laparosc 2001;8(2):278–84.

Matalliotaki C, Matalliotakis M, Ieromonachou P, Goulielmos GN, Zervou MI, Laliotis A, et al. Co-existence of benign gynecological tumors with endometriosis in a group of 1,000 women. Oncol Lett 2018;15(2):1529–32.

Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Goulielmos GN, Kalogiannidis I, et al. Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas. Mol Clin Oncol 2019;10(6):592–6.

Kalaitzopoulos DR, Samartzis N, Eberhard M, Grigoriadis G, Miliaras D, Papanikolaou A, et al. Co-Existence of Endometriosis with Ovarian Dermoid Cysts: A Retrospective Cohort Study. J Clin Med 2023;12(19):6308.

Matalliotakis M, Matalliotaki C, Tsakiridis I, Dagklis T, Michos G, Romanos A, et al. Co-existence of ovarian teratomas with other gynecological tumors. Cureus 2024;16(4).

Chae H. Coexistence of mature cystic teratomas and endometriosis. J Mol Clin Med 2020;3(4):91–6.

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Published

2026-06-22

How to Cite

1.
Anansitthikorn N. Bilateral ovarian coexistence of mature cystic teratomas and endometriomas: a unique case report. TUHJ [internet]. 2026 Jun. 22 [cited 2026 Jun. 27];11(2):36-44. available from: https://he02.tci-thaijo.org/index.php/TUHJ/article/view/277096

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