The multidisciplinary team approach experience in the single institute of breast cancer patients: impact on disease-free survival
Keywords:
multidisciplinary team (MDT), breast cancer, disease-free survival, retrospective analysis, ThailandAbstract
Background: Breast cancer is a significant health concern in Thailand, and the multidisciplinary team (MDT) approach is widely regarded as a strategy to improve cancer care outcomes. This study aims to evaluate the impact of MDT care on disease-free survival (DFS) in patients treated at a single institution.
Methods: This retrospective review analyzed 677 breast cancer cases treated at Thammasat Hospital from 2012 to 2021. The study compared disease-free survival (DFS) between patients managed with a multidisciplinary team (MDT) approach (n=394) and those managed without MDT involvement (n=283). Survival outcomes were assessed using Kaplan-Meier methods and Cox regression analysis.
Results: The mean disease-free survival (DFS) was 10.14 years in the MDT group, compared to 10.09 years in the non-MDT group, with no statistically significant difference observed across the 0–11.5 years follow-up period (HR: 1.061, 95% CI: 0.653–1.726, p = 0.810). However, when follow-up extended beyond 5 years, the MDT group demonstrated superior DFS compared to the non-MDT group. Significant predisposing factors influencing DFS in the MDT group included ECOG performance status, cancer staging, receipt of radiotherapy, and hormonal therapy.
Conclusion: Although MDT care does not statistically improve DFS (Disease-Free Survival), there is an observed trend suggesting a survival benefit. Furthermore, significant factors affecting DFS in the MDT group included patients' ECOG performance status, cancer staging, receipt of radiotherapy, and hormonal therapy.
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