Neuro-Ophthalmic Diseases in a Tertiary Hospital in Thailand: A Prospective Study
Keywords:
incidence, neuro-ophthalmic diseases, neuro-ophthalmic disordersAbstract
Abstract
Objective: To describe the incidence and pattern of neuro-ophthalmic diseases in the Ophthalmology
Department of Siriraj Hospital, a tertiary hospital in Thailand.
Materials and Methods: This prospective study was conducted over a one-year period. New incident
cases with confirmed diagnoses of neuro-ophthalmic diseases were enrolled. The data (comprising age,
gender, presenting symptoms, and final diagnosis) were summated and evaluated.
Results: A total of 114 patients with new incident neuro-ophthalmic diseases were seen among a total
of 9,600 new patients, giving an incidence of 1.2%. The incidence was higher among the 40–59 age group
(53.5%). The most common disorders were non-arteritic anterior ischemic optic neuropathy (NAION; 7%),
optic neuritis (7%), oculomotor palsy (6.1%), pituitary tumor (6.1%), and abducens palsy (5.3%). The most
commonly presented symptoms were decreased vision (48.2%) and double vision (21.1%). Twenty-two
patients (19.3%) were blind in the affected eye.
Conclusions: Optic neuropathy and ocular motor palsies are the leading neuro-ophthalmic disorders.
Although the overall incidence of neuro-ophthalmic diseases is low, diseases are often related to blindness
or life-threatening conditions.
References
Lim SA, Wong WL, Fu E, et al. The incidence of neuroophthalmic diseases in Singapore: a prospective study in public hospitals. Ophthalmic Epidemiol.
;16(2):65-73.
Omoti AE, Waziri-Erameh MJ. Pattern of neuroophthalmic disorders in a tertiary eye centre in Nigeria. Niger J Clin Pract. 2007;10(2):147-51.
Masson-Le Guen E, Cochard-Marianowski C, Macarez R, Charlin JF, et al. [Neuro-ophthalmological assessments in the Ophthalmology Department at University Medical Center, Brest: retrospective study of 269 patients (January 2004–October 2009)]. J Fr Ophtalmol. 2012;35(10):768-75.
Burrow GN, Wortzman G, Rewcastle NB, et al. Microadenomas of the pituitary and abnormal sellar tomograms in an unselected autopsy series. N Engl J Med. 1981;304(3):156–8.
Toosy AT, Mason DF, Miller DH. Optic neuritis. The Lancet Neurology. 2014;13(1):83-99.
Wakakura M, Ishikawa S, Oono S, et al. [Incidence of acute idiopathic optic neuritis and its therapy in Japan. Optic Neuritis Treatment Trial Multicenter
Cooperative Research Group (ONMRG)]. Nippon Ganka Gakkai Zasshi. 1995;99(1):93-7.
Jin YP, de Pedro-Cuesta J, Soderstrom M, et al. Incidence of optic neuritis in Stockholm, Sweden, 1990–1995: II. Time and space patterns. Archives of neurology. 1999;56(8):975-80.
Bojic L, Ivanisevic M, Sinicic A, et al. The incidence of optic neuritis in Split-Dalmatia county, Croatia. Coll Antropol. 2004;28(1):343-7.
Rosati G. The prevalence of multiple sclerosis in the world: an update. Neurol Sci. 2001;22(2):117-39.
Miller NR, Arnold AC. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy.
Eye (Lond). 2015;29(1):65-79.
Hattenhauer MG, Leavitt JA, Hodge DO, et al. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1997;123(1):103-7.
Johnson LN, Arnold AC. Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy. Population-based study in the state of Missouri
and Los Angeles County, California. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 1994;14(1):38-44.
Guyer DR, Miller NR, Auer CL, et al. The risk of cerebrovascular and cardiovascular disease inpatients with anterior ischemic optic neuropathy. Arch Ophthalmol. 1985;103(8):1136-42.
Lee JY, Park KA, Oh SY. Prevalence and incidence of non-arteritic anterior ischaemic optic neuropathy in South Korea: a nationwide population-based study.
Br J Ophthalmol. 2017.
Downloads
Published
Issue
Section
License
The Thai Journal of Ophthalmology (TJO) is a peer-reviewed, scientific journal published biannually for the Royal College of Ophthalmologists of Thailand. The objectives of the journal is to provide up to date scientific knowledge in the field of ophthalmology, provide ophthalmologists with continuing education, promote cooperation, and sharing of opinion among readers.
The copyright of the published article belongs to the Thai Journal of Ophthalmology. However the content, ideas and the opinions in the article are from the author(s). The editorial board does not have to agree with the authors’ ideas and opinions.
The authors or readers may contact the editorial board via email at admin@rcopt.org.
