Central Serous Chorioretinopathy Coincident with Suprasellar Meningioma: A Case Report
Abstract
A 41-year-old woman with systemic lupus erythematosus (SLE) presented with blurred vision in her right eye for 3 months. A few weeks later, she developed progressive painless visual loss with an involved central area of vision in her right eye. Ophthalmological examination and OCT macula scan revealed serous subretinal fluid in the right macular region. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were subsequently
performed a few weeks later. The patient underwent focal laser photocoagulation at an extrafoveal leakage site in the right eye, guided by FFA and ICGA findings. However, her visual function continued to deteriorate. Visual field testing demonstrated a significant bitemporal hemianopic defect. Contrast-enhanced magnetic resonance imaging (MRI) of the brain and orbit revealed a suprasellar mass compressing the optic chiasm, consistent with a meningioma.
This case report describes an SLE patient receiving systemic corticosteroids who developed central serous chorioretinopathy (CSCR) and was subsequently found to have a suprasellar meningioma compressing the optic chiasm.
The concurrence of CSCR and meningioma in this patient is best interpreted as a coincidental coexistence, and no causal association is implied. Although neuroimaging is not routinely indicated for typical CSCR, it should be considered when
visual function is disproportionately poor, when symptoms progress, when perimetry suggests a chiasmal pattern, or when visual impairment persists despite apparent anatomical resolution of subretinal fluid.
References
Kaye R, Chandra S, Sheth J, Boon CJF, Sivaprasad S, Lotery A. Central serous chorioretinopathy: an update on risk factors, pathophysiology and imaging modalities. Prog Retin Eye Res. 2020;79:100865. doi:10.1016/j.preteyeres.2020.100865
Spaide RF, Cheung CMG, Matsumoto H, et al. Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders. Prog Retin Eye Res. 2022;86:100973. doi:10.1016/j.preteyeres.2021.100973
Warrow DJ, Hoang QV, Freund KB. Pachychoroid pigment epitheliopathy. Retina. 2013;33(8):1659-1672. doi:10.1097/IAE.0b013e3182953df4
Spaide RF, Campeas L, Haas A, et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology.1996;103(12):2070-2079.
Kitzmann AS, Pulido JS, Diehl NN, Hodge DO, Burke JP. The incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980–2002. Ophthalmology. 2008;115(1):169-173. doi:10.1016/j.ophtha.2007.02.032
Liew G, Quin G, Gillies M, Fraser-Bell S. Central serous chorioretinopathy: a review of epidemiology and pathophysiology. Clin Experiment Ophthalmol. 2013;41(2):201-214. doi:10.1111/j.1442-9071.2012.02848.x
Carvalho-Recchia CA, Yannuzzi LA, Negrão S, et al. Corticosteroids and central serous chorioretinopathy. Ophthalmology. 2002;109(10):1834-1837.
Nicholson B, Noble J, Forooghian F, Meyerle C. Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol. 2013;58(2):103-126. doi:10.1016/j.survophthal.2012.07.004
Tsai DC, Chen SJ, Huang CC, et al. Risk of central serous chorioretinopathy in adults prescribed oral corticosteroids: a population-based study in Taiwan. Retina. 2014;34(9):1867-1874. doi:10.1097/IAE.0000000000000159
Liu B, Deng T, Zhang J. Risk factors for central serous chorioretinopathy: a systematic review and meta-analysis. Retina. 2016;36(1):9-19. doi:10.1097/IAE.0000000000000837
Araki T, Ishikawa H, Iwahashi C, et al. Central serous chorioretinopathy with and without steroids: a multicenter survey. PLoS One. 2019;14(2):e0213110. doi:10.1371/journal.pone.0213110
Tittl MK, Spaide RF, Wong D, et al. Systemic findings associated with central serous chorioretinopathy. Am J Ophthalmol. 1999;128(1):63-68. doi:10.1016/S0002-9394(99)00075-6
Haimovici R, Koh S, Gagnon DR, Lehrfeld T, Wellik S. Risk factors for central serous chorioretinopathy: a case-control study. Ophthalmology. 2004;111(2):244-249.
Ge G, Zhang Y, Zhang Y, Xu Z, Zhang M. Corticosteroid usage and central serous chorioretinopathy: a meta-analysis. Graefes Arch Clin Exp Ophthalmol. 2020;258(1):71-77. doi:10.1007/s00417-019-04486-w
Nudleman E, Witmer MT, Kiss S, Williams GA, Wolfe JD. Central serous chorioretinopathy in patients receiving exogenous testosterone therapy. Retina. 2014;34(10):2128-2132. doi:10.1097/IAE.0000000000000198
van Dijk EH, Nijhoff MF, de Jong EK, et al. Central serous chorioretinopathy in primary hyperaldosteronism. Graefes Arch Clin Exp Ophthalmol. 2016;254(10):2033-2042.
Çiloğlu E, Unal F, Doğan NC. The relationship between central serous chorioretinopathy, choroidal thickness, and serum hormone levels. Graefes Arch Clin Exp Ophthalmol. 2018;256(6):1111-1116.
Jiang MS, Xu XL, Yang T, Li F, Zhang XD. Comparison of choroidal thickness in preeclamptic, healthy pregnant, and nonpregnant women: a systematic review and meta-analysis. Ophthalmic Res. 2019;62(1):1-10. doi:10.1159/000499916
Karadağ MF. A new potential risk factor for central serous chorioretinopathy: blood pressure variability. Eye.2021;35(8):2190-2195. doi:10.1038/s41433-020-01222-1
van Dijk EHC, Soonawala D, Rooth V, et al. Spectrum of retinal abnormalities in renal transplant patients using chronic low-dose steroids. Graefes Arch Clin Exp Ophthalmol. 2017;255(12):2443-2449. doi:10.1007/s00417-017-3823-6
Fawzi AA, Holland GN, Kreiger AE, Heckenlively JR, Arroyo JG, Cunningham ET Jr. Central serous chorioretinopathy after solid organ transplantation. Ophthalmology. 2006;113(5):805-813.e5.
Yannuzzi LA. Type-A behavior and central serous chorioretinopathy. Trans Am Ophthalmol Soc. 1986;84:799-845.
Miki A, Kondo N, Yanagisawa S, Bessho H, Honda S, Negi A. Common variants in the complement factor H gene confer genetic susceptibility to central serous chorioretinopathy. Ophthalmology. 2014;121(5):1067-1072.
Vance SK, Imamura Y, Freund KB. The effects of sildenafil citrate on choroidal thickness as determined by enhanced depth imaging optical coherence tomography. Retina. 2011;31(2):332-335.
Pan CK, Vail D, Bhattacharya J, Cao M, Mruthyunjaya P. The effect of obstructive sleep apnea on absolute risk of central serous chorioretinopathy. Am J Ophthalmol. 2020;218:148-155.
Ji Y, Li M, Zhang X, Peng Y, Wen F. Poor sleep quality is a risk factor for central serous chorioretinopathy. J Ophthalmol. 2018;2018:9450297. doi:10.1155/2018/9450297
Tien PT, Lai CY, Lin CJ, et al. Increased risk of central serous chorioretinopathy among patients with nonorganic sleep disturbance. J Ophthalmol. 2020;2020:1712503. doi:10.1155/2020/1712503
Ersöz MG, Arf S, Hocaoglu M, Sayman Muslubas I, Karacorlu M. Patient characteristics and risk factors for central serous chorioretinopathy: an analysis of 811 patients. Br J Ophthalmol. 2019;103(6):725-729.
Daruich A, Matet A, Dirani A, et al. Central serous chorioretinopathy: recent findings and new physiopathologic hypotheses. Prog Retin Eye Res. 2015;48:82-118. doi:10.1016/j.preteyeres.2015.05.003
Sato H, Takeda A, Tanaka Y, Otsuka N, Koike T. Atypical severe central serous chorioretinopathy in a patient with systemic lupus erythematosus improved with rapid reduction of glucocorticoid. Mod Rheumatol. 2013;23(1):172-174.
Castellino G, Govoni M, Padovan M, Rizzo N, Bosi S, Trotta F. Meningioma and systemic lupus erythematosus: a matter of pure coincidence? Lupus. 2009;18(7):650-654.
Abdulqader SB, Al-Taie AH, Al-Mahdawi AM, Al-Azzawi MA, Al-Attar ZM, Al-Obaidi SM, et al. High-grade spheno-orbital meningioma in patients with systemic lupus erythematosus: two case reports and literature review. Surg Neurol Int. 2020;11:367.
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