Diagnostic Accuracy of Urine Cytology for Urothelial Carcinoma Screening: Retrospective Study in Ramathibodi Hospital
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Abstract
OBJECTIVE:
This study aimed to validate the accuracy of urine cytology and histopathology in all urine specimens examined in Ramathibodi hospital from 2013 to 2016.
MATERIAL AND METHOD:
All urine cytological specimens from all groups of patients submitted for urine cytology with accompanying histological tissue samples collected concurrently or within 1 year after cytological diagnosis and examined from 2013 to 2016 were reviewed and correlated.
RESULTS:
Two hundred and eleven samples were included. Cytological diagnostic results were 47.9%, 27.5% and 24.6% of negative, atypia/low-grade urothelial neoplasm and suspicious for malignancy/malignancy categories, respectively. Histopathological diagnoses comprised 48.3%, 21.8% and 29.9% negative/unremarkable, benign neoplasm/ atypia/low-grade papillary urothelial carcinoma and high-grade papillary urothelial carcinoma/carcinoma in situ/infiltrating urothelial carcinoma categories, subsequently. The sensitivity and specificity of high-grade urothelial carcinoma were 55.6% and 88.5%. Positive predictive value and negative predictive value were 67.3% and 82.4%.
CONCLUSION:
Urine cytology has rather less sensitivity but high specificity for detection of urothelial carcinoma. Nowadays, it plays an important role to facilitate the physician for planning the management. However, integration of clinical information, urine cytological diagnosis and histopathological diagnosis is necessary for the most accurate diagnosis of urothelial carcinoma.
Article Details
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