The The Accuracy of Serum Prostate-Specific Antigen (PSA) Level of 4-10 ng/ml with Age and Digital Rectal Examination in Prostate Cancer Prediction

Authors

  • Piyathida Kalayanon Medical Education Center, Uttaradit Hospital
  • Yanathorn Keawkaew Medical Education Center, Uttaradit Hospital
  • Natthaphat Haekawee Medical Education Center, Uttaradit Hospital

DOI:

https://doi.org/10.1016/hscr.v37i2.259633

Keywords:

Accuracy, Serum Prostate-specific antigen (PSA), Prostate cancer

Abstract

ABSTRACT
Objective: To study the accuracy of serum PSA level 4-10 with age and digital rectal examination in prostate cancer prediction.
Methods: From January 1st, 2017 to June 30th, 2022. The Diagnostic prediction research using a retrospective case-control study, data was collected from ICD-10 medical records from patients who were suspected to have prostate cancer and had pathologic biopsy results were studied at Uttaradit hospital. All data were analyzed by descriptive and analytic statistics.
Results: Prostate cancer prediction accuracy with serum PSA 4-10 ng/ml have sensitivity 77.5%, specificity 69.2%, positive predictive value 88.6%, negative predictive value 50.0% and AUROC 0.81 (95% CI 0.71-0.91, p=0.011). When serum PSA 4-10 ng/ml was considered in combination with age and rectal examination, sensitivity 88.9%, specificity 66.7%, positive predictive value 88.9%, Negative predictive value 66.7% increased predictive value. The occurrence of prostate cancer was AUROC 0.93 (95% CI 0.84-1.00, p<0.001)

Conclusion: In this study, the accuracy in prostate cancer prediction, Serum PSA alone is not appropriate for the diagnosis of prostate cancer. If serum PSA 4-10 ng/ml was considered with age and digital rectal examination, it should be more accurate in predicting the incidence of prostate cancer
Keywords: Accuracy, Serum Prostate-specific antigen (PSA), Rectal examination, Prostate cancer

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Published

2022-12-30

How to Cite

1.
Kalayanon P, Keawkaew Y, Haekawee N. The The Accuracy of Serum Prostate-Specific Antigen (PSA) Level of 4-10 ng/ml with Age and Digital Rectal Examination in Prostate Cancer Prediction. HSCR [Internet]. 2022 Dec. 30 [cited 2024 Oct. 10];37(2):25-36. Available from: https://he02.tci-thaijo.org/index.php/hscr/article/view/259633

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