Encapsulating Peritoneal Sclerosis (EPS)
Keywords:
Encapsulating Peritoneal Sclerosis (EPS), Peritoneal dialysis, Duration of the peritoneal dialysis, bio-incompatibility solutionAbstract
Encapsulating Peritoneal Sclerosis (EPS) is a rare disease in peritoneal dialysis patients. However, the mortality rate of this condition is more than 50% in the 1-year follow-up period. The pathogenesis of the disease is unclear. The major risk factors are the duration of the peritoneal dialysis, history of peritonitis and bio-incompatibility PD solution. The pathology of EPS is the disappearance of mesothelial cells with fibrin adhesion that attaches to the intestinal tract and visceral organs. There are no definite definitions of EPS. Diagnosis require two components, which are intestinal obstruction or ileus and physical changes of the peritoneal from radiographic imaging. The best predictor of EPS is duration of PD treatment, an increase in peritoneal solute transport rate (PSTR) and an increase in creatinine D / P ratio. However, any biomarker can’t be used to predict or screen for EPS. Current treatment depends on the stage of the disease. It is recommended that all EPS patients should stop peritoneal dialysis. Steroids or tamoxifen may be benefit for EPS when combined nutritional therapy. Finally, surgical treatment by a specialist surgeon is recommended if the symptom does not improve.
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