Encapsulating Peritoneal Sclerosis (EPS)

Authors

  • Pratya Pumuthaivirat Nephrologist, Kidney Centre Internal Medicine Department, Chulabhorn hospital HRH Princess Chulabhorn College of Medical Science Chulabhorn Royal Academy
  • Thatsaphan Srithongkul Division of Nephrology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

Encapsulating Peritoneal Sclerosis (EPS), Peritoneal dialysis, Duration of the peritoneal dialysis, bio-incompatibility solution

Abstract

Encapsulating Peritoneal Sclerosis (EPS) is a rare disease in peritoneal dialysis patients. However, the mortality rate of this condition is more than 50% in the 1-year follow-up period. The pathogenesis of the disease is unclear. The major risk factors are the duration of the peritoneal dialysis, history of peritonitis and bio-incompatibility PD solution. The pathology of EPS is the disappearance of mesothelial cells with fibrin adhesion that attaches to the intestinal tract and visceral organs. There are no definite definitions of EPS. Diagnosis require two components, which are intestinal obstruction or ileus and physical changes of the peritoneal from radiographic imaging. The best predictor of EPS is duration of PD treatment, an increase in peritoneal solute transport rate (PSTR) and an increase in creatinine D / P ratio. However, any biomarker can’t be used to predict or screen for EPS. Current treatment depends on the stage of the disease. It is recommended that all EPS patients should stop peritoneal dialysis. Steroids or tamoxifen may be benefit for EPS when combined nutritional therapy. Finally, surgical treatment by a specialist surgeon is recommended if the symptom does not improve.

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References

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EPS

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Published

2020-04-30

How to Cite

1.
Pumuthaivirat P, Srithongkul T. Encapsulating Peritoneal Sclerosis (EPS). J Chulabhorn Royal Acad [Internet]. 2020 Apr. 30 [cited 2024 Nov. 22];2(2):9-24. Available from: https://he02.tci-thaijo.org/index.php/jcra/article/view/232754

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Academic Articles