Radiation Dose Reduction in Whole Brain Perfusion Computed Tomography Using 320-detector Computed Tomography
Keywords:
320-detector CT, radiation dose, whole- brain perfusion CTAbstract
Background: Radiation dose reduction in whole-brain perfusion computed tomography (CT) can be performed using various methods. We used a protocol with approximately 30% tube current of the original control protocol (Protocol 1) and a reduced total scan volume protocol (Protocol 2).
Methods: We conducted a retrospective consecutively analysis of whole-brain perfusion CT in 15 adult patients using the control protocol. A further 10 patients underwent protocol 1, and another 10 patients underwent protocol 2. We performed quantitative analyses and assessed the diagnostic image quality of the parametric map images. The percentage of radiation dose reductions was calculated.
Results: The gray and white matter signal intensities were higher in the cerebral blood volume and flow maps of protocol 1 than protocol 2, whereas this opposite results pattern was reversed for the time to peak and mean transit time maps. The signal-to-noise ratios of the gray and white matter for protocol 1 was inferior to that of protocol 2 for all perfusion parameters. No significant quantitative differences in parametric maps were found between the control protocol and protocol 1 or 2. The differences in the radiation dose reduction between protocols 1 and 2 and the control protocol were 33.23% and 19.95%, respectively. The effective dose of protocol 1 was reduced to approximately half that of the control protocol.
Conclusions: Radiation dose was significantly lower in protocol 1 than in the control protocol while providing comparable parametric image quality in regard to both the gray and white matter signal and signal-to-noise ratios of the parametric maps.
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