Original Research Article: Preterm labor in pregnant women who receiving uterine contractile inhibitors to delay preterm labor: A factor analysis and event-free period

Abstract

Premature birth is related to many factors. Use drugs to inhibit uterine contraction to slow the premature delivery of high-risk pregnant woman, it is an issue that still needs further study. This study aimed to determine the risk factors associated with preterm birth and the event free-period of preterm birth. In 2022, a study was conducted in Kaeng Kro Hospital in Chaiyaphum province on pregnant women who receive uterine contraction inhibition drugs and gave birth, 321 cases. There are 8 input factors in the analysis of risk factors related to premature delivery. When analyzing the risk factors related to the free period of premature delivery, there are four input factors. The results showed that the rate of preterm birth in sample group was 19% (95% CI: 15.1, 23.7). There is only one factor that affects pregnant women’s acceptance of intrauterine devices to delay premature delivery, it is to take drugs that inhibit uterine contraction to slow premature delivery. The numbers of days taking every day is increasing, it can reduce the premature birth rate by about 17% (Odds ratio = 0.83; 95% CI: 0.75, 0.92). Though the analysis of the event-free stage, the size of the cervical opening before delivery (Hazard ratio = 39.63; 95% CI: 15.71, 99.98) and the complications during pregnancy (Hazard ratio = 3.42; 95% CI: 1.41, 8.31) are found. Taking anti-uterine contraction drugs is effective in reducing or delaying premature delivery, but still not perfect. The pregnancy indication is a complication, it is necessary to develop appropriate pregnancy care guidelines in term monitoring, service and innovation.