Incidence and Associated Factors of Intracerebral Hemorrhage Complication after Intravenous Recombinant Tissue Plasminogen Activator (rt-PA) in Kalasin Hospital, Fiscal year 2021-2023
Keywords:
stroke, intracranial hemorrhage, thrombolytic therapy, risk factors, KalasinAbstract
This retrospective cohort study investigated the incidence and factors associated with intracerebral hemorrhage complications after intravenous Recombinant tissue plasminogen activator (rt-PA) at Kalasin Hospital during the fiscal years 2021 to 2023.The study described patient characteristics, analyzed the correlation coefficients of the studied factors, and tested differences between groups with and without intracranial hemorrhage following thrombolytic therapy using the chi-square or Fisher's exact test,
as well as the Student's t-test or Wilcoxon Rank Sum test. The study identified factors influencing the occurrence of this condition through generalized linear models (GLMs). The findings revealed that the incidence of intracranial hemorrhage after thrombolytic therapy in patients with stroke was 12.43% (95% CI: 8.49, 17.38). The study found that significant risk factors included elevated WBC count (ARR= 1.01, 95% CI: 1.01, 1.01), INR (ARR= 10.50, 95% CI: 2.07, 53.34), and higher NIHSS scores (ARR= 1.07, 95% CI: 1.01, 1.14).
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