Factors Associated with Peripheral Phlebitis in Neonates Receiving Intravenous Fluids in the Pediatric Intensive Care Unit, Mukdahan Hospital
Keywords:
Peripheral Phlebitis, Neonates, FactorAbstract
This retrospective matched case-control study aimed to investigate factors associated with peripheral phlebitis in neonates receiving intravenous fluids in the pediatric intensive unit at Mukdahan hospital. A total of 120 neonates were included (case 40, control 80), matched by gestational age. Data were collected from medical record between October 1, 2024 to September 30, 2025. Research instrument included data extraction form and phlebitis assessment records, with Index of items-objective congruence > 0.50, Content validity index of 0.89 and Inter-rater reliability (Cohen’s Kappa) of 0.89. Data were analyzed using descriptive statistics, bivariate analysis with conditional logistic regression and multivariable logistic regression with Firth’s penalized logistic regression. The results showed that DN/5 solution (Adj.OR=136.29, 95% CI: 20.70–897.16, p<0.001) and changing IV site after 72 hours (Adj.OR=18.41, 95% CI: 1.03–327.77, p=0.047) were statistically significantly associated with peripheral phlebitis in neonates receiving intravenous fluids. while other variables were not statistically significant. This finding can be to monitor the administration of hypertonic solutions and be used to develop model of clinical practice guideline and nursing for prevention and caring of peripheral phlebitis in neonates.
References
Mandal A, Raghu K, Sinha R. Study on incidence of phlebitis following the use of peripheral intravenous catheter and evaluation of related factors. J Family Med Prim Care. 2019;8(9):2828-2832.
Yasuda H, Matsuo K, Kawahara Y. Risk factors for peripheral intravascular catheter-related phlebitis in children. Pediatr Crit Care Med. 2022;23(4):e198-e205.
Suliman M. The incidence of peripheral intravenous catheter phlebitis and risk factors among pediatric patients: A prospective observational study. J Pediatr Nurs. 2020;55:e54-e60.
Guanche-Sicilia A, Fernandez-Gutierrez T, Moya-Suarez AB, Lorenzo-López C. Prevention and treatment of phlebitis secondary to the use of peripheral intravenous catheters: A systematic review. J Vasc Access. 2021;22(3):344-353.
Varolan V. Phlebitis in pediatric patients: prevention and care. Thai J Cardio-Thorac Nurs. 2017;28(1):16-28.
Srisa-ard B. Introduction to research. Bangkok: Suwiriyasarn; 2010.
Fleiss JL, Levin B, Paik MC. Statistical methods for rates and proportions. 3rd ed. Hoboken: Wiley; 2013.
Kelsey JL, Whittemore AS, Evans AS, Thompson WD. Methods in observational epidemiology. 2nd ed. New York: Oxford University Press; 1996.
Infusion Nurses Society. Infusion therapy standards of practice. J Infus Nurs. 2016;39(1S):S1-S159.
Seid K, Lakew G, Yirsaw AN, et al. Incidence of peripheral intravenous cannula induced phlebitis and its determinants among admitted patients in Ethiopia: systematic review and meta-analysis. Discov Med. 2024;1:89.
Tannukit P, Sukeenit S, Chaopothong J. A prevalence survey of phlebitis by intravenous therapy in Thailand. J Charoenkrung Pracharaks Hosp. 2024;20(2):7-19.
Kokaew P. The effectiveness of preventive practices phlebitis from high alert drugs, Intensive Care Unit 2, Lamphun Hospital. J Public Health Health Educ. 2024;4(1):e266990.
Ertaş Akyüz G, Turan N. Association between peripheral intravenous catheters and clinical characteristics in the development of phlebitis. J Vasc Access. 2025;26(2):540-546.
Trairatnopas V, Kongton N. Prevention and Management of Phlebitis from Intravenous Therapy. J Nurs Sci Christian Univ Thail. 2025;12(2):152-165.
Igarashi A, Okuno T, Shimizu T, Ohta G, Ohshima Y. Mechanical stimulation is a risk factor for phlebitis associated with peripherally inserted central venous catheter in neonates. Pediatr Int. 2021;63(5):561.
Simões AMN, Vendramim P, Pedreira MLG. Risk factors for peripheral intravenous catheter-related phlebitis in adult patients. Rev Esc Enferm USP. 2022;56:e20210398.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Khonkaen Public Health Provincial Office
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของสำนักงานสาธารณสุขจังหวัดขอนแก่น กระทรวงสาธารณสุข
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับสำนักงานสาธารณสุขจังหวัดขอนแก่น และบุคลากรท่านอื่นๆในสำนักงานฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
