Original Research Article: Comparison of Covid-19 Patient at Risk Group (608) who Received the Vaccine and not Vaccinated in Kaeng Khro Hospital.

Abstract

Vaccination campaign against COVID-19 in high-risk group 608 is also necessary. At the same time, it is also important to monitor the safety of the target audience. This study aims to compare the adverse reactions caused by vaccination or non-vaccination with the target population infected with COVID-19. A cross-sectional study was conducted 1,086 of 608 high-risk groups with COVID-19 and was admitted to Kaeng Khro hospital between April 2021 to April 2022.

The resulted showed that more than half of the sample were elderly (68.9%), followed by diabetes (14.9%). And received 84.4%, 79.7%, 41.8% and 0.5% of the 1^st, 2^nd, 3^rd and 4^th dose vaccines, respectively. It consists of the three types of vaccines, Corona Vac, AZD1222 and tozinameran (BNT162b2), in descending proportions. There were 12 adverse reactions in COVID-19 patient. From the Multiple logistic regression statistical test, 6 adverse reactions associated with not being vaccinate were fever, cough, sore throat, fatigue, dyspnea and chest pain and one symptom associated with vaccination was conjunctivitis (Odds ratio = 3.59; 95% CI: 1.93, 6.69). In addition, those infected with COVID-19 who were not vaccinated had 38.77 times the risk of lung infection or pneumonia (95% CI: 25.12, 59.84). Furthermore, the adverse reactions in patients with COVID-19 related to vaccinations times, type of vaccine administered has similar effect.

 Research showed the advantage of COVID-19 vaccination is that it can prevent adverse reactions in most patients, Although the vaccinated people still have some other adverse reactions, only a few of them are mild. Moreover, this research continuous to support the policy of the Ministry of Health to carry out vaccination campaign among high-risk group.