Factors Predicting Sarcopenia in Thai Older Adults at a Super Tertiary Care Hospital

Main Article Content

Suphawadee Krangphanich
Virapun Wirojratana
Prangthip Chayaput
Varalak Srinonprasert

Abstract

Purpose: To determine predictability of nutrition status, cognitive impairment, depression, and polypharmacy on sarcopenia in Thai older adults.


Design: Predictive correlational research.


Methods: The sample consisted of 220 older adults aged 60 years and over, both male and female, who had received geriatric medicine services at a geriatric clinic in a super tertiary care hospital in Bangkok. Data were collected using the personal and clinical data record form, the Mini Assessment Nutrition Short Form, the Thai mental state examination, and the Thai Geriatric Depression Scale. The Asian Working Group for Sarcopenia criteria were implemented to measure muscle mass, physical performance, and muscle strength. Descriptive statistics and binary logistic regression were employed to analyze data.


Main findings: Average age of the sample was 76.49 years (SD = 7.89) with 72.7% of females and 30.5% of sarcopenia. Nutritional status, cognitive impairment, depression, and polypharmacy could account for 38.3% of the variance explained in sarcopenia (Nagelkerke R2 = .38). Older adults with abnormal nutritional status (at risk or malnourished), cognitive impairment, and recent polypharmacy (use of more than five medications) were respectively 5.32, 3.26, and 7.29 times more likely to develop sarcopenia compared to their counterparts. Depression was unable to predict sarcopenia.


Conclusion and recommendations: At risk of malnutrition, cognitive impairment, polypharmacy could significantly increase older adults’ chance of having sarcopenia. The research findings can be utilized as clinical data to assess geriatric syndrome in older adults and to plan for the prevention of sarcopenia among older adults who are at risk of malnutrition, having cognitive impairment, and using more than five medications (polypharmacy).

Article Details

How to Cite
Krangphanich, S., Wirojratana, V. ., Chayaput, P., & Srinonprasert, V. (2025). Factors Predicting Sarcopenia in Thai Older Adults at a Super Tertiary Care Hospital. Nursing Science Journal of Thailand, 43(4), 377–388. retrieved from https://he02.tci-thaijo.org/index.php/ns/article/view/274987
Section
Research Articles

References

Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2022;13(1):86-99. doi: 10.1002/jcsm.12783.

Therakomen V, Petchlorlian A, Lakananurak N. Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study. Sci Rep. 2020;10(1):19551. doi: 10.1038/s41598-020-75250-y.

Chaithongkrua P, Temcharoen P, Chandrasiri V, Soontornchai S. The prevalence and related factors of sarcopenia among the elderly in Sattahip District, Chonburi Province. Journal of The Department of Medical Service. 2021;46(2):103-10. (in Thai).

Thai Health Promotion Foundation. Health dimension of the aging society in Thailand [Internet]. Nakhon Prathom: ThaiHealthReport.com; 2025 [cited 2025 May 30]. Available from: https://www.thaihealthreport.com/th/articles_detail.php?id=222. (in Thai).

Xu J, Wan CS, Ktoris K, Reijnierse EM, Maier AB. Sarcopenia is associated with mortality in adults: a systematic review and meta-analysis. Gerontology. 2022;68(4):361-76. doi: 10.1159/000517099.

Tsekoura M, Billis E, Matzaroglou C, Tsepis E, Gliatis J. Association between chronic pain and sarcopenia in Greek community-dwelling older adults: a cross-sectional study. Healthcare (Basel). 2024;12(13):1303. doi: 10.3390/healthcare12131303.

Wang B, Wei Y, Shao L, Li M, Zhang X, Li W, et al. Association of dietary patterns and sarcopenia in the elderly population: a cross-sectional study. Front Aging. 2023;4:1239945. doi: 10.3389/fragi.2023.1239945.

Fazzini B, Märkl T, Costas C, Blobner M, Schaller SJ, Prowle J, et al. The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis. Crit Care. 2023;27(1):2. doi: 10.1186/s13054-022-04253-0.

Pourhassan M, Rommersbach N, Lueg G, Klimek C, Schnatmann M, Liermann D, et al. The impact of malnutrition on acute muscle wasting in frail older hospitalized patients. Nutrients. 2020;12(5):1387. doi: 10.3390/nu12051387.

American Psychological Association. APA clinical practice guideline for the treatment of depression across three age cohorts [Internet]. Washington, D.C.: APA; 2019 [cited 2024 Aug 30] Available from: https://www.apa.org/depression-guideline.

Gariballa S, Alessa A. Associations between low muscle mass, blood-borne nutritional status and mental health in older patients. BMC Nutr. 2020;6:6. doi: 10.1186/s40795-019-0330-7.

Marques A, Gomez-Baya D, Peralta M, Frasquilho D, Santos T, Martins J, et al. The effect of muscular strength on depression symptoms in adults: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020;17(16):5674. doi: 10.3390/ijerph17165674.

Arosio B, Calvani R, Ferri E, Coelho-Junior HJ, Carandina A, Campanelli F, et al. Sarcopenia and cognitive decline in older adults: targeting the muscle-brain axis. Nutrients. 2023;15(8):1853. doi: 10.3390/nu15081853.

Pana A, Sourtzi P, Kalokairinou A, Velonaki VS. Sarcopenia and polypharmacy among older adults: a scoping review of the literature. Arch Gerontol Geriatr. 2022;98:104520. doi: 10.1016/j.archger.2021.104520.

Jeeyavudeen MS, Pappachan JM, Arunagirinathan G. Statin-related muscle toxicity: an evidence-based review. touchREV Endocrinol. 2022;18(2):89-95. doi: 10.17925/EE.2022.18.2.89.

Roy C, Whetsell MV, Frederickson K. The Roy adaptation model and research. Nurs Sci Q. 2009;22(3):209-11. doi: 10.1177/0894318409338692.

Demidenko E. Sample size determination for logistic regression revisited. Stat Med. 2007;26(18):3385-97. doi: 10.1002/sim.2771.

Liu X, Xia X, Hu F, Hou L, Jia S, Liu Y, et al. Nutrition status mediates the association between cognitive decline and sarcopenia. Aging (Albany NY). 2021;13(6):8599-610. doi: 10.18632/aging.202672.

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16-31. doi: 10.1093/ageing/afy169.

Banchong A, Jaroonrak J, Ekkantong P, Thamachotiphong S. Masticatory ability and nutritional status among the elderly. Journal of Health Promotion and Environmental Health. 2005;28(2):77-90. (in Thai).

Train the Brain Forum Committee. Thai geriatric depression scale-TGDS. Siriraj Hospital Gazette. 1994;46(1):1-9. (in Thai).

Train the Brain Forum Committee. Thai Mental State Examination (TMSE). Siriraj Hospital Gazette. 1993;45(6):359-74. (in Thai).

Pan L, Xie W, Fu X, Lu W, Jin H, Lai J, et al. Inflammation and sarcopenia: a focus on circulating inflammatory cytokines. Exp Gerontol. 2021;154:111544. doi: 10.1016/j.exger.2021.111544.